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    METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE
    3.
    发明申请
    METHOD FOR ENHANCING IMMUNE RESPONSE WITH PEPTIDE 有权
    用于增强与肽的免疫应答的方法

    公开(公告)号：US20120107334A1

    公开(公告)日：2012-05-03

    申请号：US13220452

    申请日：2011-08-29

    申请人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    发明人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    IPC分类号： A61K39/00 ,  A61P25/28 ,  A61P37/04 ,  C07K14/435

    CPC分类号： A61K39/0007 ,  A61K31/711 ,  C07K14/4711

    摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.

    摘要翻译： 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默氏病的药物，其包括淀粉样蛋白 诱导增强的免疫应答的肽。 淀粉样蛋白 肽或其部分，其中加入或插入半胱氨酸，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含淀粉样蛋白 肽或其部分诱导增强的免疫应答。 可以具有相同效果的DNA疫苗，其包含编码淀粉样肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

    MODIFIED AMYLOID BETA PEPTIDE
    4.
    发明申请
    MODIFIED AMYLOID BETA PEPTIDE 有权
    改性AMYLOID BETA肽

    公开(公告)号：US20110268756A1

    公开(公告)日：2011-11-03

    申请号：US13124260

    申请日：2009-10-16

    申请人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    发明人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    IPC分类号： A61K39/00 ,  A61P37/04 ,  A61P25/28 ,  C07K14/47 ,  C07K7/08

    CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/53

    摘要： An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis and treatment of Alzheimer disease. An amyloid β peptide or a portion thereof with addition or insertion of cysteine or a cysteine analogue, and a method for enhancing immune response to amyloid β using said peptide, a medicament for prophylaxis and treatment of Alzheimer disease using said amyloid β peptide that induces an enhanced immune response, and a DNA vaccine comprising a gene coding for an amyloid β peptide or a sequence derived from an amyloid β peptide with addition or insertion of cysteine or a cysteine analogue, as expected to be similarly efficacious.

    摘要翻译： 本发明的目的是提供一种基于淀粉样蛋白和bgr的序列的肽; 肽，其可以诱导增强的免疫应答，并且对阿尔茨海默病的预防和治疗是安全有效的。 淀粉样蛋白 肽或其部分加入或插入半胱氨酸或半胱氨酸类似物，以及增强对淀粉样蛋白的免疫应答的方法; 使用所述肽，使用所述淀粉样蛋白来预防和治疗阿尔茨海默病的药物; 诱导增强的免疫应答的肽，以及包含编码淀粉样蛋白的基因的DNA疫苗; 肽或衍生自淀粉样蛋白的序列; 具有加入或插入半胱氨酸或半胱氨酸类似物的肽，如预期类似地有效。

    FLOW METER ADJUSTING METHOD, FLOW RATE MEASURING DEVICE AND ADJUSTMENT DATA CONTROLLING SYSTEM
    5.
    发明申请
    FLOW METER ADJUSTING METHOD, FLOW RATE MEASURING DEVICE AND ADJUSTMENT DATA CONTROLLING SYSTEM 有权
    流量计调整方法，流量测量装置和调整数据控制系统

    公开(公告)号：US20100236646A1

    公开(公告)日：2010-09-23

    申请号：US12664573

    申请日：2008-05-19

    申请人： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

    发明人： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

    IPC分类号： F16K37/00 ,  G01F25/00

    CPC分类号： G01F5/00 ,  G01F15/00 ,  G01F25/0007 ,  Y10T137/8158

    摘要： A body section having a main channel through which a fluid to be measured flows and sections for shunting the fluid to be measured from the main channel, and a fluid measuring section provided removably from the body section and measuring the flow rate of the fluid to be measured flowing through the main channel based on the detection results of the fluid to be measured introduced from the shunting section. The fluid measuring section is fixed to the body section and shunt ratio data, i.e. the adjustment data about measurement processing inherent to the constitution of the body section, is registered in the fluid measuring section before adjusting measurement processing.

    摘要翻译： 主体部分，其具有待测流体的主通道和用于从主通道分流待测量流体的部分;以及流体测量部，其从主体部分可拆卸地设置并且将流体的流量测量为 基于从分流部引入的待测量流体的检测结果，测量流过主通道的流量。 流体测量部分固定到主体部分，并且在调整测量处理之前将分流比数据，即关于身体部分的结构固有的测量处理的调节数据登记在流体测量部分中。

    Modified peptide vaccine derived from influenza M2
    6.
    发明授权
    Modified peptide vaccine derived from influenza M2 有权
    来自流感M2的改良肽疫苗

    公开(公告)号：US08883165B2

    公开(公告)日：2014-11-11

    申请号：US13392994

    申请日：2010-08-23

    申请人： Kazuyoshi Kaminaka ,  Chikateru Nozaki ,  Junichi Matsuda ,  Kiyoto Nishiyama

    发明人： Kazuyoshi Kaminaka ,  Chikateru Nozaki ,  Junichi Matsuda ,  Kiyoto Nishiyama

    IPC分类号： A61K39/12 ,  A61K39/00 ,  A61K39/385 ,  A61K39/145 ,  A61K38/00 ,  C07K17/00 ,  C07K14/005

    CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/55505 ,  C07K14/005 ,  C12N2760/16122 ,  C12N2760/16134

    摘要： A modified peptide derived from matrix protein 2 (hereinafter also referred to as “M2”), one of surface layer proteins of influenza virus, and a method for utilization of the modified peptide are provided. A peptide (hereinafter also referred to as “M2eC peptide”) that is made up by inserting cysteine residue(s) into a peptide (hereinafter also referred to as “M2e”) consisting of 23 amino acid residues of from positions No. 2 to No. 24 of M2 in influenza virus type A, a fusion protein consisting of said modified peptide and a polypeptide, an influenza vaccine comprising said modified peptide or said fusion protein as an active ingredient, a device which can be delivered into the body comprising said influenza vaccine, a nucleic acid fragment consisting of a nucleotide sequence encoding the amino acid sequence of said modified peptide or said fusion protein, an expression vector in which said nucleic acid fragment is incorporated, a host in which said expression vector is introduced, and an antibody that has a protective effect against influenza virus.

    摘要翻译： 提供了衍生自基质蛋白2的修饰肽（以下也称为“M2”），流感病毒的表层蛋白之一和使用修饰肽的方法。 通过将半胱氨酸残基插入由位置2〜23的23个氨基酸残基组成的肽（以下也称为“M2e”）而构成的肽（以下也称为“M2eC肽” 流感病毒A型M2的第24号，由所述修饰肽和多肽组成的融合蛋白，包含所述修饰肽或所述融合蛋白作为活性成分的流感疫苗，可以递送到身体的装置，包括所述 流感疫苗，由编码所述修饰肽或所述融合蛋白质的氨基酸序列的核苷酸序列组成的核酸片段，其中加入所述核酸片段的表达载体，导入所述表达载体的宿主和 对流感病毒具有保护作用的抗体。

    Flow meter adjusting method, flow rate measuring device and adjustment data controlling system
    7.
    发明授权
    Flow meter adjusting method, flow rate measuring device and adjustment data controlling system 有权
    流量计调节方法，流量测量装置和调整数据控制系统

    公开(公告)号：US08656752B2

    公开(公告)日：2014-02-25

    申请号：US12664573

    申请日：2008-05-19

    申请人： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

    发明人： Masanori Anzai ,  Junichi Matsuda ,  Manabu Muraoka

    IPC分类号： G01F25/00

    CPC分类号： G01F5/00 ,  G01F15/00 ,  G01F25/0007 ,  Y10T137/8158

    摘要： A body section having a main channel through which a fluid to be measured flows and sections for shunting the fluid to be measured from the main channel, and a fluid measuring section provided removably from the body section and measuring the flow rate of the fluid to be measured flowing through the main channel based on the detection results of the fluid to be measured introduced from the shunting section. The fluid measuring section is fixed to the body section and shunt ratio data, i.e. the adjustment data about measurement processing inherent to the constitution of the body section, is registered in the fluid measuring section before adjusting measurement processing.

    摘要翻译： 主体部分，其具有待测流体的主通道和用于从主通道分流待测量流体的部分;以及流体测量部，其从主体部分可拆卸地设置并且将流体的流量测量为 基于从分流部引入的待测量流体的检测结果，测量流过主通道的流量。 流体测量部分固定到主体部分，并且在调整测量处理之前将分流比数据，即关于身体部分的结构固有的测量处理的调节数据登记在流体测量部分中。

    Method for enhancing immune response with peptide
    8.
    发明授权
    Method for enhancing immune response with peptide 有权
    用肽增强免疫应答的方法

    公开(公告)号：US08623374B2

    公开(公告)日：2014-01-07

    申请号：US13220452

    申请日：2011-08-29

    申请人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    发明人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    IPC分类号： A61K38/17 ,  A61K39/00 ,  A61P37/04 ,  A61P25/00 ,  C07K14/435

    CPC分类号： A61K39/0007 ,  A61K31/711 ,  C07K14/4711

    摘要： An object of the present invention is to provide a safe and effective method for enhancing an immune response and a medicament for preventing or treating Alzheimer disease comprising amyloid β peptide that induces an enhanced immune response. An amyloid β peptide or a portion thereof with addition or insertion of cysteine and a method for enhancing an immune response using the peptide or a method for enhancing an immune response using the peptide together with an adjuvant. A medicament for preventing or treating Alzheimer disease comprising an amyloid β peptide or a portion thereof that induces an enhanced immune response. A DNA vaccine, that may have the same effect, comprising the gene encoding an amyloid β peptide or a portion thereof that induces an enhanced immune response with addition or insertion of cysteine.

    摘要翻译： 本发明的目的是提供一种用于增强免疫应答的安全有效的方法和用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽。 具有添加或插入半胱氨酸的淀粉样蛋白β肽或其部分，以及使用肽增强免疫应答的方法或使用肽与佐剂一起增强免疫应答的方法。 一种用于预防或治疗阿尔茨海默病的药物，其包含诱导增强的免疫应答的淀粉样蛋白β肽或其部分。 可以具有相同效果的DNA疫苗，其包含编码淀粉样蛋白β肽或其部分的基因，其通过加入或插入半胱氨酸诱导增强的免疫应答。

    Modified amyloid β peptide
    9.
    发明授权
    Modified amyloid β peptide 有权
    改良淀粉样β肽

    公开(公告)号：US08512709B2

    公开(公告)日：2013-08-20

    申请号：US13124260

    申请日：2009-10-16

    申请人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    发明人： Junichi Matsuda ,  Kazuyoshi Kaminaka ,  Chikateru Nozaki

    IPC分类号： A61K38/17 ,  A61K39/00 ,  A61P25/00 ,  A61P37/04 ,  C07K14/435

    CPC分类号： C07K14/4711 ,  A61K39/0007 ,  A61K2039/53

    摘要： An object of the invention is to provide a peptide based on a sequence of an amyloid β peptide that may allow for induction of enhanced immune response and is safe and efficacious for prophylaxis and treatment of Alzheimer disease. An amyloid β peptide or a portion thereof with addition or insertion of cysteine or a cysteine analogue, and a method for enhancing immune response to amyloid β using said peptide, a medicament for prophylaxis and treatment of Alzheimer disease using said amyloid β peptide that induces an enhanced immune response, and a DNA vaccine comprising a gene coding for an amyloid β peptide or a sequence derived from an amyloid β peptide with addition or insertion of cysteine or a cysteine analogue, as expected to be similarly efficacious.

    摘要翻译： 本发明的目的是提供一种基于淀粉样蛋白β肽序列的肽，其可以诱导增强的免疫应答，并且对于阿尔茨海默病的预防和治疗是安全有效的。 具有添加或插入半胱氨酸或半胱氨酸类似物的淀粉状蛋白β肽或其部分，以及使用所述肽增强对淀粉样蛋白β的免疫应答的方法，使用所述淀粉样蛋白β肽预防和治疗阿尔茨海默病的药物，所述淀粉样肽 增强的免疫应答，以及包含编码淀粉样蛋白β肽的基因或衍生自淀粉样蛋白β肽的序列的DNA疫苗，其具有加入或插入半胱氨酸或半胱氨酸类似物，如预期类似地有效的。

    Electric vehicle having drivetrain and suspension
    10.
    发明授权
    Electric vehicle having drivetrain and suspension 有权
    具有动力传动系和悬架的电动车

    公开(公告)号：US08453782B2

    公开(公告)日：2013-06-04

    申请号：US13282770

    申请日：2011-10-27

    申请人： Nobuyuki Kondo ,  Junichi Matsuda ,  Takasumi Yamanaka ,  Naoyoshi Honda ,  Izumi Kanazawa ,  Yuichiro Shimura

    发明人： Nobuyuki Kondo ,  Junichi Matsuda ,  Takasumi Yamanaka ,  Naoyoshi Honda ,  Izumi Kanazawa ,  Yuichiro Shimura

    IPC分类号： B60K6/42

    CPC分类号： B62M7/12 ,  B62K2202/00 ,  B62K2204/00

    摘要： An electric vehicle includes a vehicle body frame; an electric motor; a swing arm pivotally supporting a rear wheel at a rear end thereof; a drive shaft for transmitting the driving force of the electric motor to the wheel; and a suspension connecting the vehicle body frame and the swing arm together. The electric motor is set in a longitudinal layout in which a rotating drive shaft is disposed in a front-rear direction of the vehicle; and is offset from a center to either of left and right sides in a vehicle width direction. The suspension is disposed under the electric motor and the drive shaft, and on the inner sides of the electric motor and the drive shaft in the vehicle width direction, and overlapping the positions of the electric motor and the drive shaft in the front-rear direction.

    摘要翻译： 电动车辆包括车体框架; 电动马达 在其后端枢转地支撑后轮的摆臂; 用于将电动机的驱动力传递到车轮的驱动轴; 以及将车体框架和摆臂连接在一起的悬架。 电动机设置在纵向布局中，其中旋转驱动轴设置在车辆的前后方向上; 并且在车辆宽度方向上从中心向左右两侧偏移。 悬架设置在电动机和驱动轴下方，并且在电动机的内侧和车辆宽度方向上的驱动轴上，并且电动机和驱动轴的位置沿前后方向重叠 。