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公开(公告)号:US20070074297A1
公开(公告)日:2007-03-29
申请号:US11511576
申请日:2006-08-29
申请人: Marius Hoener , Lothar Lindemann , Aiko Meyer , Meike Pauly-Evers
发明人: Marius Hoener , Lothar Lindemann , Aiko Meyer , Meike Pauly-Evers
IPC分类号: A01K67/027 , C12Q1/00 , G01N1/30
CPC分类号: C07K14/723 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0356 , A01K2267/0393 , C12N15/8509 , G01N1/30
摘要: The present invention relates to a vector construct comprising genomic sequences homologous to upstream and downstream regions flanking the single coding exon of the TAAR1 gene, one or more selection marker genes and optionally a reporter gene and the use thereof. The present invention further provides TAAR1 knock-out animals and the use thereof.
摘要翻译: 本发明涉及包含与TAAR1基因的单个编码外显子侧翼的上游和下游区域同源的基因组序列,一个或多个选择标记基因和任选的报道基因的载体构建体及其用途。 本发明还提供了TAAR1敲除动物及其用途。