公开(公告)号：US20070259342A1

公开(公告)日：2007-11-08

申请号：US11125015

申请日：2005-05-09

申请人： Margaret Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

发明人： Margaret Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53 ,  C12N15/00 ,  C12N5/06 ,  C12P1/04

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.

摘要翻译： 本发明提供分离的核酸分子，称为BBAP核酸分子，其编码与非霍奇金淋巴瘤差异表达的BAL分子相互作用或结合的蛋白质。 本发明还提供反义核酸分子，含有BBAP核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及引入或破坏了BBAP基因的非人转基因动物。 本发明还进一步提供了分离的BBAP蛋白，融合蛋白，抗原肽和抗BBAP抗体。 还提供了使用本发明组合物的诊断方法。

公开(公告)号：US07112420B2

公开(公告)日：2006-09-26

申请号：US09957635

申请日：2001-09-19

申请人： Margaret A. Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

发明人： Margaret A. Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

IPC分类号： C12N15/00 ,  C12N15/85 ,  C12N15/63 ,  C07H21/04

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.

公开(公告)号：US07632660B2

公开(公告)日：2009-12-15

申请号：US11125015

申请日：2005-05-09

申请人： Margaret A. Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

发明人： Margaret A. Shipp ,  Ricardo Aguiar ,  Liqun Gu ,  Kunihiko Takeyama

IPC分类号： C12P21/00 ,  C07K14/00 ,  C07H21/04

CPC分类号： C07K14/47 ,  A01K2217/05 ,  C07K2319/00

摘要： The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing BBAP nucleic acid molecules, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a BBAP gene has been introduced or disrupted. The invention still further provides isolated BBAP proteins, fusion proteins, antigenic peptides and anti-BBAP antibodies. Diagnostic methods using compositions of the invention are also provided.