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3 条记录 (耗时 0.038 秒)

    Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents
    2.
    发明授权
    Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A.sub.2 receptor antagonist and pharmaceutical compositions containing such solvents 失效
    使用血栓素A2受体拮抗剂抑制含有蓖麻油酸或蓖麻油或其衍生物的溶剂的副作用的方法和含有这些溶剂的药物组合物

    公开(公告)号：US5462726A

    公开(公告)日：1995-10-31

    申请号：US168348

    申请日：1993-12-17

    申请人： Nicholas J. Lodge

    发明人： Nicholas J. Lodge

    IPC分类号： A61K9/00 ,  A61K31/422 ,  A61K31/64 ,  A61K38/13 ,  A61K47/44 ,  A61K49/00

    CPC分类号： A61K9/0019 ,  A61K31/422 ,  A61K31/64 ,  A61K38/13 ,  A61K47/44 ,  Y10S514/922

    摘要： A method is provided for inhibiting or preventing toxicity and other unwanted effects (a) caused by solvents for pharmaceuticals which solvents contain castor oil or ricinoleic acid or derivatives thereof, such as Cremophor, or (b) caused by a drug, such as cyclosporine A, dissolved or suspended in solvents such as ricinoleic acid or castor oil or derivative thereof, employing a thromboxane A.sub.2 receptor antagonist. Solvent compositions containing ricinoleic acid or castor oil or derivatives thereof and a thromboxane A.sub.2 receptor antagonist, and pharmaceutical compositions including a drug, solvent containing ricinoleic acid or castor oil or derivative thereof, and a thromboxane A.sub.2 receptor antagonist are also provided.

    摘要翻译： 提供了一种用于抑制或预防毒性和其他不希望的影响的方法（a）由溶剂包含蓖麻油或蓖麻油酸或其衍生物（例如Cremophor）或（b）由药物如环孢菌素A引起的药物的溶剂引起的 ，溶解或悬浮于溶剂如蓖麻油酸或蓖麻油或其衍生物中，使用血栓素A2受体拮抗剂。 还提供了含有蓖麻油酸或蓖麻油或其衍生物和血栓烷A2受体拮抗剂的溶剂组合物，以及包含药物，含蓖麻油或蓖麻油或其衍生物的溶剂的药物组合物和血栓烷A2受体拮抗剂。

    Thiophenyl triazol-3-one derivatives as smooth muscle relaxants
    3.
    发明授权
    Thiophenyl triazol-3-one derivatives as smooth muscle relaxants 失效
    噻吩三唑-3-酮衍生物作为平滑肌松弛剂

    公开(公告)号：US06613786B2

    公开(公告)日：2003-09-02

    申请号：US10266373

    申请日：2002-10-08

    申请人： Piyasena Hewawasam ,  John E. Starrett ,  Dalton King ,  Li-Quang Sun ,  Nicholas J. Lodge

    发明人： Piyasena Hewawasam ,  John E. Starrett ,  Dalton King ,  Li-Quang Sun ,  Nicholas J. Lodge

    IPC分类号： A61K314196

    CPC分类号： C07D409/04

    摘要： The present invention provides novel [1,2,4]triazole-3-one derivatives having the general formula (I) wherein: Q is  and R1, R2, R3, R4, R5 and R6 are as defined herein or a nontoxic pharmaceutically acceptable salt or solvate thereof which are smooth muscle relaxants and useful in treating disorders responsive to relaxation of smooth muscle such as asthma, irritable bowel syndrome, male erectile dysfunction and urinary incontinence.

    摘要翻译： 本发明提供具有通式（I）的新颖的[1,2,4]三唑-3-酮衍生物，其中：Q是且R 1，R 2，R 3，R 4，R 5和R 6如本文所定义或无毒的药学上可接受的 盐或其溶剂化物，其是平滑肌松弛剂，并且可用于治疗对平滑肌松弛有响应的疾病，例如哮喘，肠易激综合征，男性勃起功能障碍和尿失禁。