公开(公告)号：US20070123851A1

公开(公告)日：2007-05-31

申请号：US11613415

申请日：2006-12-20

申请人： Jose Alejandro ,  Mark Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday Kumar ,  William Malecki ,  Miriam Taimisto ,  Venkata Vegesna

发明人： Jose Alejandro ,  Mark Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday Kumar ,  William Malecki ,  Miriam Taimisto ,  Venkata Vegesna

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B17/2202 ,  A61B18/02 ,  A61B18/08 ,  A61B18/18 ,  A61B18/20 ,  A61B2017/00575 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1407 ,  A61B2018/143 ,  A61B2018/144 ,  A61B2018/1467 ,  A61B2090/3782 ,  A61B2090/3929

摘要： Methods and apparatus for treatment of layered tissue defects such as a patent foramen ovale provide for applying energy to tissues adjacent to the PFO with a closure device that substantially closes the PFO. Apparatus generally includes an elongate flexible member having a proximal end and a distal end and an energy transmission member deployable from the elongate flexible member. The energy transmission member applies energy to the layered tissue defect at a first position and a second position adjacent to the first position so as to substantially close the layered tissue defect along at least a portion of the defect. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating, direct heat energy, cryogenic or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗层状组织缺陷（例如卵孔卵孔专利）的方法和装置提供了使用基本上封闭PFO的闭合装置向PFO附近的组织施加能量。 设备通常包括细长的柔性构件，其具有近端和远端以及能够从细长柔性构件展开的能量传递构件。 能量传递部件在与第一位置相邻的第一位置和第二位置处向层状组织缺损施加能量，以沿着缺损的至少一部分基本上封闭层状组织缺损。 应用能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热，直接热能，低温等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20070123852A1

公开(公告)日：2007-05-31

申请号：US11613422

申请日：2006-12-20

申请人： Mark Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday Kumar ,  William Malecki ,  Miriam Taimisto

发明人： Mark Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday Kumar ,  William Malecki ,  Miriam Taimisto

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of layered tissue defects having a majority of the surfaces of the defect layers in contact generally involve use of a catheter having at least one energy transmission member at its distal end. The distal end of the apparatus also typically has a force applying member which can apply a force to the tissue defect. Often this force is a lateral force or vacuum which helps the tissue to appose itself. An exemplary method of closing a patent foramen ovale (PFO) involves positioning a closure device between layers of the PFO. Energy is then applied to the layered tissue defect with the closure device so as to substantially close the tissue defect. The energy is often monopolar or bipolar radiofrequency energy. A force may also be applied by the closure device to the layered tissue defect so as to bring the layered tissue defect together.

摘要翻译： 用于治疗具有接触缺陷层的大部分表面的层状组织缺陷的方法和装置通常涉及在其远端使用具有至少一个能量传递构件的导管。 该装置的远端通常还具有可施加力到组织缺损的施力部件。 这种力通常是侧向力或真空，有助于组织自身。 闭合卵孔卵泡（PFO）的示例性方法涉及将闭合装置定位在PFO的层之间。 然后用闭合装置将能量施加到层状组织缺陷，以便基本上封闭组织缺损。 能量通常是单极或双极射频能量。 还可以通过闭合装置将力施加到层状组织缺陷，以使层状组织缺陷在一起。

公开(公告)号：US08021362B2

公开(公告)日：2011-09-20

申请号：US11613422

申请日：2006-12-20

申请人： Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto

发明人： Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of layered tissue defects having a majority of the surfaces of the defect layers in contact generally involve use of a catheter having at least one energy transmission member at its distal end. The distal end of the apparatus also typically has a force applying member which can apply a force to the tissue defect. Often this force is a lateral force or vacuum which helps the tissue to appose itself. An exemplary method of closing a patent foramen ovale (PFO) involves positioning a closure device between layers of the PFO. Energy is then applied to the layered tissue defect with the closure device so as to substantially close the tissue defect. The energy is often monopolar or bipolar radiofrequency energy. A force may also be applied by the closure device to the layered tissue defect so as to bring the layered tissue defect together.

摘要翻译： 用于治疗具有接触缺陷层的大部分表面的层状组织缺陷的方法和装置通常涉及在其远端使用具有至少一个能量传递构件的导管。 该装置的远端通常还具有可施加力到组织缺损的施力部件。 这种力通常是侧向力或真空，有助于组织自身。 闭合卵孔卵泡（PFO）的示例性方法涉及将闭合装置定位在PFO的层之间。 然后用闭合装置将能量施加到层状组织缺陷，以便基本上封闭组织缺损。 能量通常是单极或双极射频能量。 还可以通过闭合装置将力施加到层状组织缺陷，以使层状组织缺陷在一起。

公开(公告)号：US07972330B2

公开(公告)日：2011-07-05

申请号：US11613415

申请日：2006-12-20

申请人： Jose Alejandro ,  Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto ,  Venkata Vegesna

发明人： Jose Alejandro ,  Mark E. Deem ,  Erik Engelson ,  Dominique Filloux ,  Dan Francis ,  Hanson Gifford ,  Kenneth Horne ,  Uday N. Kumar ,  William Malecki ,  Miriam H. Taimisto ,  Venkata Vegesna

IPC分类号： A61B18/14

CPC分类号： A61B18/1492 ,  A61B17/2202 ,  A61B18/02 ,  A61B18/08 ,  A61B18/18 ,  A61B18/20 ,  A61B2017/00575 ,  A61B2018/00083 ,  A61B2018/00214 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/00797 ,  A61B2018/00821 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1407 ,  A61B2018/143 ,  A61B2018/144 ,  A61B2018/1467 ,  A61B2090/3782 ,  A61B2090/3929

摘要： Methods and apparatus for treatment of layered tissue defects such as a patent foramen ovale provide for applying energy to tissues adjacent to the PFO with a closure device that substantially closes the PFO. Apparatus generally includes an elongate flexible member having a proximal end and a distal end and an energy transmission member deployable from the elongate flexible member. The energy transmission member applies energy to the layered tissue defect at a first position and a second position adjacent to the first position so as to substantially close the layered tissue defect along at least a portion of the defect. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating, direct heat energy, cryogenic or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗层状组织缺陷（例如卵孔卵孔专利）的方法和装置提供了使用基本上封闭PFO的闭合装置向PFO附近的组织施加能量。 设备通常包括细长的柔性构件，其具有近端和远端以及能够从细长柔性构件展开的能量传递构件。 能量传递部件在与第一位置相邻的第一位置和第二位置处向层状组织缺损施加能量，以沿着缺损的至少一部分基本上封闭层状组织缺损。 应用能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热，直接热能，低温等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20060027241A1

公开(公告)日：2006-02-09

申请号：US11249566

申请日：2005-10-12

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B19/00 ,  A61B18/04 ,  A61B18/18

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗卵圆孔卵泡（PFO）的方法和装置提供用导管装置向邻近PFO的组织施加能量，以基本上封闭PFO。 装置通常包括导管装置，其具有在其远端处或其近端处的至少一个能量传递构件，其被配置为向PFO组织施加能量以急剧，基本上关闭PFO。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。 导管装置的一些实施例还包括靠近远端的一个或多个组织定位构件，用于帮助使PFO组织在一起，例如PFO覆盖构件，真空施加构件等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20070299434A1

公开(公告)日：2007-12-27

申请号：US11894467

申请日：2007-08-20

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/18

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗卵圆孔卵泡（PFO）的方法和装置提供用导管装置向邻近PFO的组织施加能量，以基本上封闭PFO。 装置通常包括导管装置，其具有在其远端处或其近端处的至少一个能量传递构件，其被配置为向PFO组织施加能量以急剧，基本上关闭PFO。 施加的能量可以是单极性或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。 导管装置的一些实施例还包括靠近远端的一个或多个组织定位构件，用于帮助使PFO组织在一起，例如PFO覆盖构件，真空施加构件等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20070112347A1

公开(公告)日：2007-05-17

申请号：US11622194

申请日：2007-01-11

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/18

CPC分类号： A61B18/1492 ,  A61B18/1445 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods, devices and systems for treating patent foramen ovale (PFO) involve advancing a catheter device to a position in a heart for treating a PFO, bringing tissues adjacent the PFO at least partially together, and applying energy to the tissues to substantially close the PFO acutely. Catheter devices generally include an elongate catheter body, at least one tissue apposition member at or near the distal end for bringing the tissues together, and at least one energy transmission member at or near the distal end for applying energy to the tissues. In some embodiments, the tissue apposition member(s) also act as the energy transmission member(s). Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like.

摘要翻译： 用于治疗卵孔卵泡（PFO）的方法，装置和系统涉及将导管装置推进到心脏中的位置以治疗PFO，使与PFO相邻的组织至少部分地在一起，并且向组织施加能量以基本上封闭PFO 急剧地 导管装置通常包括细长导管主体，位于或靠近远端的至少一个组织定位构件，用于将组织带到一起，以及在远端处或附近的至少一个能量传递构件，用于向组织施加能量。 在一些实施例中，组织安置构件也用作能量传递构件。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。

公开(公告)号：US20060276846A1

公开(公告)日：2006-12-07

申请号：US11506230

申请日：2006-08-17

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61N1/00

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

公开(公告)号：US20060276779A1

公开(公告)日：2006-12-07

申请号：US11464755

申请日：2006-08-15

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/04

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monoploar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

摘要翻译： 用于治疗卵圆孔卵泡（PFO）的方法和装置提供用导管装置向邻近PFO的组织施加能量，以基本上封闭PFO。 装置通常包括导管装置，其具有在其远端处或其近端处的至少一个能量传递构件，其被配置为向PFO组织施加能量以急剧，基本上关闭PFO。 应用能量可以是单极或双极射频能量或任何其它合适的能量，例如激光，微波，超声波，电阻加热等。 导管装置的一些实施例还包括靠近远端的一个或多个组织定位构件，用于帮助使PFO组织在一起，例如PFO覆盖构件，真空施加构件等。 通过基于本发明的基于能量的方法的PFO闭合可以有助于预防中风，治疗偏头痛，并且可能治疗或预防其它医疗状况。

公开(公告)号：US20060241582A1

公开(公告)日：2006-10-26

申请号：US11472923

申请日：2006-06-21

申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark Deem ,  Hanson Gifford ,  Jose Alejandro

IPC分类号： A61B18/14

CPC分类号： A61B17/0057 ,  A61B17/3439 ,  A61B18/1445 ,  A61B18/1492 ,  A61B2017/00575 ,  A61B2017/00867 ,  A61B2017/306 ,  A61B2017/3445 ,  A61B2018/00214 ,  A61B2018/00261 ,  A61B2018/00285 ,  A61B2018/00291 ,  A61B2018/00351 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00702 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00898 ,  A61B2018/1472 ,  A61B2090/3614 ,  C08L2201/12

摘要： Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device further include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.