Calcium independent phosphatidylserine binding compounds for detecting phosphatidylserine positive cells

    公开(公告)号:US20240262865A1

    公开(公告)日:2024-08-08

    申请号:US18099258

    申请日:2023-01-19

    IPC分类号: C07K7/64 G01N33/58

    摘要: The present invention relates to the phosphatidylserine (PS) binding compound derivative and the fusion of PS binding compound with an arm compound. The present invention describes the methods of producing and using PS binding compound derivative and the fusion of PS binding compound with an arm compound by providing the functional group to couple with functional group containing fluorophore for multicolor flow cytometry and multiplex imaging; to conjugate with magnetic particle for depleting the PS positive cells; to couple with oligo comprising PCR handle sequence, and unique DNA barcode for PS positive cells and capture sequence for discriminating positive cells from live cells in Single-cell RNA sequencing.

    Orthopedic fastener for stabilization and fixation

    公开(公告)号:US10603077B2

    公开(公告)日:2020-03-31

    申请号:US12101752

    申请日:2008-04-11

    申请人: Hong Zhang Dan Sucato

    发明人: Hong Zhang Dan Sucato

    IPC分类号: A61B17/70 A61F2/44 A61B90/00

    摘要: The present invention includes an apparatus, kit and method for providing a bone fixation assembly for attachment to a bone to provide augmented support. The bone fixation assembly includes a screw having a screw head and a threaded shank. A first aperture is positioned about the screw head to receive a first longitudinal member and a first compression member that engages the first aperture to secure the first longitudinal member. The screw head has a second aperture positioned to receive a second longitudinal member and a second compression member that engages the second longitudinal member aperture to secure the second longitudinal member and provide augmented support.

    Mobile application management
    5.
    发明授权

    公开(公告)号:US09792585B2

    公开(公告)日:2017-10-17

    申请号:US13529077

    申请日:2012-06-21

    IPC分类号: G06Q10/10 G06F9/445

    CPC分类号: G06Q10/10 G06F8/65

    摘要: A computer-implemented method may include determining whether a computing device accessing an online application marketplace is associated with a particular business entity registered with the online application marketplace. The method may further include identifying applications that were selected by a representative of the particular business entity to be identified to users whose devices are determined to be associated with the particular business entity. The method may still further include providing data for displaying the applications and a control for downloading executable code for at least one of the applications, receiving an indication that the control has been selected by the user to download the executable code for the applications, and providing the executable code for the at least one of the applications.

    Spinal rod link reducer
    7.
    发明授权
    Spinal rod link reducer 有权
    脊柱连杆减速机

    公开(公告)号:US09408641B2

    公开(公告)日:2016-08-09

    申请号:US12364412

    申请日:2009-02-02

    申请人: Hong Zhang Dan Sucato

    发明人: Hong Zhang Dan Sucato

    IPC分类号: A61B17/70

    摘要: The present invention includes a rod link reducer of a spinal fixation system that includes a first and a second spinal rod manipulator; a first spinal rod manipulator joint connected to the first spinal rod manipulator and a second spinal rod manipulator joint connected to the second spinal rod manipulator; a first and a second translatable transverse shaft connected to the first and second joints, respectively; and a universal reducer connected to both the first and second translatable transverse shafts, wherein the universal reducer, the shafts and the linkers provide movement and temporary fixation of a spine that has been manipulated into a final position during spinal surgery.

    摘要翻译: 本发明包括一种脊椎固定系统的连杆减速器,其包括第一和第二脊柱杆操纵器; 连接到第一脊柱杆操纵器的第一脊椎杆操纵器接头和连接到第二脊柱杆操纵器的第二脊柱杆操纵器接头; 分别连接到第一和第二接头的第一和第二平移横向轴; 以及连接到第一和第二可平移横向轴的通用减速器,其中通用减速器,轴和连接器提供在脊柱手术期间被操纵到脊椎的最终位置的运动和临时固定。

    Intelligent data center cluster selection
    8.
    发明授权
    Intelligent data center cluster selection 有权
    智能数据中心集群选择

    公开(公告)号:US09389920B2

    公开(公告)日:2016-07-12

    申请号:US13462290

    申请日:2012-05-02

    申请人: Hong Zhang

    发明人: Hong Zhang

    IPC分类号: H04L29/08 G06F9/50

    摘要: A method and technique for autonomous selection of a Data Center Cluster (DCC) for fulfilling a cloud computing service request, including a technique for grouping data centers (DCs) in a cloud network according to a ranking of eligible DCCs based on selection criteria. In various embodiments, the selection criteria may include a cluster performance metric, a cluster resource equivalence metric, a balance of resource performance metric, a DCC load index, or combination thereof. Other aspects include techniques for computing/determining each of the selection criteria.

    摘要翻译: 一种用于自动选择用于实现云计算服务请求的数据中心集群(DCC)的方法和技术,包括根据选择标准根据合格DCC的排名在云网络中对数据中心(DC)进行分组的技术。 在各种实施例中,选择标准可以包括集群性能度量,集群资源等价度量,资源性能度量的平衡,DCC负载索引或其组合。 其他方面包括用于计算/确定每个选择标准的技术。

    Congestion mitigation and avoidance
    9.
    发明授权
    Congestion mitigation and avoidance 有权
    阻塞和避免拥塞

    公开(公告)号:US09350665B2

    公开(公告)日:2016-05-24

    申请号:US13601957

    申请日:2012-08-31

    IPC分类号: H04J1/16 H04L12/803

    CPC分类号: H04L47/125

    摘要: In one embodiment, a method is provided for congestion mitigation. In this method, a congestion level of data flows along a path is monitored relative to a threshold. Here, each data flow is associated with a flow identifier. Based on detection that the congestion level exceeds the threshold, the flow identifier of a number (e.g., one or more) of the data flows is changed to a different flow identifier. This change results in the number of the data flows redirected to a different path. In an alternate embodiment, another method is provided for congestion avoidance. In this method, a data flow transmitted along a single path is received, and the data flow is split into multiple micro data flows. A different flow identifier is then assigned to each micro data flow. This change results in the multiple micro data flows distributed along multiple different paths.

    摘要翻译: 在一个实施例中,提供了一种用于拥塞缓解的方法。 在该方法中,相对于阈值监视沿着路径的数据流的拥塞级别。 这里,每个数据流与流标识符相关联。 基于拥塞级别超过阈值的检测,数据流(例如,一个或多个)的流标识被改变为不同的流标识符。 此更改导致重定向到不同路径的数据流的数量。 在替代实施例中,提供了另一种用于拥塞避免的方法。 在该方法中,接收沿着单个路径发送的数据流,并将数据流分割为多个微数据流。 然后将不同的流标识符分配给每个微数据流。 这种变化导致沿着多个不同路径分布的多个微数据流。

    Fault protection and correction of line and load faults
    10.
    发明授权
    Fault protection and correction of line and load faults 有权
    线路和负载故障的故障保护和校正

    公开(公告)号:US09306446B2

    公开(公告)日:2016-04-05

    申请号:US13708741

    申请日:2012-12-07

    摘要: A fault protection and correction circuit for the control of a power converter is disclosed. An example circuit generates a waveform that drives a switch on or off and controls the power converter. The controller circuit in addition to power factor correction (PFC) circuitry includes a first and a second shut down mode modules, both of them cause the switching to stop. The circuit includes a module for receiving fault events. When a fault occurs, the controller enters the second shut down mode. The controller stays in the second shut down mode if the required current for this mode can be provided by the outside circuitry. Otherwise, the controller enters the first shut down mode that requires less current and subsequently restarts the controller. By modifying the outside circuitry the controller can respond differently to fault events.

    摘要翻译: 公开了一种用于控制功率转换器的故障保护和校正电路。 示例电路产生驱动开关打开或关闭并控制功率转换器的波形。 除了功率因数校正(PFC)电路之外,控制器电路包括第一和第二关断模式模块,它们都导致切换停止。 该电路包括用于接收故障事件的模块。 当发生故障时,控制器进入第二个关闭模式。 如果外部电路可以提供该模式所需的电流,则控制器保持在第二关闭模式。 否则,控制器进入需要较少电流的第一关闭模式,然后重新启动控制器。 通过修改外部电路,控制器可以对故障事件做出不同的响应。