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    Vascular endothelial cell growth factor C subunit
    1.
    发明授权
    Vascular endothelial cell growth factor C subunit 失效
    血管内皮细胞生长因子C亚基

    公开(公告)号：US06569434B1

    公开(公告)日：2003-05-27

    申请号：US09699769

    申请日：2000-10-30

    申请人： Marvin L. Bayne ,  Kenneth A. Thomas, Jr.

    发明人： Marvin L. Bayne ,  Kenneth A. Thomas, Jr.

    IPC分类号： A61K3900

    CPC分类号： C12Q1/6897 ,  C07K14/52 ,  C12N15/10 ,  C12Q1/6876

    摘要： Vascular endothelial cell growth factor C subunit DNA is prepared by polymerase chain reaction techniques. The DNA encodes a protein that may exist as either a heterodimer or homodimer. The protein is a mammalian vascular endothelial cell mitogen and as such is useful for the promotion of vascular development and repair. This unique growth factor is also useful in the promotion of tissue repair.

    摘要翻译： 通过聚合酶链反应技术制备血管内皮细胞生长因子C亚基DNA。 DNA编码可能以异二聚体或同二聚体存在的蛋白质。 蛋白质是哺乳动物血管内皮细胞丝裂原，因此可用于促进血管发育和修复。 这种独特的生长因子也可用于促进组织修复。

    Inhibitor of vascular endothelial cell growth factor
    4.
    发明授权
    Inhibitor of vascular endothelial cell growth factor 失效
    血管内皮细胞生长因子抑制剂

    公开(公告)号：US08034772B2

    公开(公告)日：2011-10-11

    申请号：US12322800

    申请日：2009-02-06

    申请人： Richard L. Kendall ,  Kenneth A. Thomas, Jr.

    发明人： Richard L. Kendall ,  Kenneth A. Thomas, Jr.

    IPC分类号： A61K38/17 ,  C07K14/715 ,  C07K14/435 ,  C07K14/515

    CPC分类号： C07K14/71 ,  A61K38/00 ,  C07K14/715

    摘要： The vascular endothelial cell growth factor (VEGF) inhibitors of the present invention are naturally occurring or recombinantly engineered soluble forms with or without a C-terminal transmembrane region of the receptor for VEGF, a very selective growth factor for endothelial cells. The soluble forms of the receptors will bind the growth factor with high affinity but do not result in signal transduction. These soluble forms of the receptor bind VEGF and inhibit its function.

    摘要翻译： 本发明的血管内皮细胞生长因子（VEGF）抑制剂是具有或不具有VEGF受体的C末端跨膜区的天然存在或重组工程可溶形式，VEGF是内皮细胞的非常选择性生长因子。 受体的可溶形式将以高亲和力结合生长因子，但不会导致信号转导。 受体的这些可溶形式结合VEGF并抑制其功能。

    Vascular endothelial cell growth factor II
    6.
    发明授权
    Vascular endothelial cell growth factor II 失效
    血管内皮细胞生长因子II

    公开(公告)号：US5726152A

    公开(公告)日：1998-03-10

    申请号：US299185

    申请日：1994-08-31

    申请人： Marvin L. Bayne ,  Gregory L. Conn ,  Kenneth A. Thomas, Jr.

    发明人： Marvin L. Bayne ,  Gregory L. Conn ,  Kenneth A. Thomas, Jr.

    IPC分类号： C07K14/52 ,  A61K38/18 ,  C07K14/475

    CPC分类号： C07K14/52

    摘要： Vascular endothelial cell growth factor II is purified from the culture media used to maintain mammalian glioma cells. The protein is a heterodimer, stimulates mitogenesis of mammalian vascular endothelial cells and is useful for the promotion of vascular development and repair. This unique growth factor is also useful in the promotion of tissue repair.

    摘要翻译： 从用于维持哺乳动物神经胶质瘤细胞的培养基中纯化血管内皮细胞生长因子II。 蛋白质是异二聚体，刺激哺乳动物血管内皮细胞的有丝分裂，有助于促进血管发育和修复。 这种独特的生长因子也可用于促进组织修复。

    Brain derived and recombinant acidic fibroblast growth factor
    9.
    发明授权
    Brain derived and recombinant acidic fibroblast growth factor 失效
    脑源性和重组酸性成纤维细胞生长因子

    公开(公告)号：US5401832A

    公开(公告)日：1995-03-28

    申请号：US951365

    申请日：1992-09-25

    申请人： David L. Linemeyer ,  Linda J. Kelly ,  Guillermo Gimenez-Gallego ,  Kenneth A. Thomas, Jr.

    发明人： David L. Linemeyer ,  Linda J. Kelly ,  Guillermo Gimenez-Gallego ,  Kenneth A. Thomas, Jr.

    IPC分类号： A61K35/12 ,  A61K38/00 ,  A61K38/18 ,  A61L27/50 ,  C07K14/50 ,  C12N5/071 ,  C12N5/077 ,  A61K37/36

    CPC分类号： C07K14/501 ,  A61K38/1825 ,  A61L27/507 ,  A61K35/12

    摘要： Acidic fibroblast growth factor (aFGF) is isolated and purified from human brain tissue. The distinctive and complete amino acid sequences of both bovine and human aFGFs are determined and herein disclosed. Unique genes coding for these disclosed amino acid sequences are constructed. The bovine gene is derived from reverse translation of the aFGF amino acid sequence with unique restriction sites included while the human gene is derived by specific point mutations of the bovine gene. Each gene construct is inserted into an expression vector which is used to transform an appropriate host. The transformed host cells produce recombinant aFGF (r-aFGF), human or bovine, which is purified and has activity equivalent to the native protein. Both recombinant and purified brain-derived human and bovine aFGF are active mitogens for mesoderm and neuroectoderm-derived cells in culture, and promote wound healing of soft tissue, cartilaginous tissue and musculo-skeletal tissue. Acidic fibroblast growth factor, recombinant and purified brain-derived, is also useful for the growth of vascular endothelial cells and for coverage of polymeric vascular grafts; growth of such cultures on tubular supports for production of blood vessles for implantation; and stimulation or facilitation of blood vessel growth and repair in vivo.

    摘要翻译： 酸性成纤维细胞生长因子（aFGF）从人脑组织中分离纯化。 确定牛和人aFGF的独特和完整的氨基酸序列，并在此公开。 构建编码这些公开的氨基酸序列的唯一基因。 牛基因源自aFGF氨基酸序列的反向翻译，其中包含具有独特的限制性位点，而人基因是通过牛基因的特异性点突变得到的。 将每个基因构建体插入到用于转化合适宿主的表达载体中。 转化的宿主细胞产生重组aFGF（r-aFGF），人或牛，其被纯化并具有与天然蛋白质相当的活性。 重组和纯化的脑源性人和牛aFGF都是培养中的中胚层和神经外胚层衍生细胞的活性丝裂原，并促进软组织，软骨组织和肌肉 - 骨骼组织的伤口愈合。 酸性成纤维细胞生长因子，重组和纯化的脑源性，也可用于血管内皮细胞的生长和覆盖聚合血管移植物; 这种培养物在管状支架上的生长用于生产用于植入的血管; 并在体内刺激或促进血管生长和修复。