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公开(公告)号：US06824782B2
公开(公告)日：2004-11-30
申请号：US09791540
申请日：2001-02-26
IPC分类号： A61K39395
CPC分类号： G01N33/6857 , A61K47/60 , A61K2039/505 , C07K16/30 , C07K19/00 , C07K2317/41 , C07K2317/622 , C07K2319/00
摘要： The present invention relates to the chemical modification of single chain polypeptides by means of covalent attachment of strands of poly(ethylene glycol) PEG and similar poly(alkylene oxides) to single chain polypeptide binding molecules that have the three dimensional folding and, thus, the binding ability and specificity, of the variable region of an antibody. Such preparations of modified single chain polypeptide binding molecules have reduced immugenicity and antigenicity as well as having a longer halflife in the bloodstream as compared to the parent polypeptide. These beneficial properties of the modified single chain polypeptide binding molecules make them very useful in a variety of therapeutic applications. The invention also relates to multivalent antigen-binding molecules capable of PEGylation. Compositions of, genetic constructions for, methods of use, and methods for producing PEGylated antigen-binding proteins are disclosed.
摘要翻译： 本发明涉及通过将聚（乙二醇）PEG和类似的聚（环氧烷）的链共价连接到具有三维折叠的单链多肽结合分子的单链多肽的化学修饰，因此涉及 抗体的可变区的结合能力和特异性。 与亲本多肽相比，修饰的单链多肽结合分子的这种制剂具有降低的免疫性和抗原性，并且在血流中具有更长的半衰期。 修饰的单链多肽结合分子的这些有益性质使得它们在各种治疗应用中非常有用。 本发明还涉及能够进行PEG化的多价抗原结合分子。 公开了用于生产聚乙二醇化抗原结合蛋白的遗传构建，使用方法和方法的组合物。
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公开(公告)号：US5656730A
公开(公告)日：1997-08-12
申请号：US417855
申请日：1995-04-07
申请人： Lihsyng Stanford Lee
发明人： Lihsyng Stanford Lee
IPC分类号： A61K39/395 , C07K16/30
CPC分类号： A61K39/39591 , C07K16/3046
摘要： The present invention relates to a stabilized protein composition comprising a monomeric protein and a storage-stabilizing amount of sucrose, histidine or glycine, which is sufficient to inhibit aggregation of the protein molecules during freeze/thaw cycles, and methods therefor. More particularly, this invention relates to pharmaceutically-acceptable, single-chain antigen-binding protein compositions having increased frozen-storage stability, especially to freeze/thaw cycles.
摘要翻译： 本发明涉及包含单体蛋白质和储存稳定量的蔗糖，组氨酸或甘氨酸的稳定化蛋白质组合物，其足以在冷冻/融化循环期间抑制蛋白质分子的聚集及其方法。 更具体地说，本发明涉及药物上可接受的单链抗原结合蛋白组合物，其具有增加的冷冻储存稳定性，特别是冻融循环。
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公开(公告)号：US20100184655A1
公开(公告)日：2010-07-22
申请号：US12376333
申请日：2007-07-16
IPC分类号： A61K38/18 , C07K14/505 , A61P7/00
CPC分类号： C07K14/505 , A61K38/00
摘要： This invention relates to novel protein conjugates, in particular, to novel pegylated proteins, and their methods of making and use. One aspect of the present invention relates to pegylated-erythropoietin having greater clinical efficacy and stability during shipment and storage than current erythropoietin formulations.
摘要翻译： 本发明涉及新的蛋白质缀合物，特别是涉及新型聚乙二醇化蛋白质及其制备和使用方法。 本发明的一个方面涉及聚乙二醇化促红细胞生成素，其在运输和储存期间比目前的促红细胞生成素制剂具有更高的临床疗效和稳定性。
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公开(公告)号：US08765924B2
公开(公告)日：2014-07-01
申请号：US12376333
申请日：2007-07-16
CPC分类号： C07K14/505 , A61K38/00
摘要： This invention relates to novel protein conjugates, in particular, to novel pegylated proteins, and their methods of making and use. One aspect of the present invention relates to pegylated-erythropoietin having greater clinical efficacy and stability during shipment and storage than current erythropoietin formulations.
摘要翻译： 本发明涉及新的蛋白质缀合物，特别是涉及新型聚乙二醇化蛋白质及其制备和使用方法。 本发明的一个方面涉及聚乙二醇化促红细胞生成素，其在运输和储存期间比目前的促红细胞生成素制剂具有更高的临床疗效和稳定性。
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公开(公告)号：US5917021A
公开(公告)日：1999-06-29
申请号：US819033
申请日：1997-03-17
申请人： Lihsyng Stanford Lee
发明人： Lihsyng Stanford Lee
IPC分类号： A61K39/395 , C07K16/30 , C07K16/00
CPC分类号： A61K39/39591 , C07K16/3046
摘要： The present invention relates to a stabilized protein composition comprising a monomeric protein and a storage-stabilizing amount of sucrose, histidine or glycine, which is sufficient to inhibit aggregation of the protein molecules during freeze/thaw cycles, and methods therefor. More particularly, this invention relates to pharmaceutically-acceptable, single-chain antigen-binding protein compositions having increased frozen-storage stability, especially to freeze/thaw cycles.
摘要翻译： 本发明涉及包含单体蛋白质和储存稳定量的蔗糖，组氨酸或甘氨酸的稳定化蛋白质组合物，其足以在冷冻/融化循环期间抑制蛋白质分子的聚集及其方法。 更具体地说，本发明涉及药物上可接受的单链抗原结合蛋白组合物，其具有增加的冷冻储存稳定性，特别是冻融循环。
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