公开(公告)号：US06544395B1

公开(公告)日：2003-04-08

申请号：US09180320

申请日：1999-07-15

申请人： Mark E. Merchant ,  Philip A. Guadagno ,  Robert J. Sarrine ,  Suzan Robinson ,  James Robert Markus Sanford ,  Henry Garsee ,  Eric H. Petersen ,  Tipton L. Golias

发明人： Mark E. Merchant ,  Philip A. Guadagno ,  Robert J. Sarrine ,  Suzan Robinson ,  James Robert Markus Sanford ,  Henry Garsee ,  Eric H. Petersen ,  Tipton L. Golias

IPC分类号： G01N2726

CPC分类号： G01N27/44743 ,  Y10T436/2575

摘要： Novel apparatuses and methods for depositing or placing substances on substrates or plates are described. The invention relates to automated and semiautomated apparatuses and methods for controlled volume and precise placement of substances on substrates. Combinations of applicator tips, applicator tip assemblies, applicator reservoirs, applicator holders and movable racks precisely and accurately place samples and testing chemicals on substrates. Applicator tips particularly useful for dunk transfer and deposit processes and for carrying substances are disclosed. Apparatuses for precisely moving applicator holders, applicator reservoirs and tips are disclosed. The methods and apparatuses also have features for pre-loading substances on applicators and applicator reservoirs and precisely delivering the preloaded substances to substrates.

摘要翻译： 描述了用于将物质沉积或放置在基板或板上的新颖的装置和方法。 本发明涉及用于物质在基片上的受控体积和精确放置的自动化和半自动化设备和方法。 涂抹器尖端，涂抹器末端组件，涂敷器储存器，涂抹器支架和活动架的组合精确而准确地将样品和测试化学品放在基材上。 特别适用于扣篮转移和沉积过程以及携带物质的施用器技巧。 公开了用于精确移动施加器保持器，施加器容器和尖端的装置。 所述方法和装置还具有用于在施用器和施加器储存器上预加载物质并将预加载物质精确地递送到基底的特征。

公开(公告)号：US6165541A

公开(公告)日：2000-12-26

申请号：US301622

申请日：1999-04-29

申请人： Mark E. Merchant ,  Philip A. Guadagno ,  Suzan Robinson

发明人： Mark E. Merchant ,  Philip A. Guadagno ,  Suzan Robinson

IPC分类号： G01N33/561 ,  G01N27/447 ,  B05D1/26 ,  B05D1/32 ,  C12N11/12 ,  G01N21/01

CPC分类号： G01N27/44717 ,  G01N27/44704 ,  G01N27/44726

摘要： An improvement in the immunofixation electrophoresis procedure for detecting proteins in serum, urine or cerebral spinal fluids. Samples are placed on a gel and subjected to electrophoresis for resolving or separating proteins. Thereafter, antisera are applied to the sample areas through openings located on a template. The template includes projections and, the template substantially precludes cross-contamination and the adverse effects of ambient conditions on the integrity of the fluid, such as by the projections contacting, depressing or cutting into the gel to form closed cavities.

摘要翻译： 用于检测血清，尿液或脑脊髓液中蛋白质的免疫固定电泳方法的改进。 将样品置于凝胶上并进行电泳以分离或分离蛋白质。 此后，通过位于模板上的开口将抗血清施加到样品区域。 模板包括突起，并且模板基本上排除了交叉污染以及环境条件对流体完整性的不良影响，例如通过突起接触，压下或切入凝胶以形成闭合腔。