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    Method and compositions for the treatment of gastrointestinal disorders
    1.
    发明申请
    Method and compositions for the treatment of gastrointestinal disorders 有权
    用于治疗胃肠道疾病的方法和组合物

    公开(公告)号：US20060094658A1

    公开(公告)日：2006-05-04

    申请号：US11054072

    申请日：2005-02-08

    申请人： Mark Currie ,  Shalina Mahajan-Miklos ,  Li Sun ,  Caroline Kurtz

    发明人： Mark Currie ,  Shalina Mahajan-Miklos ,  Li Sun ,  Caroline Kurtz

    IPC分类号： A61K38/10 ,  C07K7/08

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/4705

    摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

    摘要翻译： 用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括 功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘 描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

    Methods and compositions for the treatment of gastrointestinal disorders
    2.
    发明申请
    Methods and compositions for the treatment of gastrointestinal disorders 审中-公开
    用于治疗胃肠道疾病的方法和组合物

    公开(公告)号：US20070010450A1

    公开(公告)日：2007-01-11

    申请号：US10868744

    申请日：2004-06-14

    申请人： Mark Currie ,  Shalina Mahajan-Miklos ,  Li Sun

    发明人： Mark Currie ,  Shalina Mahajan-Miklos ,  Li Sun

    IPC分类号： A61K38/10 ,  C07K7/08

    CPC分类号： C07K7/08 ,  A61K38/00

    摘要： Compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudoobstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders are described. The compositions feature peptides that activate the guanylate cyclase C (GC-C) receptor.

    摘要翻译： 用于治疗IBS和其他胃肠道疾病和病症的组合物和相关方法（例如，胃肠动力障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括 功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和与神经性疾病相关的便秘 描述了其它条件和病症，组合物具有激活鸟苷酸环化酶C（GC-C）受体的肽。

    Methods and compositions for the treatment of gastrointestinal disorders
    4.
    发明申请
    Methods and compositions for the treatment of gastrointestinal disorders 有权
    用于治疗胃肠道疾病的方法和组合物

    公开(公告)号：US20050020811A1

    公开(公告)日：2005-01-27

    申请号：US10796719

    申请日：2004-03-09

    申请人： Mark Currie ,  Shalina Mahajan-Miklos

    发明人： Mark Currie ,  Shalina Mahajan-Miklos

    IPC分类号： C07K7/06 ,  C07K7/08

    CPC分类号： C07K7/08 ,  C07K14/245

    摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

    摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘 肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其他病症和病症。

    Methods and compositions for the treatment of gastrointestinal disorders
    5.
    发明授权
    Methods and compositions for the treatment of gastrointestinal disorders 有权
    用于治疗胃肠道疾病的方法和组合物

    公开(公告)号：US08080526B2

    公开(公告)日：2011-12-20

    申请号：US12754138

    申请日：2010-04-05

    申请人： Mark Currie ,  Shalina Mahajan-Miklos ,  G. Todd Milne ,  Thea Norman

    发明人： Mark Currie ,  Shalina Mahajan-Miklos ,  G. Todd Milne ,  Thea Norman

    IPC分类号： A61K38/10

    CPC分类号： C07K7/08 ,  A61K38/00 ,  C07K14/245

    摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

    摘要翻译： 本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（ 包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘​​相关 与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。

    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide
    9.
    发明申请
    Treatment of CNS disorders with trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine and its formamide 有权
    用反式4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺及其甲酰胺处理CNS病症

    公开(公告)号：US20060216799A1

    公开(公告)日：2006-09-28

    申请号：US11416586

    申请日：2006-05-03

    申请人： Thomas Jerussi ,  Qun Fang ,  Mark Currie

    发明人： Thomas Jerussi ,  Qun Fang ,  Mark Currie

    IPC分类号： C12P13/00 ,  C07C211/42

    CPC分类号： C07C211/42 ,  C07B2200/07 ,  C07C2602/10 ,  C07C2602/28

    摘要： Treatment of CNS disorders with (1R,4S)-trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine; and (1S,4R)-trans 4-(3,4-dichlorophenyl)- 1,2,3,4-tetrahydro-1-napthalenamine is disclosed. A process for preparing 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine is also disclosed. The process includes the preparation of all four isomers of N-[4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]formamide, which are also useful.

    摘要翻译： 用（1R，4S） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺处理CNS病症; 和（1S，4R） - 反式-4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺。 还公开了制备4-（3,4-二氯苯基）-1,2,3,4-四氢-1-萘胺的方法。 该方法包括制备N- [4-（3,4-二氯苯基）-1,2,3,4-四氢萘-1-基]甲酰胺的全部四种异构体，它们也是有用的。

    Lead-free solder paste
    10.
    发明授权
    Lead-free solder paste 失效
    无铅锡膏

    公开(公告)号：US06592020B1

    公开(公告)日：2003-07-15

    申请号：US09981102

    申请日：2001-10-17

    申请人： Mark Currie ,  Angelo Elyassi ,  Grahame Freeman ,  Malcolm Warwick ,  Ian Wilding

    发明人： Mark Currie ,  Angelo Elyassi ,  Grahame Freeman ,  Malcolm Warwick ,  Ian Wilding

    IPC分类号： B23K3102

    CPC分类号： B23K35/025 ,  B23K35/262 ,  B23K35/3613 ,  B23K35/3615 ,  B23K35/3618 ,  H05K3/3484

    摘要： The invention relates to a lead-free solder paste comprising a solder paste flux and solder alloy particles that are substantially lead-free wherein the solder paste flux comprises resin dissolved in a solvent and also includes undissolved resin particles less than 25 &mgr;m in size homogenously dispersed therein to provide improved solder alloy powder coalescence and substrate surface wetting while maintaining appropriate solder paste rheology for use in printed circuit board assembly processes.

    摘要翻译： 本发明涉及一种无铅焊膏，其包含基本上无铅的焊锡膏和焊料合金颗粒，其中焊膏助焊剂包含溶解在溶剂中的树脂，还包括均匀分散的小于25μm的未溶解树脂颗粒 在其中提供改进的焊料合金粉末聚结和基底表面润湿，同时保持适用于印刷电路板组装工艺的焊膏流变性。