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公开(公告)号：US20060079466A1
公开(公告)日：2006-04-13
申请号：US11229007
申请日：2005-09-15
申请人： Mark Abel , Roman Szweda , Daniel Trepaier , Randall Yatscoff , Robert Foster
发明人： Mark Abel , Roman Szweda , Daniel Trepaier , Randall Yatscoff , Robert Foster
IPC分类号： A61K31/7052 , C07H17/02
CPC分类号： A61K31/7052 , A61K31/436 , C07D498/18 , C07H15/04 , C07H19/01
摘要： This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.
摘要翻译： 本发明提供了具有通过连接体连接的具有增强的药代动力学和/或药效学特征的雷帕霉素碳水化合物衍生物的特异性单糖，寡糖，假糖或其衍生物的修饰的雷帕霉素。 例如，雷帕霉素碳水化合物衍生物的施用导致药代动力学特征改变和毒性降低。 因此，本发明提供具有与其同类其他药物不同的特征的化合物，例如雷帕霉素。
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公开(公告)号：US07160867B2
公开(公告)日：2007-01-09
申请号：US10845747
申请日：2004-05-13
IPC分类号： A61K31/70 , A61K31/44 , C07H15/00 , C07D487/00 , A61F13/00
CPC分类号： A61K31/7052 , A61K31/436 , C07D498/18 , C07H15/04 , C07H19/01
摘要： This invention provides modified rapamycins that have specific monosaccharide(s), oligosaccharide(s), pseudosugar(s) or derivatives thereof attached through a linker to create rapamycin carbohydrate derivatives having enhanced pharmacokinetic and/or pharmacodynamic profiles. For example, administration of the rapamycin carbohydrate derivative results in altered pharmacokinetic profiles and reduced toxicities. Thus, the present invention provides compounds with characteristics that are distinct from other drugs in its class such as rapamycin.
摘要翻译： 本发明提供了具有通过连接体连接的具有增强的药代动力学和/或药效学特征的雷帕霉素碳水化合物衍生物的特异性单糖，寡糖，假糖或其衍生物的修饰的雷帕霉素。 例如，雷帕霉素碳水化合物衍生物的施用导致药代动力学特征改变和毒性降低。 因此，本发明提供具有与其同类其他药物不同的特征的化合物，例如雷帕霉素。
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3.发明授权Modified .alpha.-D-Glc.rho.-(1-2)-.alpha.-D-Glc.rho.-(1-3)-.alpha.-D-Glc.rho.-ana logues 失效修饰的α-D-Glc rho-（1-2）-α-D-Glc rho-（1-3）-α-D-Glc rho -analogues
公开(公告)号：US5929037A
公开(公告)日：1999-07-27
申请号：US485057
申请日：1995-06-07
申请人： Om Srivastava , Roman Szweda
发明人： Om Srivastava , Roman Szweda
摘要： Disclosed is the trisaccharide .alpha.-D-Glcp-(1-2)-.alpha.-D-Glcp-(1-3)-.alpha.-D-Glcp and compounds related thereto as well as pharmaceutical compositions thereof.
摘要翻译： 公开了三糖α-D-Glcp-（1-2）-β-D-Glcp-（1-3）-β-D-Glcp及其相关化合物及其药物组合物。
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4.发明授权Oligosaccharide glycosides having mammalian immunosuppresive and tolerogenic properties 失效具有哺乳动物免疫抑制和耐受性的寡糖糖苷
公开(公告)号：US5874411A
公开(公告)日：1999-02-23
申请号：US754097
申请日：1996-11-13
申请人： Om P. Srivastava , Geeta Srivastava , Roman Szweda , David R. Bundle , Ole Hindsgaul , H. Rizk Hanna , Kevin Holme , Frank W. Barresi , Minghui Du
发明人： Om P. Srivastava , Geeta Srivastava , Roman Szweda , David R. Bundle , Ole Hindsgaul , H. Rizk Hanna , Kevin Holme , Frank W. Barresi , Minghui Du
摘要： Disclosed are novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties, pharmaceutical compositions containing such oligosaccharide glycosides and to methods of using such oligosaccharide glycosides to modulate cell-mediated immune responses in a mammal.
摘要翻译： 公开了具有哺乳动物免疫抑制和耐受性的新型寡糖糖苷，含有这种寡糖糖苷的药物组合物以及使用这种寡糖糖苷来调节哺乳动物细胞介导的免疫应答的方法。
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公开(公告)号：US5877157A
公开(公告)日：1999-03-02
申请号：US813493
申请日：1997-03-07
申请人： Om Srivastava , Roman Szweda , Ulrike Spohr
发明人： Om Srivastava , Roman Szweda , Ulrike Spohr
摘要： Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.
摘要翻译： 公开了包含这种类似物的曲酸和糖组合物的新型类似物。
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6.发明授权
公开(公告)号：US5571796A
公开(公告)日：1996-11-05
申请号：US466621
申请日：1995-06-06
CPC分类号： A61K31/7008 , C07H15/18
摘要： The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.
摘要翻译： 本发明涉及由于通过施用维甲胺相关的二糖化合物和该方法中使用的药物组合物而导致由于抗原暴露（攻击）而减少由哺乳动物的次级免疫应答引起的炎症程度的方法。
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公开(公告)号：US5814616A
公开(公告)日：1998-09-29
申请号：US744203
申请日：1996-11-05
CPC分类号： A61K31/7008 , C07H15/18
摘要： The present invention is directed to methods of reducing the degree of inflammation arising from a secondary immune response in a mammal due to antigen exposure (challenge) by the administration of valienamine-related disaccharide compounds and the pharmaceutical compositions employed in the method.
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公开(公告)号：US5633233A
公开(公告)日：1997-05-27
申请号：US481645
申请日：1995-06-07
申请人： Om Srivastava , Roman Szweda , Ulrike Spohr
发明人： Om Srivastava , Roman Szweda , Ulrike Spohr
摘要： Disclosed are novel analogues of kojibiose and pharmaceutical compositions comprising such analogues.
摘要翻译： 公开了包含这种类似物的曲酸和糖组合物的新型类似物。
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