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1.发明授权Methods of screening for agents that modulate the interaction of RGS and Gαq and urinary incontinence 有权筛选调节RGS和Gαq与尿失禁相互作用的药剂的方法公开(公告)号：US07846671B2
公开(公告)日：2010-12-07
申请号：US10352843
申请日：2003-01-27
申请人： Mark Cockett , Chandra S. Ramanathan , Nicholas J. Lodge , Kevin Fitzgerald , Terry Stouch , Lisa Moore , Rachel M. Kindt , Jenny Kopczynski , Stephen Kohl Doberstein
发明人： Mark Cockett , Chandra S. Ramanathan , Nicholas J. Lodge , Kevin Fitzgerald , Terry Stouch , Lisa Moore , Rachel M. Kindt , Jenny Kopczynski , Stephen Kohl Doberstein
IPC分类号： G01N33/53
CPC分类号： G01N33/6893 , G01N2333/726 , G01N2333/916 , G01N2500/00 , G01N2800/341
摘要： The present invention provides methods that are useful for the treatment or prevention of smooth muscle disorders such as urinary incontinence and compounds that are useful in such methods.
摘要翻译： 本发明提供了可用于治疗或预防平滑肌疾病如尿失禁的方法和可用于这些方法的化合物。
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公开(公告)号：US20090068177A1
公开(公告)日：2009-03-12
申请号：US11981822
申请日：2007-10-31
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US06627746B1
公开(公告)日：2003-09-30
申请号：US09084303
申请日：1998-05-26
申请人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
发明人： Stephen Kohl Doberstein , Darren Mark Platt , Kimberly Carr Ferguson , Andrew Roy Buchman , Sheila Akiko Homburger
IPC分类号： C07H2104
CPC分类号： C07K14/43545 , A61K38/00
摘要： The present invention relates to C. elegans insulin-like genes and methods for identifying insulin-like genes. The methods provide nucleotide sequences of C. elegans insulin-like genes, amino acid sequences of their encoded proteins, and derivatives (e.g., fragments) and analogs thereof. The invention further relates to fragments (and derivatives and analogs thereof) of insulin-like proteins which comprise one or more domains of an insulin-like protein. Antibodies to an insulin-like protein, and derivatives and analogs thereof, are provided. Methods of production of an insulin-like protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Further, methods to identify the biological function of a C. elegans insulin-like gene are provided, including various methods for the functional modification (e.g., overexpression, underexpression, mutation, knock-out) of one or more genes simultaneously. Still further, methods to identify a C. elegans gene which modifies the function of, and/or functions in a downstream pathway from, an insulin-like gene are provided.
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公开(公告)号：US07662925B2
公开(公告)日：2010-02-16
申请号：US11483250
申请日：2006-07-07
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US20090142340A1
公开(公告)日：2009-06-04
申请号：US11927507
申请日：2007-10-29
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/18 , A61P43/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US20090081208A1
公开(公告)日：2009-03-26
申请号：US11981596
申请日：2007-10-31
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , A61P9/00 , A61P29/00
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , G16B5/00 , G16B15/00 , G16B30/00 , G16B35/00 , G16C20/60
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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公开(公告)号：US20080292621A1
公开(公告)日：2008-11-27
申请号：US11927463
申请日：2007-10-29
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US07317091B2
公开(公告)日：2008-01-08
申请号：US10822231
申请日：2004-03-26
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/22 , C07K16/283 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US20120230980A1
公开(公告)日：2012-09-13
申请号：US13346604
申请日：2012-01-09
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John Rudolph Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
IPC分类号： C07K16/28 , C12N15/13 , C12N5/10 , A61P37/04 , C12N1/19 , C12P21/02 , A61K39/395 , C07K17/00 , C12N1/21
CPC分类号： C07K16/283 , A61K39/395 , A61K39/3955 , A61K39/39566 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2875 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/41 , C07K2317/51 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/56 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12P21/005 , C40B30/02 , G06F19/12 , G06F19/16 , G06F19/22
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
摘要翻译： 本发明涉及优化的Fc变体，其产生方法，以及包含优化的Fc变体的抗体和Fc融合体。
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公开(公告)号：US08093357B2
公开(公告)日：2012-01-10
申请号：US11483378
申请日：2006-07-07
申请人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
发明人： Gregory Alan Lazar , Arthur J. Chirino , Wei Dang , John R. Desjarlais , Stephen Kohl Doberstein , Robert J. Hayes , Sher Bahadur Karki , Omid Vafa
CPC分类号： C07K16/283 , A61K2039/505 , C07K16/00 , C07K16/22 , C07K16/2863 , C07K16/2887 , C07K16/2893 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/32 , C07K2317/34 , C07K2317/71 , C07K2317/72 , C07K2317/732 , C07K2317/734 , C07K2317/77 , C07K2317/92
摘要： The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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