公开(公告)号：US08580251B2

公开(公告)日：2013-11-12

申请号：US12581314

申请日：2009-10-19

申请人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

发明人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

IPC分类号： A61K38/45 ,  A61K35/00 ,  C12N9/12

CPC分类号： C12Q1/6883 ,  C12N9/1205

摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

公开(公告)号：US07629126B2

公开(公告)日：2009-12-08

申请号：US11609652

申请日：2006-12-12

申请人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

发明人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

IPC分类号： C12Q1/68 ,  C12Q1/48 ,  C12N15/54

CPC分类号： C12Q1/6883 ,  C12N9/1205

摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。

公开(公告)号：US20070154919A1

公开(公告)日：2007-07-05

申请号：US11609652

申请日：2006-12-12

申请人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

发明人： Marc Korn ,  Guenter Mueller ,  Rudolf Schneider ,  Georg Tschank

IPC分类号： C12Q1/68 ,  C12Q1/48 ,  C07H21/04 ,  C12P21/06 ,  C12N9/12

CPC分类号： C12Q1/6883 ,  C12N9/1205

摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.

摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。