-
1.发明申请BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑-4,7-二酮，衍生物及其作为CDC25磷酸盐抑制剂的用途公开(公告)号：US20090131428A1
公开(公告)日：2009-05-21
申请号：US12246294
申请日：2008-10-06
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/423 , C07D263/54 , C07D413/02 , A61P35/00 , A61P31/12 , A61P29/00 , A61P37/00 , A61P25/00 , A61K31/5377 , A61K31/496
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
-
2.发明授权Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮衍生物及其作为dcd25磷酸酶抑制剂的用途公开(公告)号：US07279467B2
公开(公告)日：2007-10-09
申请号：US10500411
申请日：2002-12-24
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物
-
3.发明申请BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑和苯并恶唑-4,7-二酮，衍生物及其用作CDC25磷酸盐抑制剂公开(公告)号：US20090082345A1
公开(公告)日：2009-03-26
申请号：US12245549
申请日：2008-10-03
申请人： Marie-Odile GALCERA CONTOUR , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile GALCERA CONTOUR , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/497 , A61K31/428 , A61K31/5377
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
-
4.发明申请Benzothiazole-4,7-diones and benzoxazole-4,7-diones with substituents in position 5 or 6 and method for production thereof 失效在5或6位具有取代基的苯并噻唑-4,7-二酮和苯并恶唑-4,7-二酮及其制备方法公开(公告)号：US20060135573A1
公开(公告)日：2006-06-22
申请号：US10562949
申请日：2004-06-24
IPC分类号： A61K31/428 , A61K31/423 , C07D277/62 , C07D263/60
CPC分类号： C07D417/04 , C07D277/66 , C07D417/12 , C07D417/14
摘要： A subject of the invention is a selective process for the preparation of derivatives of benzothiazole-4,7-diones and benzoxazole-4,7-diones monosubstituted in position 5 or in position 6 by an amino group itself optionally substituted. Said derivatives are inhibitors of the Cdc25 phosphatases and can be used for preparing medicaments intended to treat cancer. The invention also offers synthesis intermediates which are useful in implementing the process of the invention. The invention also relates in particular to the following derivatives of benzothiazole-4,7-diones: 2-(2-chloro-6-fluorophenyl)-5-{[2-(dimethylamino)ethyl]amino}-1,3-benzothiazole-4,7-dione; 2-(2-chloro-6-fluorophenyl)-5-[(2-pyrrolidin-1-ylethyl)amino]-1,3-benzothiazole-4,7-dione.
摘要翻译： 本发明的主题是制备苯并噻唑-4,7-二酮衍生物的选择性方法和在5位或6位上单取代的苯并恶唑-4,7-二酮本身任选取代的氨基。 所述衍生物是Cdc25磷酸酶的抑制剂，可用于制备用于治疗癌症的药物。 本发明还提供了可用于实施本发明方法的合成中间体。 本发明还特别涉及苯并噻唑-4,7-二酮的以下衍生物：2-（2-氯-6-氟苯基）-5 - {[2-（二甲基氨基）乙基]氨基} -1,3-苯并噻唑 -4,7-二酮 2-（2-氯-6-氟苯基）-5 - [（2-吡咯烷-1-基乙基）氨基] -1,3-苯并噻唑-4,7-二酮。
-
5.发明申请Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮衍生物及其作为dcd25磷酸酶抑制剂的用途公开(公告)号：US20060040996A1
公开(公告)日：2006-02-23
申请号：US10500411
申请日：2002-12-24
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marrie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marrie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/428 , A61K31/423
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
-
6.发明授权Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮，它们作为cdc25磷酸盐抑制剂的用途公开(公告)号：US07495021B2
公开(公告)日：2009-02-24
申请号：US11849092
申请日：2007-08-31
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428 , C07D277/64 , C07D277/66
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
-
7.发明授权Benzothiazole-4,7-diones and benzoxazole-4,7-diones with substituents in position 5 or 6 and method for production thereof 失效在5或6位具有取代基的苯并噻唑-4,7-二酮和苯并恶唑-4,7-二酮及其制备方法公开(公告)号：US07335674B2
公开(公告)日：2008-02-26
申请号：US10562949
申请日：2004-06-24
IPC分类号： A61K31/423 , A61K31/438 , C07D277/64 , C07D277/66 , C07D263/56 , C07D263/57
CPC分类号： C07D417/04 , C07D277/66 , C07D417/12 , C07D417/14
摘要： A targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted.
摘要翻译： 苯并噻唑-4,7-二酮和苯并恶唑-4,7-二酮衍生物的靶向制备方法，其在5或6位被单取代，具有氨基，本身任选被取代。
-
8.发明申请BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑和苯并恶唑-4,7-二酮，衍生物及其用作CDC25磷酸盐抑制剂公开(公告)号：US20070255063A1
公开(公告)日：2007-11-01
申请号：US11752180
申请日：2007-05-22
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： C07D277/62 , C07D263/54
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Heterocyclic dione compounds as disclosed in the specification, compositions thereof and methods for the use thereof, for the treatment of T cell-mediated conditions such as autoimmune diseases and organ graft rejection.
摘要翻译： 本说明书，其组合物及其使用方法中所公开的杂环二酮化合物，用于治疗T细胞介导的病症如自身免疫性疾病和器官移植排斥。
-
公开(公告)号：US07012079B1
公开(公告)日：2006-03-14
申请号：US09806952
申请日：2000-02-24
申请人： Olivier Lavergne , Dennis Bigg , Christophe Lanco , Alain Rolland
发明人： Olivier Lavergne , Dennis Bigg , Christophe Lanco , Alain Rolland
IPC分类号： C07D491/14 , C07D491/22 , A61K31/44
CPC分类号： C07D491/22
摘要： The invention relates in particular to the compounds of general formula in which R1, R2, R3, R4, R5, R6 represent various radicals; their use as medicaments and pharmaceutical compositions containing them. These compounds are particularly useful for the treatment of cancer.
摘要翻译： 本发明特别涉及通式的化合物，其中R 1，R 2，R 3，R 4， R 5，R 5，R 6代表各种基团; 它们用作药物和含有它们的药物组合物。 这些化合物特别可用于治疗癌症。
-
10.发明申请New analogues of camptothecin, their use as medicaments and the pharmaceutical compositions containing them 有权喜树碱的新类似物，它们作为药物的用途和含有他们的药物组合物公开(公告)号：US20050038064A1
公开(公告)日：2005-02-17
申请号：US10930622
申请日：2004-08-31
申请人： Dennis Bigg , Olivier Lavergne , Francesc Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
发明人： Dennis Bigg , Olivier Lavergne , Francesc Rodas , Jacques Pommier , Gerard Ulibarri , Jerry Harnett , Alain Rolland , Anne-Marie Liberatore , Christophe Lanco , Jean-Bernard Cazaux , Christine Le Breton , Eric Manginot
IPC分类号： C07D213/61 , C07D213/64 , C07D471/14 , C07D491/04 , C07D491/22 , C07D498/22
CPC分类号： C07D213/64 , C07D213/61 , C07D471/14 , C07D491/04
摘要： A compound of the formula wherein the substituents are defined as in the specification which compounds are useful in the treatment of cancer.
摘要翻译： 下式的化合物，其中取代基如本说明书中所定义，其中该化合物可用于治疗癌症。
-
-
-
-
-
-
-
-
-
搜索结果
24 条记录 (耗时 0.022 秒)
