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    Process for the preparation of chirally pure n-(trans-4-is
    1.
    发明申请
    Process for the preparation of chirally pure n-(trans-4-is 失效
    手性纯的n-（反式-4-异构体）的制备方法

    公开(公告)号：US20070043117A1

    公开(公告)日：2007-02-22

    申请号：US10564017

    申请日：2004-07-08

    申请人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Torley ,  Monika Babjak

    发明人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Torley ,  Monika Babjak

    IPC分类号： A61K31/198 ,  C07C237/20

    CPC分类号： C07C233/63 ,  C07C231/12 ,  C07C231/24

    摘要： The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.

    摘要翻译： 本发明涉及新型晶型“G”中的N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸（那格列奈）及其制备方法。 还提供了通过用碱处理其低级烷基酯以产生碱金属盐并通过适当添加酸从所述盐释放产物来制备手性纯奈格列奈的方法。 本发明的另一方面是从那格列奈的其他结晶修饰物制备结晶形式“H”的那格列奈的方法。

    PROCESS FOR THE PREPARATION OF CHIRALLY PURE NATEGLINIDE
    2.
    发明申请
    PROCESS FOR THE PREPARATION OF CHIRALLY PURE NATEGLINIDE 审中-公开
    制备纯丙烯酰氯的方法

    公开(公告)号：US20100256414A1

    公开(公告)日：2010-10-07

    申请号：US12755572

    申请日：2010-04-07

    申请人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Törley ,  Monika Babjak

    发明人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Törley ,  Monika Babjak

    IPC分类号： C07C229/36

    CPC分类号： C07C233/63 ,  C07C231/12 ,  C07C231/24

    摘要： The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.

    摘要翻译： 本发明涉及新型晶型“G”中的N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸（那格列奈）及其制备方法。 还提供了通过用碱处理其低级烷基酯以产生碱金属盐并通过适当添加酸从所述盐释放产物来制备手性纯奈格列奈的方法。 本发明的另一方面是从那格列奈的其他结晶修饰物制备结晶形式“H”的那格列奈的方法。

    Process for the preparation of chirally pure N-(trans-4-is)
    3.
    发明授权
    Process for the preparation of chirally pure N-(trans-4-is) 失效
    手性纯N-（反式-4-异构体）的制备方法

    公开(公告)号：US07767847B2

    公开(公告)日：2010-08-03

    申请号：US10564017

    申请日：2004-07-08

    申请人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Törley ,  Monika Babjak

    发明人： Maria Gazdag ,  Tibor Gizur ,  Bela Hegedus ,  Attila Szemzo ,  Gabor Tarkanyi ,  Jozsef Törley ,  Monika Babjak

    IPC分类号： C07C229/00

    CPC分类号： C07C233/63 ,  C07C231/12 ,  C07C231/24

    摘要： The invention relates to N-(trans-4-isopropylcyclohexylcarbonyl)-D-phenylalanine (nateglinide) in the novel crystalline form “G” and a process for the preparation thereof. A process for the preparation of chirally pure nateglinide by treating a lower alkyl ester thereof with a base to yield an alkali salt and liberating the product from said salt by proper addition of an acid, is also provided. Still another aspect of the invention is a process for the preparation of nateglinide in the crystalline form “H” from other crystalline modifications of nateglinide.

    摘要翻译： 本发明涉及新型晶型“G”中的N-（反式-4-异丙基环己基羰基）-D-苯丙氨酸（那格列奈）及其制备方法。 还提供了通过用碱处理其低级烷基酯以产生碱金属盐并通过适当添加酸从所述盐释放产物来制备手性纯奈格列奈的方法。 本发明的另一方面是从那格列奈的其他结晶修饰物制备结晶形式“H”的那格列奈的方法。