公开(公告)号：US06991936B2

公开(公告)日：2006-01-31

申请号：US10364012

申请日：2003-02-10

申请人： Mark C. Fishman ,  Tao P. Zhong

发明人： Mark C. Fishman ,  Tao P. Zhong

IPC分类号： C12N1/00 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47

摘要： The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.

公开(公告)号：US06558932B1

公开(公告)日：2003-05-06

申请号：US09705534

申请日：2000-11-03

申请人： Mark C. Fishman ,  Tao P. Zhong

发明人： Mark C. Fishman ,  Tao P. Zhong

IPC分类号： C12N900

CPC分类号： C07K16/18 ,  A61K38/00 ,  C07K14/47

摘要： The invention provides a novel gene, gridlock, and its encoded protein. gridlock plays a role in vascular development and modeling, and a mutation in gridlock has been associated with an aortic arch disease, coarctation. Thus, gridlock nucleic acid molecules and polypeptides can be used in methods of diagnosing, treating, and preventing gridlock-related diseases and conditions, such as aortic arch diseases.