公开(公告)号：US09700656B2

公开(公告)日：2017-07-11

申请号：US14492393

申请日：2014-09-22

申请人： Upma Sharma ,  Irina Gitlin ,  Gregory T. Zugates ,  Adam Rago ,  Parisa Zamiri ,  Rany Busold ,  Toby Freyman ,  Robert J. Caulkins ,  Quynh P. Pham ,  Changchen You ,  Jeffrey D. Carbeck

发明人： Upma Sharma ,  Irina Gitlin ,  Gregory T. Zugates ,  Adam Rago ,  Parisa Zamiri ,  Rany Busold ,  Toby Freyman ,  Robert J. Caulkins ,  Quynh P. Pham ,  Changchen You ,  Jeffrey D. Carbeck

IPC分类号： A61F2/02 ,  A61L31/06 ,  A61J1/20 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/14 ,  A61M37/00 ,  A61B17/12

CPC分类号： A61L31/06 ,  A61B17/12031 ,  A61B17/12163 ,  A61B17/12186 ,  A61B2017/12004 ,  A61J1/2093 ,  A61L27/18 ,  A61L27/56 ,  A61L27/58 ,  A61L31/141 ,  A61L31/146 ,  A61L31/148 ,  A61L2400/04 ,  A61L2400/06 ,  A61L2400/18 ,  A61M37/00 ,  C08L63/00 ,  C08L67/04

摘要： Systems and methods related to polymer foams are generally described. Some embodiments relate to compositions and methods for the preparation of polymer foams, and methods for using the polymer foams. The polymer foams can be applied to a body cavity and placed in contact with, for example, tissue, injured tissue, internal organs, etc. In some embodiments, the polymer foams can be formed within a body cavity (i.e., in situ foam formation). In addition, the foamed polymers may be capable of exerting a pressure on an internal surface of a body cavity and preventing or limiting movement of a bodily fluid (e.g., blood, etc.).

公开(公告)号：US08993831B2

公开(公告)日：2015-03-31

申请号：US13536557

申请日：2012-06-28

申请人： Upma Sharma ,  Irina Gitlin ,  Parisa Zamiri ,  Toby Freyman ,  Rany Busold ,  Lee Core ,  Janet Chie Komatsu ,  Jennifer Mortensen

发明人： Upma Sharma ,  Irina Gitlin ,  Parisa Zamiri ,  Toby Freyman ,  Rany Busold ,  Lee Core ,  Janet Chie Komatsu ,  Jennifer Mortensen

IPC分类号： A61F13/53 ,  A61K47/34 ,  A61P7/04 ,  A61K9/00 ,  A61L24/00 ,  A61L24/04 ,  A61L27/14 ,  A61L27/56 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61L24/0015 ,  A61L24/0036 ,  A61L24/046 ,  A61L27/14 ,  A61L27/56 ,  A61L31/04 ,  A61L31/146 ,  A61L2300/418 ,  A61L2400/04 ,  A61L2430/22 ,  C08L75/04

摘要： Medical implants and methods useful in treating postpartum hemorrhage are disclosed. The implants, in some embodiments, comprise polyurethane foams having advantageous mechanical and other properties selected to promote hemostasis when brought in contact with an inner wall of a uterus. Methods of making and deploying such implants are also disclosed.

摘要翻译： 公开了用于治疗产后出血的医疗植入物和方法。 在一些实施方案中，植入物包含具有有利的机械和其它性质的聚氨酯泡沫，当与子宫的内壁接触时，其被选择用于促进止血。 还公开了制造和部署这种植入物的方法。

公开(公告)号：US20140227340A1

公开(公告)日：2014-08-14

申请号：US14211900

申请日：2014-03-14

申请人： Toby Freyman ,  Quynh Pham ,  Robert F. Mulligan ,  Abby N. Picard ,  Xuri Yan

发明人： Toby Freyman ,  Quynh Pham ,  Robert F. Mulligan ,  Abby N. Picard ,  Xuri Yan

IPC分类号： A61K9/70 ,  A61K47/34 ,  A61K31/496 ,  D01D5/00 ,  A61K38/18

CPC分类号： A61K9/70 ,  A61K31/496 ,  A61K38/1825 ,  A61K47/34 ,  D01D5/0069 ,  D01D5/34 ,  D01F1/10 ,  D06M15/03

摘要： The present invention relates generally to the field of electrospun fibers. In particular, the present invention relates to core-sheath fibers and related electrospinning methods. The fibers of the invention comprise poorly water soluble drugs and/or proteins.

摘要翻译： 本发明一般涉及电纺纤维领域。 特别地，本发明涉及芯鞘纤维和相关的静电纺丝方法。 本发明的纤维包含水溶性差的药物和/或蛋白质。

公开(公告)号：US20130317418A1

公开(公告)日：2013-11-28

申请号：US13815910

申请日：2013-03-15

申请人： Toby Freyman ,  Joseph Lomakin ,  John Marini ,  Jennifer Mortensen ,  Adam Rago ,  Rany Busold ,  Upma Sharma ,  Gregory T. Zugates

发明人： Toby Freyman ,  Joseph Lomakin ,  John Marini ,  Jennifer Mortensen ,  Adam Rago ,  Rany Busold ,  Upma Sharma ,  Gregory T. Zugates

IPC分类号： A61M37/00

CPC分类号： A61B17/12181 ,  A61B17/12113 ,  A61B17/12118 ,  A61B17/1214 ,  A61B2017/1205 ,  A61F2/07 ,  A61F2002/065 ,  A61F2002/077 ,  A61F2210/0085 ,  A61J1/2093 ,  A61L24/0036 ,  A61L24/0089 ,  A61L24/046 ,  A61L31/06 ,  A61L31/128 ,  A61L31/146 ,  A61L2300/60 ,  A61L2400/06 ,  A61M37/00 ,  C08L67/04 ,  C08L83/04

摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.

摘要翻译： 公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。 这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。 当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。

公开(公告)号：US20110130715A1

公开(公告)日：2011-06-02

申请号：US13022217

申请日：2011-02-07

申请人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

发明人： Maria Palasis ,  Wendy Naimark ,  Toby Freyman ,  Samuel Epstein

IPC分类号： A61M5/00

CPC分类号： A61M11/06 ,  A61M25/0054 ,  A61M2025/0057

摘要： The present invention provides a catheter and catheter assembly for delivering micronized therapeutic agents to a target site in the body and, in particular, to a target site in the heart. The micronized therapeutic agents are delivered in aerosol form or dry powder form. The present invention also provides a method of delivering micronized therapeutic agents to a target site in the body by placing the therapeutic agents in a catheter, positioning the catheter in the target site, and exposing the therapeutic agents to an energizing mechanism sufficient to create supersonic flow to carry the therapeutic agents from a stationary state in the catheter to a mobile state towards the target site.

摘要翻译： 本发明提供一种导管和导管组件，用于将微粉化的治疗剂递送到身体中的靶部位，特别是向心脏中的靶位点递送。 微粉化治疗剂以气溶胶形式或干粉形式递送。 本发明还提供了一种通过将治疗剂放置在导管中将微粉化治疗剂递送到体内的靶位点的方法，将导管定位在靶位点，并将治疗剂暴露于足以产生超音速流动的激励机制 将治疗剂从导管中的静止状态运送到朝向目标部位的移动状态。

公开(公告)号：US07803141B2

公开(公告)日：2010-09-28

申请号：US10638426

申请日：2003-08-12

申请人： Samuel J. Epstein ,  Wendy Naimark ,  Toby Freyman

发明人： Samuel J. Epstein ,  Wendy Naimark ,  Toby Freyman

IPC分类号： A61M5/00

CPC分类号： A61M25/00 ,  A61M25/0023 ,  A61M25/0068 ,  A61M25/0074 ,  A61M25/0082 ,  A61M2025/0057 ,  A61M2025/0073

摘要： A device, system, and method for direct delivery of a therapeutic to a target site that utilizes the non-Newtonian characteristics of shear thinning and shear thickening to allow easy passage of a therapeutic through a delivery lumen yet facilitate retention of the therapeutic in the target site. The device, system, and method includes increasing the shear rate or shear stress of a non-Newtonian fluid having therapeutic properties thereby increasing or decreasing the viscosity of the non-Newtonian fluid.

摘要翻译： 用于将治疗剂直接递送到靶位点的装置，系统和方法，其利用剪切稀化和剪切增厚的非牛顿特性，以允许治疗剂容易地通过输送腔，而促进治疗剂保留在靶 现场。 装置，系统和方法包括增加具有治疗性质的非牛顿流体的剪切速率或剪切应力，从而增加或降低非牛顿流体的粘度。

公开(公告)号：US20080085294A1

公开(公告)日：2008-04-10

申请号：US11538683

申请日：2006-10-04

申请人： Toby Freyman ,  Robert Herrmann ,  Wendy Naimark ,  Maria Palasis

发明人： Toby Freyman ,  Robert Herrmann ,  Wendy Naimark ,  Maria Palasis

IPC分类号： A61F2/00

CPC分类号： A61L31/16 ,  A61L31/148 ,  A61L2300/604

摘要： This invention comprises an apparatus for treating an atherosclerotic plaque in a coronary artery of a mammal by placing at or proximate to an entrance to the coronary artery and upstream of the vulnerable plaque, and an effective amount of a therapeutic agent for the treatment of the plaque. This invention comprises delivering a deposition of a therapeutic drug high in the coronary arterial tree for treatment of downstream vulnerable plaques. The invention also comprises slow release formulation and delivery of an apparatus that is totally degradable or removed and/or replaced.

摘要翻译： 本发明包括一种用于通过放置在冠状动脉入口处或接近于冠状动脉入口处和易损斑块上游来治疗哺乳动物冠状动脉中的动脉粥样硬化斑块的装置，以及有效量的用于治疗斑块的治疗剂 。 本发明包括在冠状动脉树中输送高度治疗药物的沉积物以治疗下游脆弱斑块。 本发明还包括缓释制剂和递送完全可降解或除去和/或更换的装置。

公开(公告)号：US20080039786A1

公开(公告)日：2008-02-14

申请号：US11780885

申请日：2007-07-20

申请人： Samuel J. EPSTEIN ,  Toby FREYMAN ,  Chad G. HARRIS ,  Timothy J. MICKLEY

发明人： Samuel J. EPSTEIN ,  Toby FREYMAN ,  Chad G. HARRIS ,  Timothy J. MICKLEY

IPC分类号： A61M25/10

CPC分类号： A61M29/02 ,  A61B17/12022 ,  A61B17/1204 ,  A61B17/12104 ,  A61B17/12131 ,  A61B17/12172 ,  A61B2017/1205 ,  A61M2025/0024 ,  A61M2025/1052 ,  A61M2025/1081 ,  A61M2025/1095

摘要： The invention provides devices that can be used to deliver a therapeutic agent to a treatment site within the vessel of a patient at increased pressure, while limiting the contact with and pressure placed on the vessel walls. Devices according to the invention include an expandable structure arranged around and on a tube having a lumen. The expandable structure may include a sealing ring that makes contact with the interior surface of a vessel to prevent or decrease fluid flow during delivery of a therapeutic agent. This allows delivery of a therapeutic agent with decreased risk of injury to the treatment site. The invention also provides for large lumen diameters, preventing shearing stress on therapeutic agents such as cell slurries.

摘要翻译： 本发明提供了可用于将治疗剂递送到患者血管内的治疗部位的装置，所述治疗部位在增加的压力下同时限制与血管壁上的接触和压力。 根据本发明的装置包括布置在具有内腔的管周围和管上的可扩张结构。 可膨胀结构可包括与血管内表面接触以防止或减少递送治疗剂期间的流体流动的密封环。 这允许递送具有降低治疗部位损伤风险的治疗剂。 本发明还提供大的管腔直径，防止治疗剂如细胞浆液的剪切应力。

公开(公告)号：US07326571B2

公开(公告)日：2008-02-05

申请号：US10622674

申请日：2003-07-17

申请人： Toby Freyman

发明人： Toby Freyman

IPC分类号： C12N5/00 ,  C12N5/08

CPC分类号： A61L27/3683 ,  A61K35/28 ,  A61K38/00 ,  A61L27/28 ,  A61L27/3633 ,  A61L31/08

摘要： The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.

摘要翻译： 本发明涉及包含脱细胞的骨髓细胞外基质及其用途的组合物。 还提供了使用本发明的脱细胞化骨髓细胞外基质修复或再生受治疗者，优选人的有缺陷，患病，损伤或缺血组织或器官的方法。 本发明进一步涉及医疗装置，优选支架或人造心脏，以及生物相容性材料，优选组织再生支架，其包括用于植入受试者的脱细胞骨髓细胞外基质。

公开(公告)号：US20080021382A1

公开(公告)日：2008-01-24

申请号：US11879057

申请日：2007-07-16

申请人： Toby Freyman

发明人： Toby Freyman

IPC分类号： A61M25/10

CPC分类号： A61M25/0075 ,  A61F2/2403 ,  A61F2/2412 ,  A61F2/2424 ,  A61F2/2433 ,  A61F2/2496 ,  A61F2250/0059 ,  A61M25/0029 ,  A61M25/007 ,  A61M25/1002 ,  A61M25/1011 ,  A61M2025/0034 ,  A61M2025/0076 ,  A61M2025/1047 ,  A61M2025/105 ,  A61M2025/1072

摘要： The invention provides a catheter for insertion into a biological passage which contains a first flowing fluid, the catheter including a tubular member having a proximal end and a distal end; a fluid delivery lumen contained within the tubular member; an inflatable balloon assembly disposed at the distal end of the tubular member, the balloon assembly including an inflatable balloon member having an uninflated state and an inflated state, the balloon assembly including apertures in communication with the fluid delivery lumen; an inflation lumen in communication with the balloon member; and a valve contained within the inflatable balloon assembly. The inflatable balloon is assembly configured such that when the balloon member is in the inflated state: (i) sections of the balloon member contact the biological passage defining at least one containment pocket; (ii) the apertures are disposed in the containment pocket, (iii) a flow lumen is defined through the balloon member to allow the first fluid to flow through the balloon member; and (iv) the valve functions to allow the first flowing fluid to flow through the flow lumen in a physiologic direction, while blocking backflow of the first fluid through the flow lumen.

摘要翻译： 本发明提供一种用于插入生物通道中的导管，其包含第一流动流体，该导管包括具有近端和远端的管状构件; 容纳在管状构件内的流体输送腔; 设置在所述管状构件的远端的可充气球囊组件，所述球囊组件包括具有未膨胀状态和膨胀状态的可膨胀球囊构件，所述球囊组件包括与所述流体输送腔连通的孔; 与球囊构件连通的通气腔; 以及包含在可充气球囊组件内的阀。 充气气囊被组装成使得当球囊构件处于充气状态时：（i）球囊构件的部分接触限定至少一个容纳口袋的生物通道; （ii）孔口设置在容纳袋中，（iii）流动腔通过球囊构件限定，以允许第一流体流过球囊构件; 和（iv）所述阀的功能是允许所述第一流动流体在生理方向上流过所述流动腔，同时阻止所述第一流体通过所述流动腔的回流。