-
公开(公告)号：US20160104559A1
公开(公告)日：2016-04-14
申请号：US14513568
申请日：2014-10-14
申请人： Mario G. Sepulveda , Martin G. Pineda , Anthony Vranicar , Kedar V. Bhatawadekar , Minh V. Ngo , Dov Nitzan
发明人： Mario G. Sepulveda , Martin G. Pineda , Anthony Vranicar , Kedar V. Bhatawadekar , Minh V. Ngo , Dov Nitzan
CPC分类号： H01C1/034 , H01C1/1406 , H01C7/001 , H01C17/02
摘要： A method of manufacturing a surface mount device includes forming a plaque from a material, forming a plurality of conductive protrusions on a top surface and a bottom surface of the plaque, and applying a liquid encapsulant over at least a portion of the top surface and at least a portion of the bottom surface of the plaque. The liquid encapsulant is cured and when cured encapsulant has an oxygen permeability of less than about 0.4 cm3·mm/m2·atm·day. The assembly is cut to provide a plurality of components. After cutting, the top surface of each component includes at least one conductive protrusion, the bottom surface of each component includes at least one conductive protrusion, the top surface and the bottom surface of each component include the cured encapsulant, and a core of each component includes the material.
摘要翻译： 一种制造表面贴装装置的方法包括从材料形成斑块，在板的顶表面和底表面上形成多个导电突起，以及在顶表面的至少一部分上以及 斑块底面的至少一部分。 液体密封剂固化，固化后的密封剂的氧气渗透率小于约0.4 cm3·mm / m2·atm·天。 组件被切割以提供多个部件。 在切割之后，每个部件的顶表面包括至少一个导电突起，每个部件的底表面包括至少一个导电突起，每个部件的顶表面和底表面包括固化的密封剂，以及每个部件的芯部 包括材料。
-
公开(公告)号：US20160105965A1
公开(公告)日：2016-04-14
申请号：US14513552
申请日：2014-10-14
申请人： Mario G. Sepulveda , Martin G. Pineda , Anthony Vranicar , Kedar V. Bhatawadekar , Minh V. Ngo , Dov Nitzan
发明人： Mario G. Sepulveda , Martin G. Pineda , Anthony Vranicar , Kedar V. Bhatawadekar , Minh V. Ngo , Dov Nitzan
摘要： A method of manufacturing a surface mount device includes providing at least one core device and at least one lead frame. The core device is attached to the lead frame. The core device and the lead frame are encapsulated within an encapsulant. The encapsulant comprises a liquid epoxy that when cured has an oxygen permeability of less than approximately 0.4 cm3•mm/m2•atm•day.
摘要翻译： 制造表面贴装器件的方法包括提供至少一个芯片器件和至少一个引线框架。 核心设备连接到引线框架。 核心器件和引线框架封装在密封剂中。 密封剂包括液态环氧树脂，当固化时，氧气渗透率小于约0.4 cm3•mm / m2•atm•天。
-
3.发明授权Arylamine-substituted quinazolinone compounds useful as alpha 1A/B adrenergic receptor antagonists 失效可用作α1A / B肾上腺素能受体拮抗剂的芳胺取代的喹唑啉酮化合物公开(公告)号：US07244738B2
公开(公告)日：2007-07-17
申请号：US10884768
申请日：2004-07-02
申请人： Terrence Joseph Connolly , Paul Francis Keitz , Eun Kyung Lee , Jim Li , Francisco Javier Lopez-Tapia , Patrick Finbar McGarry , Chris Richard Melville , Dov Nitzan , Counde O'Yang , Fernando Padilla , Klaus Kurt Weinhardt
发明人： Terrence Joseph Connolly , Paul Francis Keitz , Eun Kyung Lee , Jim Li , Francisco Javier Lopez-Tapia , Patrick Finbar McGarry , Chris Richard Melville , Dov Nitzan , Counde O'Yang , Fernando Padilla , Klaus Kurt Weinhardt
IPC分类号： A61K31/517 , A01N43/54 , C07D239/72 , A61K31/549 , C07D417/02 , C07D285/26
CPC分类号： C07D401/12 , C07D239/90 , C07D239/95 , C07D285/24 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： Compounds represented by Formula I: which are useful as are alpha-1A/B adrenoceptor antagonists, to methods of treating conditions associated with the activity of alpha-1A/B adrenoceptors, and to methods of making said compounds, wherein Ar, Z, R, R′, R5 and R10 are as defined herein.
摘要翻译： 由式I表示的化合物：其可用作α-1A / B肾上腺素受体拮抗剂，用于治疗与α-1A / B肾上腺素受体的活性相关的病症的方法，以及制备所述化合物的方法，其中Ar，Z，R R'，R 5和R 10如本文所定义。
-
公开(公告)号：US08288552B2
公开(公告)日：2012-10-16
申请号：US12637923
申请日：2009-12-15
申请人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Dov Nitzan , Keith Adrian Murray Walker , Shu-Hai Zhao
发明人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Dov Nitzan , Keith Adrian Murray Walker , Shu-Hai Zhao
IPC分类号： C07D211/00 , A61K31/44
CPC分类号： C07D211/86 , C07D405/12
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4, R5 and Ra are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
摘要翻译： 式I化合物或其药学上可接受的盐，其中m，n，R1，R2，R3，R4，R5和Ra如本文所定义。 还公开了制备化合物和使用该化合物治疗与P2X7嘌呤能受体有关的疾病的方法。
-
公开(公告)号：US08153809B2
公开(公告)日：2012-04-10
申请号：US12637903
申请日：2009-12-15
申请人： Christine E. Brotherton-Pleiss , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Dov Nitzan , Keith Adrian Murray Walker
发明人： Christine E. Brotherton-Pleiss , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Dov Nitzan , Keith Adrian Murray Walker
IPC分类号： C07D213/62 , A61K31/44
CPC分类号： C07D211/86 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n, R1, R2, R3, R4 and R5 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.
摘要翻译： 式I化合物或其药学上可接受的盐，其中m，n，R 1，R 2，R 3，R 4和R 5如本文所定义。 还公开了制备化合物和使用该化合物治疗与P2X7嘌呤能受体有关的疾病的方法。
-
公开(公告)号：US07754759B2
公开(公告)日：2010-07-13
申请号：US11592685
申请日：2006-11-03
申请人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Lee Edwin Lowrie, Jr. , Dov Nitzan , Shu-Hai Zhao
发明人： Jacob Berger , Joan Marie Caroon , Francisco Javier Lopez-Tapia , Lee Edwin Lowrie, Jr. , Dov Nitzan , Shu-Hai Zhao
IPC分类号： A61K31/353 , C07D311/22 , C07D311/58
CPC分类号： C07D311/22 , C07D311/58 , C07D405/06
摘要： Compounds of the formula I: wherein m, n, p, X, Ar, R1, R2, R3, R4 and R5 are as defined herein. Methods of making the compounds and using the compounds for treatment of 5-HT6 receptor-mediated diseases are disclosed.
摘要翻译： 式I化合物：其中m，n，p，X，Ar，R 1，R 2，R 3，R 4和R 5如本文所定义。 公开了制备化合物和使用该化合物治疗5-HT6受体介导的疾病的方法。
-
7.发明授权Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists 失效烷氧基羰基氨基苯甲酸或烷氧基羰基氨基四唑基苯基衍生物作为IP拮抗剂公开(公告)号：US06903086B2
公开(公告)日：2005-06-07
申请号：US10087034
申请日：2002-03-01
IPC分类号： A61K31/27 , A61K31/343 , A61K31/381 , A61K31/41 , A61K31/443 , A61K31/497 , A61K31/501 , A61K31/506 , A61P7/10 , A61P9/00 , A61P11/00 , A61P11/06 , A61P13/02 , A61P25/04 , A61P29/00 , A61P37/08 , A61P43/00 , C07C271/26 , C07C271/28 , C07D307/80 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , A61K31/33 , A61K31/34 , C07D209/00 , C07D257/04 , C07D307/00
CPC分类号： C07D405/04 , C07C271/28 , C07D307/80 , C07D405/12 , C07D409/04 , C07D409/12
摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein G1 is selected from the group consisting of a, b1 and b2, and A and G2 are as defined in the specification; or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中G 1选自a，b 1和b 2， SUP> 2 ，以及A和G 2如说明书中所定义; 或其药学上可接受的盐或溶剂化物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。
-
8.发明授权Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists 失效作为IP拮抗剂的烷氧基羰基氨基杂芳基羧酸衍生物公开(公告)号：US06569860B2
公开(公告)日：2003-05-27
申请号：US10086615
申请日：2002-03-01
IPC分类号： C07D4010
CPC分类号： C07D405/12
摘要： This invention relates to compounds which are IP receptor antagonists and which are represented by Formula (I): wherein G2 is a heteroaryl group containing one or two nitrogen atoms substituted with a carboxylic acid group, said heteroaryl ring containing one or two nitrogen atoms, and G1 is as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and methods of preparation thereof.
摘要翻译： 本发明涉及作为IP受体拮抗剂并由式（I）表示的化合物：其中G 2是含有一个或两个被羧酸基团取代的氮原子的杂芳基，所述杂芳基环含有一个或两个氮原子，和 G1如规范中所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。
-
公开(公告)号：US07776910B2
公开(公告)日：2010-08-17
申请号：US11983347
申请日：2007-11-08
IPC分类号： A61K31/40 , A61K31/404 , C07D207/04 , C07D403/12
CPC分类号： C07D207/36 , C07D207/08 , C07D207/48 , C07D403/12
摘要： Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.
摘要翻译： 式I化合物：其中m，n，Ar，R 1和R 2如本文所定义。 公开了制备化合物和使用该化合物的方法。
-
公开(公告)号：US20080167361A1
公开(公告)日：2008-07-10
申请号：US11983347
申请日：2007-11-08
IPC分类号： A61K31/416 , C07D207/04 , A61K31/40 , A61P25/28 , C07D403/12 , A61K31/404
CPC分类号： C07D207/36 , C07D207/08 , C07D207/48 , C07D403/12
摘要： Compounds of the formula I: wherein m, n, Ar, R1 and R2 are as defined herein. Methods of making the compounds and using the compounds are disclosed.
摘要翻译： 式I化合物：其中m，n，Ar，R 1和R 2如本文所定义。 公开了制备化合物和使用该化合物的方法。
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.039 秒)
