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公开(公告)号：US06228871B1
公开(公告)日：2001-05-08
申请号：US09343652
申请日：1999-06-29
申请人： Mark E. Fraley , Randall W. Hungate , William F. Hoffman , William R. Huckle , Richard L. Kendall , Kenneth A. Thomas, Jr.
发明人： Mark E. Fraley , Randall W. Hungate , William F. Hoffman , William R. Huckle , Richard L. Kendall , Kenneth A. Thomas, Jr.
IPC分类号： C07D40102
CPC分类号： C07D409/04 , C07D263/48 , C07D413/04 , C07D413/14
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases and conditions such as angiogenenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译： 本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫性疾病的方法 哺乳动物。
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公开(公告)号：US06380203B1
公开(公告)日：2002-04-30
申请号：US09424132
申请日：1999-11-18
申请人： Mark T. Bilodeau , Mark E. Fraley , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino
发明人： Mark T. Bilodeau , Mark E. Fraley , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino
IPC分类号： A61K31505
CPC分类号： C07D487/04
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases/conditions such as angiogenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译： 本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病/病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫疾病的方法 哺乳动物。
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公开(公告)号：US06235741B1
公开(公告)日：2001-05-22
申请号：US09086152
申请日：1998-05-28
申请人： Mark T. Bilodeau , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino , Mark E. Fraley
发明人： Mark T. Bilodeau , Randall W. Hungate , Richard L. Kendall , Ruth Rutledge , Kenneth A. Thomas, Jr. , Robert Rubino , Mark E. Fraley
IPC分类号： A61K31505
CPC分类号： C07D487/04
摘要： The present invention relates to compounds which inhibit tyrosine kinase enzymes, compositions which contain tyrosine kinase inhibiting compounds and methods of using tyrosine kinase inhibitors to treat tyrosine kinase-dependent diseases/conditions such as angiogenenesis, cancer, atherosclerosis, diabetic retinopathy or autoimmune diseases, in mammals.
摘要翻译： 本发明涉及抑制酪氨酸激酶的化合物，含有酪氨酸激酶抑制化合物的组合物和使用酪氨酸激酶抑制剂治疗酪氨酸激酶依赖性疾病/病症如血管生成，癌症，动脉粥样硬化，糖尿病性视网膜病变或自身免疫疾病的方法 哺乳动物。
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公开(公告)号：US06794393B1
公开(公告)日：2004-09-21
申请号：US10110872
申请日：2002-04-18
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： C07D40114
CPC分类号： C07D401/14 , A61K31/495 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US06306874B1
公开(公告)日：2001-10-23
申请号：US09690598
申请日：2000-10-17
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： A01N4342
CPC分类号： C07D413/14 , A61K31/495 , A61K45/06 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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公开(公告)号：US20080274107A1
公开(公告)日：2008-11-06
申请号：US12148649
申请日：2008-04-21
申请人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
发明人： Mark E. Fraley , Kenneth L. Arrington , Mark T. Bilodeau , George D. Hartman , William F. Hoffman , Yuntae Kim , Randall W. Hungate
IPC分类号： A61K39/395 , C07D215/20 , A61K31/337 , A61K31/445 , A61K31/47 , A61P43/00
CPC分类号： C07D401/14 , A61K31/495 , A61K45/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , A61K2300/00
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法 ，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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公开(公告)号：US06544988B1
公开(公告)日：2003-04-08
申请号：US09914985
申请日：2001-09-06
IPC分类号： C07D48704
CPC分类号： C07D487/04 , A61K31/519 , A61K31/535 , A61K41/0038 , A61K45/06
摘要： The present invention relates to pyrazolo-pyrimidinyl compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的吡唑并嘧啶基化合物，其含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤的方法 生长，动脉粥样硬化，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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公开(公告)号：US5872138A
公开(公告)日：1999-02-16
申请号：US926606
申请日：1997-09-10
申请人： Adel M. Naylor-Olsen , Gerald S. Ponticello , Joseph P. Vacca , Randall W. Hungate , Craig Coburn , Brian T. Phillips , S. D. Lewis , Mark E. Fraley
发明人： Adel M. Naylor-Olsen , Gerald S. Ponticello , Joseph P. Vacca , Randall W. Hungate , Craig Coburn , Brian T. Phillips , S. D. Lewis , Mark E. Fraley
IPC分类号： C07C257/18 , C07D213/73 , C07D213/74 , C07D295/26 , C07D405/12 , A61K31/44 , C07D213/72
CPC分类号： C07D213/73 , C07C257/18 , C07D213/74 , C07D295/26 , C07D405/12
摘要： A compound which inhibits human thrombin and which has the general structure ##STR1##
摘要翻译： 抑制人凝血酶的化合物，其具有
等一般结构 -
公开(公告)号：US06479512B1
公开(公告)日：2002-11-12
申请号：US09690602
申请日：2000-10-17
IPC分类号： A61K3147
CPC分类号： C07D401/04 , C07D401/14
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
摘要翻译： 本发明涉及抑制，调节和/或调节酪氨酸激酶信号转导的化合物，含有这些化合物的组合物及其用于治疗酪氨酸激酶依赖性疾病和病症如血管生成，癌症，肿瘤生长，动脉粥样硬化的方法 ，年龄相关性黄斑变性，糖尿病性视网膜病变，炎症性疾病等。
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公开(公告)号：US06420382B2
公开(公告)日：2002-07-16
申请号：US09788718
申请日：2001-02-20
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds which inhibit, regulate and/or modulate tyrosine kinase signal transduction, compositions which contain these compounds, and methods of using them to treat tyrosine kinase-dependent diseases and conditions, such as angiogenesis, cancer, tumor growth, atherosclerosis, age related macular degeneration, diabetic retinopathy, inflammatory diseases, and the like in mammals.
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