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35 条记录 (耗时 0.026 秒)

    Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids
    2.
    发明授权
    Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids 失效
    N-乙酰神经氨酸的4,7-二烷基显色糖苷的合成

    公开(公告)号：US06303764B1

    公开(公告)日：2001-10-16

    申请号：US09406024

    申请日：1999-09-24

    申请人： Om Srivastava ,  Geeta Srivastava ,  Minghui Du ,  Ole Hindsgaul ,  David R. Bundle ,  Avraham Liav

    发明人： Om Srivastava ,  Geeta Srivastava ,  Minghui Du ,  Ole Hindsgaul ,  David R. Bundle ,  Avraham Liav

    IPC分类号： G07G300

    CPC分类号： C07K14/005 ,  C12N2760/16122 ,  C12N2760/16222 ,  C12P19/14

    摘要： The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.

    摘要翻译： 本发明提供一种制备用于检测A型和B型流感病毒的N-乙酰神经氨酸（Neu5Ac）的4,7-二-O-烷基显色酮面的改进方法。酮是一种由 神经氨酸酶对流感病毒，但不是在其他病毒或细菌上发现的神经氨酸酶。 该合成是有效的，并为商业开发提供大量的酮基。 该合成包括通过包括使衍生物与包含烷基卤的组合物接触以形成4,7-二-O-的方法使得Neu5Ac的被保护的烷基酯烷基酮酮衍生物的4-和7-羟基烷基化的步骤 烷基保护的烷基酯Neu5Ac的烷基酮基衍生物。 合成交替地包括通过形成Neu5Ac的8,9-环氧化物保护的烷基酯烷基酮内酯衍生物来保护Neu5Ac的烷基酯烷基酮酮衍生物的8-和9-羟基。

    Library of glyco-peptides useful for identification of cell adhesion inhibitors
    4.
    发明授权
    Library of glyco-peptides useful for identification of cell adhesion inhibitors 失效
    用于鉴定细胞粘附抑制剂的糖肽图书馆

    公开(公告)号：US5795958A

    公开(公告)日：1998-08-18

    申请号：US664303

    申请日：1996-06-10

    申请人： Narasinga Rao ,  Morten Meldal ,  Klaus Bock ,  Ole Hindsgaul

    发明人： Narasinga Rao ,  Morten Meldal ,  Klaus Bock ,  Ole Hindsgaul

    IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K38/22 ,  A61P5/00 ,  A61P31/04 ,  A61P35/00 ,  C07K1/04 ,  C07K9/00 ,  C07K16/18 ,  A61K38/06

    CPC分类号： C07K9/001 ,  C07K1/047 ,  A61K38/00

    摘要： Glycopeptides having the following structure are described: ##STR1## wherein: X.sub.1 is hydrogen, an acetyl group, an acyl group or amino acid; R is .alpha.-L-fucose, .alpha.-D-fucose, .beta.-L-fucose or .beta.-D-fucose, wherein R is O-glucosidically linked to A.sub.1 ; A.sub.1 is serine, threonine, tyrosine, hydroxyproline, asparagine, glutamine, homeoserine and hydroxylysine; A.sub.2 is a glycine, an L-amino acid, a D-amino acid or a modified amino acid; A.sub.3 is L or D aspartic acid, glycine or glutamic acid; and X.sub.2 is a hydroxyl, an amine or an amino acid.

    摘要翻译： 描述了具有以下结构的糖肽：其中：X 1是氢，乙酰基，酰基或氨基酸; R是α-L-岩藻糖，α-D-岩藻糖，β-L-岩藻糖或β-D-岩藻糖，其中R是与α-糖苷键连接的; A1是丝氨酸，苏氨酸，酪氨酸，羟脯氨酸，天冬酰胺，谷氨酰胺，高丝氨酸和羟赖氨酸; A2是甘氨酸，L-氨基酸，D-氨基酸或修饰的氨基酸; A3是L或D天冬氨酸，甘氨酸或谷氨酸; X2是羟基，胺或氨基酸。

    Inhibitors for alpha-L-fucosyl transferase
    5.
    发明授权
    Inhibitors for alpha-L-fucosyl transferase 失效
    α-L-岩藻糖基转移酶的抑制剂

    公开(公告)号：US5206356A

    公开(公告)日：1993-04-27

    申请号：US730227

    申请日：1991-07-15

    申请人： James M. Pierce ,  Ole Hindsgaul

    发明人： James M. Pierce ,  Ole Hindsgaul

    IPC分类号： A61K31/70 ,  C07H15/04 ,  C07H15/18

    CPC分类号： C07H15/18 ,  A61K31/70 ,  C07H15/04

    摘要： Synthetic glycosaminosyl transferase-V acceptors and inhibitors are disclosed. Minimal trisaccharide inhibitors and acceptors specific for GnT-V, which is associated with the ability of cells to metastasize are useful, in diagnosis and treatment of conditions characterized by metastatic cells.

    摘要翻译： 公开了合成的糖基糖基转移酶-V受体和抑制剂。 与细胞转移能力相关的GnT-V特异性的最小三糖抑制剂和受体可用于诊断和治疗以转移细胞为特征的病症。

    SOLID-PHASE DETECTION OF TERMINAL MONOSACCHARIDES CLEAVED FROM GLYCOSYLATED SUBSTRATES
    6.
    发明申请
    SOLID-PHASE DETECTION OF TERMINAL MONOSACCHARIDES CLEAVED FROM GLYCOSYLATED SUBSTRATES 失效
    从胶体基质中清除终端单糖的固相检测

    公开(公告)号：US20100047828A1

    公开(公告)日：2010-02-25

    申请号：US12373331

    申请日：2007-07-10

    申请人： Mads Detlef Sorensen ,  Rita Martins ,  Ole Hindsgaul

    发明人： Mads Detlef Sorensen ,  Rita Martins ,  Ole Hindsgaul

    IPC分类号： G01N33/58 ,  C07H1/00

    CPC分类号： C12Q1/34 ,  G01N33/543 ,  G01N33/58 ,  Y10T436/143333 ,  Y10T436/144444

    摘要： The present invention relates to a novel method for analysing carbohydrates. The invention is in particular useful in detecting a terminal monosaccharide which may be released from a glycosylated substrate for example using an exoglucosidase. After relase from the glycosylated substrate the terminal monosaccharide may be captured on a solid support, incubated with a boronate detection agent and detected by aid of the boronate detection agent. The methods of the invention are useful for a variety of purposes including sequencing of carbohydrates, wherein exoglycosidases with predetermined specificity are employed for the release.

    摘要翻译： 本发明涉及一种分析碳水化合物的新方法。 本发明特别可用于检测可以例如使用外切葡糖苷酶从糖基底物释放的末端单糖。 在从糖基化的底物上脱除后，末端单糖可以捕获在固体支持物上，与硼酸盐检测剂一起孵育并通过硼酸盐检测剂的检测。 本发明的方法可用于多种目的，包括碳水化合物的测序，其中使用具有预定特异性的exoglycosidases用于释放。