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公开(公告)号：US20060070136A1
公开(公告)日：2006-03-30
申请号：US11274814
申请日：2005-11-15
IPC分类号： A01K67/027 , C12N15/63
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , C12N2830/008
摘要： The present invention provides genetic constructs and methods for producing transgenic non-human animals comprising within their genome transgenic DNA encoding GLYT1. These transgenic animals could be further used to generate transgenic animals which produce more active GLYT1. Also provided are transgenic animals producing more GLYT1 protein, as well as the methods of producing same. The invention also relates to the use of these animals as a model for analyzing the effects of depressing synaptic NMDA receptor function and studying the ability of compounds to reduce symptoms of psychotic behavior.
摘要翻译： 本发明提供用于产生转基因非人动物的遗传构建体和方法，其在其基因组中包含编码GLYT1的转基因DNA。 这些转基因动物可以进一步用于产生产生更活性的GLYT1的转基因动物。 还提供了产生更多GLYT1蛋白质的转基因动物以及其生产方法。 本发明还涉及这些动物作为分析抑制突触NMDA受体功能的作用并研究化合物降低精神病性症状的能力的模型。
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公开(公告)号：US20050026292A1
公开(公告)日：2005-02-03
申请号：US10861302
申请日：2004-06-04
IPC分类号： A01K67/027 , C07K14/47 , C12N5/10 , C12N15/09 , C12N15/85 , C12Q1/02 , G01N33/15 , G01N33/50 , C12N1/20 , C12N15/74
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2217/20 , A01K2227/105 , A01K2267/03 , C07K14/47 , C12N2517/02 , C12N2800/30
摘要： Vector constructs and methods for producing non-human transgenic animals comprising within their genome a conditional targeted mutation within the glyt1 gene are provided. These animals can be utilized as a tool for assessing GLYT1 function as well as a model for studying the effects of enhancing synaptic NMDA receptor function. In addition, these animals can be utilized for studying the susceptibility to compounds inducing psychotic behavior.
摘要翻译： 提供用于产生非人转基因动物的载体构建体和方法，其在其基因组内包含glyt1基因内的条件靶向突变。 这些动物可用作评估GLYT1功能的工具，以及研究增强突触NMDA受体功能的作用的模型。 此外，这些动物可用于研究诱导精神病性行为的化合物的易感性。
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公开(公告)号：US20070074297A1
公开(公告)日：2007-03-29
申请号：US11511576
申请日：2006-08-29
申请人： Marius Hoener , Lothar Lindemann , Aiko Meyer , Meike Pauly-Evers
发明人： Marius Hoener , Lothar Lindemann , Aiko Meyer , Meike Pauly-Evers
IPC分类号： A01K67/027 , C12Q1/00 , G01N1/30
CPC分类号： C07K14/723 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2227/703 , A01K2267/0356 , A01K2267/0393 , C12N15/8509 , G01N1/30
摘要： The present invention relates to a vector construct comprising genomic sequences homologous to upstream and downstream regions flanking the single coding exon of the TAAR1 gene, one or more selection marker genes and optionally a reporter gene and the use thereof. The present invention further provides TAAR1 knock-out animals and the use thereof.
摘要翻译： 本发明涉及包含与TAAR1基因的单个编码外显子侧翼的上游和下游区域同源的基因组序列，一个或多个选择标记基因和任选的报道基因的载体构建体及其用途。 本发明还提供了TAAR1敲除动物及其用途。
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公开(公告)号：US20050210540A1
公开(公告)日：2005-09-22
申请号：US11080962
申请日：2005-03-15
IPC分类号： A01K67/027 , C07K14/47 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/85 , C12Q1/00 , C12Q1/02 , G01N33/15 , G01N33/50
CPC分类号： C07K14/47 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0356 , C12N15/8509 , C12N2830/008
摘要： The present invention provides genetic constructs and methods for producing transgenic non-human animals comprising within their genome transgenic DNA encoding GLYT1. These transgenic animals could be further used to generate transgenic animals which produce more active GLYT1. Also provided are transgenic animals producing more GLYT1 protein, as well as the methods of producing same. The invention also relates to the use of these animals as a model for analyzing the effects of depressing synaptic NMDA receptor function and studying the ability of compounds to reduce symptoms of psychotic behavior.
摘要翻译： 本发明提供用于产生转基因非人动物的遗传构建体和方法，其在其基因组中包含编码GLYT1的转基因DNA。 这些转基因动物可以进一步用于产生产生更活性的GLYT1的转基因动物。 还提供了产生更多GLYT1蛋白质的转基因动物以及其生产方法。 本发明还涉及这些动物作为分析抑制突触NMDA受体功能的作用并研究化合物降低精神病性症状的能力的模型。
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