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公开(公告)号：US08580251B2
公开(公告)日：2013-11-12
申请号：US12581314
申请日：2009-10-19
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
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公开(公告)号：US07629126B2
公开(公告)日：2009-12-08
申请号：US11609652
申请日：2006-12-12
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。
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公开(公告)号：US20070154919A1
公开(公告)日：2007-07-05
申请号：US11609652
申请日：2006-12-12
申请人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marc Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。
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公开(公告)号：US07227006B2
公开(公告)日：2007-06-05
申请号：US10348081
申请日：2003-01-21
申请人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
发明人： Marcus Korn , Guenter Mueller , Rudolf Schneider , Georg Tschank
CPC分类号： C12Q1/6883 , C12N9/1205
摘要： The invention relates to isolated nucleic acid molecules and to host cells comprising such nucleic acid molecules. Moreover, the invention relates to a polypeptide having PIM-3 activity and having a definite amino acid sequence, as well as to the use of PIM-3 as a screening agent for identifying anti-type 2 diabetes mellitus drugs and for preparing a medicament for the treatment of insulin resistance or type 2 diabetes mellitus.
摘要翻译： 本发明涉及分离的核酸分子和宿主包含这种核酸分子的细胞。 此外，本发明涉及具有PIM-3活性并具有确定氨基酸序列的多肽，以及使用PIM-3作为鉴定抗2型糖尿病药物的筛选剂，并且用于制备用于 治疗胰岛素抵抗或2型糖尿病。
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公开(公告)号：US09644017B2
公开(公告)日：2017-05-09
申请号：US12820722
申请日：2010-06-22
申请人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
发明人： Paul Habermann , Gerhard Seipke , Roland Kurrle , Gunter Muller , Mark Sommerfeld , Norbert Tennagels , Georg Tschank , Ulrich Werner
摘要： The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the following features: a) the B chain end consists of an amidated basic amino acid residue such as lysine or arginine amide; b) the N-terminal amino acid residue of the insulin A chain is a lysine or arginine radical; c) the amino acid position A8 is occupied by a histidine radical; d) the amino acid position A21 is occupied by a glycine radical; and e) one or more substitutions and/or additions of negatively charged amino acid residues are carried out in the positions A5, A15, A18, B-1, B0, B1, B2, B3 and B4.
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6.发明申请BENZYL-OXATHIAZINE DERIVATIVES SUBSTITUTED WITH ADAMANTANE AND NORADAMANTANE, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF 有权用ADAMANTANE和NORADAMANTANE取代的苄基 - 氧化氮衍生物，含有化合物的药物及其用途公开(公告)号：US20130345207A1
公开(公告)日：2013-12-26
申请号：US14003498
申请日：2012-03-07
申请人： Thomas Boehme , Kurt Ritter , Christian Engel , Torsten Haack , Stefan Guessregen , Georg Tschank
发明人： Thomas Boehme , Kurt Ritter , Christian Engel , Torsten Haack , Stefan Guessregen , Georg Tschank
IPC分类号： C07D291/06 , A61K31/54
CPC分类号： C07D291/06 , A61K31/54 , C07D291/02
摘要： The invention relates to compounds of formula (I) and to the physiologically compatible salts thereof. Said compounds are suitable, for example, for treating hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上相容的盐。 所述化合物适用于例如治疗高血糖症。
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7.发明授权Bicyclic cyanoheterocycles, process for their preparation and their use as medicaments 有权双环氰基杂环，其制备方法及其用作药物公开(公告)号：US07008957B2
公开(公告)日：2006-03-07
申请号：US10898751
申请日：2004-07-26
申请人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Holger Wagner , Karl Schoenafinger , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： A61K31/428 , A61K31/454 , A61K31/5377 , C07D417/02 , C07D277/60
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I in which the radicals have the stated meanings, their stereoisomeric forms and their physiologically tolerated salts and process for their preparation. The compounds are suitable for the treatment of metabohlic disorders such as type 2 diabetes.
摘要翻译： 本发明涉及式Ⅰ化合物，其中基团具有所述含义，它们的立体异构形式及其生理上可耐受的盐及其制备方法。 该化合物适用于治疗代谢性疾病如2型糖尿病。
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8.发明申请Novel cyanopyrrolidides, process for their preparation and their use as medicaments 有权新型氰基吡咯烷酮，其制备方法及其作为药物的用途公开(公告)号：US20050059724A1
公开(公告)日：2005-03-17
申请号：US10898752
申请日：2004-07-26
申请人： Karl Schoenafinger , Holger Wagner , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
发明人： Karl Schoenafinger , Holger Wagner , Gerhard Jaehne , Holger Gaul , Christian Buning , Georg Tschank , Ulrich Werner
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D487/04
摘要： The invention relates to compounds of the formula I in which the radicals have the meanings stated in the text, their stereoisomeric forms, and their physiologically tolerated salts, physiologically functional derivatives and process for their preparation. The compounds are suitable for the treatment of disorders of metabolism, such as type 2 diabetes.
摘要翻译： 本发明涉及式I化合物，其中基团具有文中所述的含义，它们的立体异构形式及其生理学上可耐受的盐，生理功能衍生物及其制备方法。 该化合物适用于治疗代谢紊乱，如2型糖尿病。
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9.发明授权Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof 有权四取代的噻嗪衍生物，其制备方法，它们作为含有所述衍生物的药物和药物的用途及其用途公开(公告)号：US08871758B2
公开(公告)日：2014-10-28
申请号：US14003080
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/51 , A61K45/06 , C07D419/12 , C07D515/20 , A61K31/541 , A61K31/547 , C07D515/10 , C07D291/02 , C07D291/06 , A61K31/54 , C07D291/08
CPC分类号： C07D291/06 , A61K31/54 , A61K31/541 , A61K31/547 , A61K45/06 , C07D291/02 , C07D291/08 , C07D419/12 , C07D515/10 , C07D515/20
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上可接受的盐。 所述化合物是合适的。 用于治疗高血糖症。
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10.发明申请OXATHIAZINE DERIVATIVES WHICH ARE SUBSTITUTED WITH BENZYL OR HETEROMETHYLENE GROUPS, METHOD FOR PRODUCING THEM, THEIR USE AS MEDICINE AND DRUG CONTAINING SAID DERIVATIVES AND THE USE THEREOF 有权用苄基或异二甲苯基取代的氧化氮衍生物，其生产方法，用作含有所述衍生物的药物和药物及其用途公开(公告)号：US20140066437A1
公开(公告)日：2014-03-06
申请号：US14003392
申请日：2012-03-07
申请人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
发明人： Thomas Boehme , Christian Engel , Stefan Guessregen , Torsten Haack , Kurt Ritter , Georg Tschank
IPC分类号： A61K31/54 , A61K47/06 , C07D419/14 , C07D291/06 , C07D419/10
CPC分类号： A61K31/54 , A61K47/06 , C07D291/06 , C07D419/10 , C07D419/14
摘要： The invention relates to the compounds of formula (I) and to the physiologically acceptable salts thereof. Said compounds are suitable e.g. for the treatment of hyperglycemia.
摘要翻译： 本发明涉及式（I）化合物及其生理上可接受的盐。 所述化合物是合适的。 用于治疗高血糖症。
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