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公开(公告)号：US5196167A
公开(公告)日：1993-03-23
申请号：US697419
申请日：1991-05-09
IPC分类号： G01N33/72
CPC分类号： G01N33/726
摘要： A test sheet for the determination of the presence of a substance having peroxidase-like activity in a throw-in-the-bowl fecal occult blood test, includes a specimen test area and a positive control area. The test area has deposited thereon a test ink having at least one oxygen donor reagent and a chromogen reagent capable of being oxidized by the oxygen donor in the presence of blood or a substance having peroxidase-like activity, to provide a visually observable change of color. The test ink also includes a water soluble polymer for immobilizing the chromogen and oxygen donor. The positive control area has deposited thereon the test ink and a substance having the peroxidase-like activity.
摘要翻译： 用于测定在碗内粪便潜血试验中具有过氧化物酶样活性的物质的存在的试验片包括试样试验区域和阳性对照区域。 测试区域上沉积有具有至少一种氧供体试剂和能够在血液或具有过氧化物酶样活性的物质存在下被氧供体氧化的染色剂的测试油墨，以提供视觉上可观察到的颜色变化 。 测试油墨还包括用于固定色原体和氧供体的水溶性聚合物。 阳性对照区域在其上沉积有测试油墨和具有过氧化物酶样活性的物质。
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2.发明授权Method of formulating a test ink for a fecal occult blood test product 失效用于制造一种FECAL OCCULT血液试验产品的测试方法
公开(公告)号：US5192501A
公开(公告)日：1993-03-09
申请号：US333828
申请日：1989-04-04
CPC分类号： G01N33/726
摘要： A method of formulating a test ink for a fecal occult blood test product including the steps of: (a) providing at least one chromogen reagent in a first solution; (b) providing a moisture barrier which is a water-soluble polymer; (c) adding at least one oxygen donor reagent to the moisture barrier; (d) adding at least one color enhancer to the result of step (c) to thereby form a second solution; and (e) adding the second solution to the first solution.
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公开(公告)号：US4647541A
公开(公告)日：1987-03-03
申请号：US691954
申请日：1985-01-16
CPC分类号： C12Q1/28 , G01N33/726 , Y10S436/904
摘要： A test kit for preparing a chemical test pad used in testing for the presence of occult blood in a specimen. The test kit is a foil package enclosing an absorbant pad bearing a peroxygen agent and a solution of guaiac in alcohol in a separate packet or compartment from the absorbant pad. The separate packet or compartment being rupturable by applying hand pressure to the outside of the foil package to mix the peroxygen agent powder on the test pad and the guaiac solution prior to removing the absorbant pad from the foil package. The method relates to performing a medical test by activating a test pad bearing one reagent by applying another reagent thereto while remaining wholly within a protective foil package. According to the method a test pad containing the peroxygen agent is wetted with a solution of guaiac in alcohol prior to removal from the protective foil package and exposure to a specimen of fecal material and water in a test for occult blood.
摘要翻译： 用于制备用于测试样品中隐藏血液的存在的化学测试垫的测试试剂盒。 测试试剂盒是将包含过氧化剂的吸收垫和在酒精中的愈创木酮溶液与吸收垫隔开的单独的包装或隔室中的箔包装。 在从箔包装件中取出吸收垫之前，通过将手压施加到箔包装的外部以将过氧化剂粉末混合在测试垫和愈创木酚溶液上来使单独的包装或隔间破裂。 该方法涉及通过在完全保持在保护箔包装内的同时施加另一种试剂来激活具有一种试剂的测试垫进行医学测试。 根据该方法，在从保护箔包装中取出之前，用愈创木酚在醇中的溶液润湿含有过氧化剂的试验片，并在潜血试验中暴露于粪便物质和水样品。
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公开(公告)号：US06875614B2
公开(公告)日：2005-04-05
申请号：US10466174
申请日：2002-01-11
申请人： Philip A. Guadagno
发明人： Philip A. Guadagno
CPC分类号： G01N33/721 , G01N33/725 , Y10T436/107497
摘要： An improved fecal occult blood test having a matrix such as paper that is treated, imprinted or impregnated with a test reagent capable of undergoing a chromogen reaction is disclosed. The improvement relates to a novel developing solution in which the water to alcohol ratio is adjusted to enhance the sensitivity of the test.
摘要翻译： 公开了一种改进的粪便隐血试验，其具有用能够经历色原反应的测试试剂处理，印迹或浸渍的基质如纸。 该改进涉及一种新的显影溶液，其中调节水与醇的比例以提高测试的灵敏度。
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公开(公告)号：US5702913A
公开(公告)日：1997-12-30
申请号：US364525
申请日：1989-06-12
申请人： Philip A. Guadagno
发明人： Philip A. Guadagno
CPC分类号： G01N33/72 , G01N33/528 , Y10S435/81
摘要： An improved chromogen-reagent test system for a slide, test kit or the like has particular utility in the testing of fecal specimens for occult blood. The chromogen-reagent system may include the use of colorless guaiac which, in the presence of a developing solution and a catalyst, is oxidized to yield a predetermined color such as blue. Hydrogen peroxide is used as the developing solution and hemoglobin in the fecal specimen functions as the catalyst. The chromogen-reagent test system includes an indicator area for determining if the guaiac and the developing solution are functioning properly, i.e., the test system of the present invention verifies that the guaiac has not lost its activity nor been improperly catalyzed and that the hydrogen peroxide has not lost its activity. The indicator area includes a catalyst which has a greater stability than blood, in respect to adverse environmental conditions, such that a determination can be made if the reagents are functioning properly.
摘要翻译： 用于幻灯片，测试试剂盒等的改进的色原试剂测试系统在用于隐匿血液的粪便标本的测试中具有特别的用途。 色原试剂系统可以包括使用无色愈伤组织，其在显影溶液和催化剂的存在下被氧化以产生预定的颜色，例如蓝色。 使用过氧化氢作为显影液，粪便样品中的血红蛋白作为催化剂。 色原试剂测试系统包括用于确定愈创木药和显影溶液是否正常工作的指示剂区域，即本发明的测试系统验证愈创木药品没有失去活性，也没有被不正确地催化，并且过氧化氢 没有失去活动。 指示区域包括相对于不利的环境条件具有比血液更大的稳定性的催化剂，使得如果试剂正常运行，则可以进行确定。
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公开(公告)号：US5516402A
公开(公告)日：1996-05-14
申请号：US478369
申请日：1995-06-07
申请人： Robert J. Sarrine , Henry A. Garsee , Charles D. Kelley , Michael T. Everitt , Earl W. Boone , Philip A. Guadagno , Eric H. Petersen , Tipton L. Golias
发明人： Robert J. Sarrine , Henry A. Garsee , Charles D. Kelley , Michael T. Everitt , Earl W. Boone , Philip A. Guadagno , Eric H. Petersen , Tipton L. Golias
IPC分类号： G01N21/64 , C12Q1/48 , G01N27/447 , G01N35/10 , G01N27/26
CPC分类号： G01N27/44782
摘要： An electrophoresis apparatus for automatically performing medical assays includes an electrophoresis platform which cooperates with a gantry assembly. The electrophoresis platform and the gantry assembly are movable along paths that are perpendicular to each other. An applicator assembly includes pipettes which transfer fluid samples from a specimen tray to an electrophoresis plate mounted on the electrophoresis platform. The electrophoresis platform then moves to a position into the gantry assembly, where electrophoresis is conducted to separate the samples into different fractions. The electrophoresis platform then moves beneath a reagent pouring station where a reagent is applied to make the separated fractions fluoresce under ultraviolet light. The electrophoresis platform is then moved beneath the gantry assembly again, and an air knife in the gantry assembly spreads the reagent. After incubation and drying of the electrophoresis plate, the electrophoresis platform and gantry assembly are moved relative to one another while the electrophoresis plate is read with the aid of ultraviolet lamps and a photomultiplier tube mounted in the gantry assembly. The gain of the photomultiplier tube is automatically adjusted and the data gathered is automatically edited to remove background noise. The edited results can be printed or displayed on a video monitor. Techniques for calibrating the electrophoresis apparatus are also disclosed.
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公开(公告)号：US5217874A
公开(公告)日：1993-06-08
申请号：US697420
申请日：1991-05-09
IPC分类号： G01N33/72
CPC分类号： G01N33/726 , Y10S435/805 , Y10S436/904
摘要： A test sheet for the determination of the presence of a substance having peroxidase-like activity in a throw-in-the-bowl fecal occult blood test, includes a specimen test area and a positive control area. The test area has deposited thereon a test ink having at least one oxygen donor reagent and a chromogen reagent capable of being oxidized by the oxygen donor in the presence of blood or a substance having peroxidase-like activity, to provide a visually observable change of color. The test ink also includes a water soluble polymer for immobilizing the chromogen and oxygen donor. The positive control area has deposited thereon the test ink and a substance having the peroxidase-like activity.
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公开(公告)号：US5045173A
公开(公告)日：1991-09-03
申请号：US527354
申请日：1990-05-23
IPC分类号： G01N27/447
CPC分类号： G01N27/44704
摘要： An electrophoretic gel container for protecting an electrophoresis plate during shipment and storage, the electrophoresis plate being the type including a substrate having a major surface and a gel layer adhered to a portion of the major surface with the substrate including a peripheral portion free of the gel layer. The container includes a top portion and a bottom portion which are sealingly engageable with one another. The top and bottom portions have cooperating projections such that the top and bottom may be interlocked together. The gel layer substrate includes alignment apertures and the container includes alignment sockets in the bottom portion and locking pins in the top portion. The alignment sockets extend through the alignment apertures in the electrophoresis plate and the locking pins engage the alignment sockets to further secure the electrophoresis plate against movement. The container top portion is provided with stacking posts to support and distribute weight when a plurality of containers are stacked vertically.
摘要翻译： 一种用于在运输和储存期间保护电泳板的电泳凝胶容器，电泳板是包括具有主表面的基底和粘附到主表面的一部分的凝胶层的类型，基底包括不含凝胶的周边部分 层。 容器包括彼此密封地接合的顶部和底部。 顶部和底部具有协作突起，使得顶部和底部可以互锁在一起。 凝胶层基材包括对准孔，并且容器包括底部中的对准插座和顶部中的锁定销。 对准插座延伸穿过电泳板中的对准孔，并且锁定销接合对准插座，以进一步固定电泳板抵抗运动。 当多个容器垂直堆叠时，容器顶部设置有用于支撑和分配重量的堆垛柱。
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公开(公告)号：US4892639A
公开(公告)日：1990-01-09
申请号：US74584
申请日：1987-07-17
IPC分类号： G01N27/447
CPC分类号： G01N27/44704
摘要： An improved electrophoresis plate and method of making same includes a plate having an inert substrate and an electrophoretic medium formed on the substrate. The electrophoretic medium includes, as a part thereof, buffer blocks or buffer reservoirs, more specifically, relatively thick deposits of the electrophoretic medium. The electrophoretic medium buffer is positioned in a predetermined location relative to alignment apertures in the substrate.The method of making the electrophoresis plate of the present invention includes priming the substrate with electrophoretic medium and thereafter forming, such as by casting or molding, the electrophoretic medium with the buffer blocks on the primed substrate.
摘要翻译： 改进的电泳板及其制造方法包括具有惰性基板和形成在基板上的电泳介质的板。 作为其一部分的电泳介质包括缓冲块或缓冲储存器，更具体地，电泳介质的沉积物相对较厚。 电泳介质缓冲液位于相对于衬底中的对准孔的预定位置。 制造本发明的电泳板的方法包括用电泳介质引发底物，然后通过浇铸或模塑形成具有缓冲块的电泳介质。
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公开(公告)号：US4890247A
公开(公告)日：1989-12-26
申请号：US211761
申请日：1988-06-27
IPC分类号： G01N27/447
CPC分类号： G01N27/44721 , G01N27/44782
摘要： An electrophoresis machine is disclosed in which after a microporous support strip and a sample plate are placed in the machine, all electrophoresis processing, scanning and densitometer functions are automatically performed under computer control. The machine includes apparatus for automatic pipetting of liquid samples from the sample plate to the surface of the support strip, apparatus for applying electrophoresis current to the strip while simultaneously cooling it, apparatus for applying and spreading flourescent staining reagent to the strip, and apparatus for incubating the strip and subsequently drying it. A T.V. camera, mounted to a flourescent scanning box enlosing the application plate, in cooperation with digital processing equipment, electronically scans electrophoresically longitudinally displaced components of the samples for determining relative component densities. An alternative scanning apparatus including a collimator and photomultiplier is also disclosed.
摘要翻译： 公开了一种电泳机，其中在将微孔支撑条和样品板放置在机器中之后，在计算机控制下自动执行所有电泳处理，扫描和密度计功能。 该机器包括用于将液体样品从样品板自动移液到支撑条的表面的装置，用于在同时冷却条件下向条带施加电泳电流的装置，用于将荧光染色试剂施加并铺展到条带上的装置，以及用于 孵育条并随后干燥。 与数字处理设备协作安装到包含应用板的荧光扫描盒的T.V摄像机电子扫描样品的电泳纵向移位的组分以确定相对组分密度。 还公开了一种包括准直器和光电倍增管的替代扫描装置。
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