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1.发明申请BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑-4,7-二酮，衍生物及其作为CDC25磷酸盐抑制剂的用途公开(公告)号：US20090131428A1
公开(公告)日：2009-05-21
申请号：US12246294
申请日：2008-10-06
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/423 , C07D263/54 , C07D413/02 , A61P35/00 , A61P31/12 , A61P29/00 , A61P37/00 , A61P25/00 , A61K31/5377 , A61K31/496
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
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2.发明申请BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑和苯并恶唑-4,7-二酮，衍生物及其用作CDC25磷酸盐抑制剂公开(公告)号：US20090082345A1
公开(公告)日：2009-03-26
申请号：US12245549
申请日：2008-10-03
申请人： Marie-Odile GALCERA CONTOUR , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile GALCERA CONTOUR , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/497 , A61K31/428 , A61K31/5377
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
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3.发明申请BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 审中-公开苯并噻唑和苯并恶唑-4,7-二酮，衍生物及其用作CDC25磷酸盐抑制剂公开(公告)号：US20070255063A1
公开(公告)日：2007-11-01
申请号：US11752180
申请日：2007-05-22
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： C07D277/62 , C07D263/54
CPC分类号： C07D413/04 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/56 , C07D263/57 , C07D277/64 , C07D413/10 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： Heterocyclic dione compounds as disclosed in the specification, compositions thereof and methods for the use thereof, for the treatment of T cell-mediated conditions such as autoimmune diseases and organ graft rejection.
摘要翻译： 本说明书，其组合物及其使用方法中所公开的杂环二酮化合物，用于治疗T细胞介导的病症如自身免疫性疾病和器官移植排斥。
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4.发明申请BENZOTHIAZOLE- AND BENZOOXAZOLE-4,7-DIONE, DERIVATIVES AND THEIR USE AS CDC25 PHOSPHATE INHIBITORS 失效苯并噻唑和苯并恶唑-4,7-二酮，衍生物及其用作CDC25磷酸盐抑制剂公开(公告)号：US20070293487A1
公开(公告)日：2007-12-20
申请号：US11849092
申请日：2007-08-31
申请人： Marie-Odile GALCERA CONTOUR , Olivier Levergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
发明人： Marie-Odile GALCERA CONTOUR , Olivier Levergne , Marie-Christine Brezak Pannetier , Gregoire Prevost
IPC分类号： A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61P35/00
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
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公开(公告)号：US20060235027A1
公开(公告)日：2006-10-19
申请号：US11410659
申请日：2006-04-25
申请人： Gregoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Francoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
发明人： Gregoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Francoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
IPC分类号： A61K31/495 , A61K31/445 , A61K31/165
CPC分类号： C07D295/26 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/445 , A61K31/495 , A61K31/63 , C07C217/84 , C07C229/36 , C07C235/66 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/37 , C07D233/84 , C07D295/135 , C07D295/192 , C07D333/22 , C07D333/34 , C07F9/12
摘要： A method of inhibiting cdc25 phosphatases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound of the formula wherein the substituents are defined as in the specification.
摘要翻译： 一种抑制温血动物中的cdc25磷酸酶的方法，其包括向有需要的温血动物施用有效量的下式的化合物，其中取代基如说明书中所定义。
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6.发明授权Benzothiazole-and benzoxazole-4, 7-dione derivatives and their use as dcd25 phosphatase inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮衍生物及其作为dcd25磷酸酶抑制剂的用途公开(公告)号：US07279467B2
公开(公告)日：2007-10-09
申请号：US10500411
申请日：2002-12-24
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物
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公开(公告)号：US20060154933A1
公开(公告)日：2006-07-13
申请号：US11350692
申请日：2006-02-09
申请人： Gregoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Francoise Gramatica , Bernard Ducommun , Christophe Lanco
发明人： Gregoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Francoise Gramatica , Bernard Ducommun , Christophe Lanco
IPC分类号： A61K31/496
CPC分类号： C07D295/26 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/445 , A61K31/495 , A61K31/63 , C07C217/84 , C07C229/36 , C07C235/66 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/37 , C07D233/84 , C07D295/135 , C07D295/192 , C07D333/22 , C07D333/34 , C07F9/12
摘要： A method of inhibiting cdc25 phosphatases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an effective amount of a compound of the formula wherein the substituents are defined as in the specification.
摘要翻译： 一种抑制温血动物中的cdc25磷酸酶的方法，其包括向有需要的温血动物施用有效量的下式的化合物，其中取代基如说明书中所定义。
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8.发明授权Benzothiazole- and benzooxazole-4,7-dione, derivatives and their use as cdc25 phosphate inhibitors 失效苯并噻唑和苯并恶唑-4,7-二酮，它们作为cdc25磷酸盐抑制剂的用途公开(公告)号：US07495021B2
公开(公告)日：2009-02-24
申请号：US11849092
申请日：2007-08-31
申请人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
发明人： Marie-Odile Galcera Contour , Olivier Lavergne , Marie-Christine Brezak Pannetier , Grégoire Prevost
IPC分类号： A61K31/428 , C07D277/64 , C07D277/66
CPC分类号： C07D263/56 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C07D231/12 , C07D233/56 , C07D249/08 , C07D263/57 , C07D277/64 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The invention concerns the use as cdc25 phosphatase inhibitors, in particular cdc25-C phosphatase, and CD45 phosphatase, of compounds of general formula (I), wherein: W represents O or S. In accordance with the invention, the compounds of general formula (I) can in particular be used for preparing a medicine for cancer treatment.
摘要翻译： 本发明涉及作为通式（I）化合物的cdc25磷酸酶抑制剂，特别是cdc25-C磷酸酶和CD45磷酸酶的用途，其中：W代表O或S.根据本发明，通式（ I）特别可用于制备用于癌症治疗的药物。
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公开(公告)号：US07196084B2
公开(公告)日：2007-03-27
申请号：US10343171
申请日：2001-07-26
申请人： Grégoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Françoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
发明人： Grégoire Prevost , Marie-Christine Brezak Pannetier , Marie-Odile Galcera Contour , Christophe Thurieau , Françoise Goubin Gramatica , Bernard Ducommun , Christophe Lanco
IPC分类号： A01N43/58 , A61K31/50 , C07D237/02 , C07D295/00
CPC分类号： C07D295/26 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/381 , A61K31/445 , A61K31/495 , A61K31/63 , C07C217/84 , C07C229/36 , C07C235/66 , C07C311/08 , C07C311/13 , C07C311/21 , C07C311/29 , C07C311/37 , C07D233/84 , C07D295/135 , C07D295/192 , C07D333/22 , C07D333/34 , C07F9/12
摘要： The invention concerns novel cdc25 phosphatase inhibitors, and in particular cdc25-C, which correspond to the general formula (I) wherein: A represents a carbocyclic aryl radical optionally substituted 1 to 3 times by one or more radicals independently selected among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical or R1 and R2 form together with the nitrogen atom a heterocycle of 4 to 7 members comprising 1 to 2 heteroatoms, the members required to complete the heterocycle being selected independently among the CR3R4—, —O—, —S and NR5-radicals, R3 and R4 representing independently each time they are involved a hydrogen atom or an alkyl, hydroxy, alkoxy, amino, alkylamino or dialkylamino radical, and R5 representing independently each time it is involved a hydrogen atom or an alkyl radical, or A represents a phenyl radical substituted by a phenyl radical optionally substituted 1 to 3 times by one or more radicals selected independently among a halogen atom and an alkyl, hydroxy, alkoxy, alkylthio or NR1R2 radical wherein R1 and R2 represent a hydrogen atom or an alkyl radical; B represents a —(CH2)i—(CO)— or —NH—CO—(CH2)n or —(CH2)p and i and n being integers from 0 to 2 and p being an integer from 0 to 1; W represents a hydrogen atom or an alkyl radical; X represents a —(CH2)q— or (CH2)j—CO—(CH2)r—, q being an integer from 1 to 4 and j and r being integers from 0 to 6; Y represents in particular a nitrophenyl, aminophenyl, alkylaminophenyl or dialkylaminophenyl radical or the radical (T)
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公开(公告)号：US20050208155A1
公开(公告)日：2005-09-22
申请号：US10864230
申请日：2004-06-09
IPC分类号： C12N9/99 , A61K20060101 , A61K6/00 , A61K31/343 , A61K31/365 , A61K36/00 , A61K36/185 , A61K36/28 , A61K127/00 , A61P31/12 , A61P33/00 , A61P33/02 , A61P33/06 , A61P35/00 , B01D11/02 , C07D493/22 , A61K35/78
CPC分类号： A61K36/28 , Y02A50/411
摘要： A method of treating proliferative diseases in warm-blooded animals comprising administering to warm-blooded animals in need thereof an amount of at least one compound selected from the group consisting of mikanolide and dihydromikanolide sufficient to treat said disease.
摘要翻译： 一种在温血动物中治疗增殖性疾病的方法，包括向有需要的温血动物施用一定量的至少一种选自足以治疗所述疾病的米卡尼定和二氢喜康内酯的化合物。
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