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公开(公告)号：US20130045197A1
公开(公告)日：2013-02-21
申请号：US13588210
申请日：2012-08-17
申请人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
发明人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
摘要： The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.
摘要翻译： 本发明涉及一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包含通过用酵母培养物接种藻类，江ia，特别是藻类，马鞭草属的生物质获得的肉汤，并允许 发酵生物质以产生发酵液。 还描述了一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包括藻类提取物，江孜草。 本发明还涉及包含作为化妆品和/或药物活性成分的化妆品和/或药物活性成分的发酵，藻类，江ia，特别是藻类，山楂，或藻类提取物，山茱萸，或两者的组合 。
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公开(公告)号：US09480864B2
公开(公告)日：2016-11-01
申请号：US13588210
申请日：2012-08-17
申请人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
发明人： Manasi Chavan , Yuhua Sun , Christine Williams , Michael Sunkin
摘要： The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.
摘要翻译： 本发明涉及一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包含通过用酵母培养物接种藻类，江ia，特别是藻类，马鞭草属的生物质获得的肉汤，并允许 发酵生物质以产生发酵液。 还描述了一种用于刺激皮肤细胞的蛋白酶体活性的化妆品和/或药物活性成分，其包括藻类提取物，江孜草。 本发明还涉及包含作为化妆品和/或药物活性成分的藻类，江ia（Gracilaria spp。），特别是藻类，山楂（Tacvahiae）或藻类提取物，山楂（Tacvahiae）或两者的组合的发酵物的局部组合物 。
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3.发明授权Stabilized proteases that have been immobilized and further crosslinked for use in skin care 有权稳定的蛋白酶已被固定并进一步交联用于皮肤护理公开(公告)号：US08778336B2
公开(公告)日：2014-07-15
申请号：US13009825
申请日：2011-01-19
申请人： Manasi Chavan
发明人： Manasi Chavan
CPC分类号： A61K8/66 , A61K38/4873 , A61K47/58 , A61K2800/57 , A61Q19/08 , C12N9/96 , C12Y304/22002
摘要： Disclosed is an invention which relates to synthesizing immobilized and crosslinked proteases derived from plants for use as skin care agents. The resulting stabilized protease will minimally penetrate the skin because of its immobilized nature. It will retain activity because of its crosslinked nature and, in certain embodiments, due to its stabilization via physical additives. The present invention relates in particular to a linked papain product used in topical skin applications.
摘要翻译： 本发明涉及合成来源于植物的固定和交联的蛋白酶用作皮肤护理剂的发明。 由于其固定化的性质，所得到的稳定的蛋白酶将最小程度地渗入皮肤。 它将由于其交联性质而保留活性，并且在某些实施方案中由于其通过物理添加剂而稳定。 本发明特别涉及用于局部皮肤应用的连接木瓜蛋白酶产品。
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