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公开(公告)号:US20190076530A1
公开(公告)日:2019-03-14
申请号:US16151678
申请日:2018-10-04
申请人: MannKind Corporation
发明人: Marshall Grant , Paul Menkin , Grayson W. Stowell
CPC分类号: A61K47/22 , A61K9/0075 , A61K9/14 , A61K9/50 , A61K38/28 , Y10T428/2982
摘要: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
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公开(公告)号:US09610351B2
公开(公告)日:2017-04-04
申请号:US14622660
申请日:2015-02-13
IPC分类号: A61K38/07 , A61K38/08 , A61K9/14 , C07K5/10 , C07K7/06 , A61K47/22 , A61K38/04 , A61K9/00 , A61K31/495 , A61K31/198 , A61K31/401 , A61K31/405 , C07K5/107
CPC分类号: A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
摘要: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
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公开(公告)号:US09630930B2
公开(公告)日:2017-04-25
申请号:US14251513
申请日:2014-04-11
申请人: MannKind Corporation
IPC分类号: A61K9/14 , C07D241/04 , C07D241/08 , A61K9/00 , A61K9/16 , A61K9/19 , A61K38/28 , A61K45/06 , A61M15/00 , A61K38/00
CPC分类号: A61K31/495 , A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1694 , A61K9/19 , A61K31/5575 , A61K38/00 , A61K38/193 , A61K38/28 , A61K45/06 , A61M15/0028 , A61M15/0091 , C07D241/08 , Y10T428/2982
摘要: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
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公开(公告)号:US09233159B2
公开(公告)日:2016-01-12
申请号:US14354092
申请日:2012-10-24
IPC分类号: A61K38/04 , A61K38/07 , A61K38/08 , A61K9/14 , C07K5/10 , C07K7/06 , A61K47/22 , A61K9/00 , A61K31/495 , A61K31/198 , A61K31/401 , A61K31/405 , C07K5/107
CPC分类号: A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
摘要: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
摘要翻译: 公开了治疗疼痛的方法和组合物。 所述组合物基于包含二酮哌嗪的微粒和止痛活性剂的干燥粉末。 组合物中的镇痛剂包含一种或多种肽止痛剂或其衍生物,其使用包含干粉吸入器和镇痛组合物的肺吸入药物递送系统施用于受试者。 本发明组合物产生与当前阿片样物质治疗相关的较少副作用。
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公开(公告)号:US20140315953A1
公开(公告)日:2014-10-23
申请号:US14306100
申请日:2014-06-16
申请人: MannKind Corporation
发明人: Andrea Leone-Bay , Grayson W. Stowell , Joseph J. Guarneri , Dawn M. Carlson , Marshall Grant , Chad C. Smutney
IPC分类号: A61K9/00 , A61K47/18 , A61K31/422 , A61K45/06 , A61K31/404 , A61K31/454 , A61K31/4045 , A61K31/4196
CPC分类号: A61K31/5575 , A61K9/0073 , A61K9/0075 , A61K9/1617 , A61K9/1688 , A61K31/404 , A61K31/4045 , A61K31/4196 , A61K31/422 , A61K31/454 , A61K31/495 , A61K38/26 , A61K45/06 , A61K47/183 , A61M15/0028 , A61M2202/064
摘要: A method for treating migraines is disclosed. The method utilizes a rapid drug delivery system which prevents deactivation or degradation of the active agent, including small molecules and peptides being administered to a patient in need of treatment. In particular, the drug delivery system is designed for inhalation for delivery of drugs to the pulmonary circulation in a rapid and therapeutically effective manner.
摘要翻译: 公开了一种治疗偏头痛的方法。 该方法利用快速的药物递送系统,其防止活性剂的失活或降解,包括向需要治疗的患者施用的小分子和肽。 特别地,药物递送系统被设计为用于以快速和治疗有效的方式将药物递送至肺循环的吸入。
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公开(公告)号:US20140302151A1
公开(公告)日:2014-10-09
申请号:US14354092
申请日:2012-10-24
CPC分类号: A61K38/08 , A61K9/0075 , A61K9/14 , A61K31/198 , A61K31/401 , A61K31/405 , A61K31/495 , A61K38/04 , A61K38/07 , A61K47/22 , C07K5/10 , C07K5/1016 , C07K7/06 , A61K2300/00
摘要: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
摘要翻译: 公开了治疗疼痛的方法和组合物。 所述组合物基于包含二酮哌嗪的微粒和止痛活性剂的干燥粉末。 组合物中的镇痛剂包含一种或多种肽止痛剂或其衍生物,其使用包含干粉吸入器和镇痛组合物的肺吸入药物递送系统施用于受试者。 本发明组合物产生与当前阿片样物质治疗相关的较少副作用。
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公开(公告)号:US20140045745A1
公开(公告)日:2014-02-13
申请号:US14017143
申请日:2013-09-03
申请人: MannKind Corporation
CPC分类号: A61K31/495 , A61K9/0075 , A61K9/145 , A61K9/1617 , A61K9/1694 , A61K9/19 , A61K31/5575 , A61K38/00 , A61K38/193 , A61K38/28 , A61K45/06 , A61M15/0028 , A61M15/0091 , C07D241/08 , Y10T428/2982
摘要: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
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公开(公告)号:US11607410B2
公开(公告)日:2023-03-21
申请号:US16994425
申请日:2020-08-14
申请人: MannKind Corporation
IPC分类号: A61K31/495 , A61K9/00 , A61K9/14 , A61K38/28 , A61P5/00 , A61K38/00 , A61K9/16 , A61K9/19 , A61K45/06 , A61M15/00 , C07D241/08 , A61K31/5575 , A61K38/19
摘要: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
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公开(公告)号:US20200375984A1
公开(公告)日:2020-12-03
申请号:US16994425
申请日:2020-08-14
申请人: MannKind Corporation
IPC分类号: A61K31/495 , A61K9/00 , A61K9/16 , A61K9/19 , A61K9/14 , A61K38/28 , A61K45/06 , A61M15/00 , C07D241/08 , A61K31/5575 , A61K38/19
摘要: Disclosed herein are diketopiperazine microparticles having a specific surface area of less than about 67 m2/g. The diketopiperazine microparticle can be fumaryl diketopiperazine and can comprise a drug such as insulin.
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公开(公告)号:US20200147221A1
公开(公告)日:2020-05-14
申请号:US16739506
申请日:2020-01-10
申请人: MannKind Corporation
发明人: Marshall Grant , Paul Menkin , Grayson W. Stowell
摘要: Disclosed herein are diketopiperazine microparticles having high capacity for adsorbing a drug or active agent. In particular, the diketopiperazine microparticle are formed using fumaryl diketopiperazine and can comprise a drug in large doses for the treatment of disease or disorders by pulmonary delivery via oral inhalation.
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