公开(公告)号：US07933646B2

公开(公告)日：2011-04-26

申请号：US11837987

申请日：2007-08-13

申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

IPC分类号： A61B5/04

CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

公开(公告)号：US07280867B2

公开(公告)日：2007-10-09

申请号：US10687571

申请日：2003-10-15

申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

IPC分类号： A61B5/04

CPC分类号： A61B5/04012 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7217 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  Y10S128/92

摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件（例如癫痫发作），与治疗疗法相关联的更新治疗参数相关联的检测簇。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法的每个连续的应用组或每个第n个检测簇进行更新。

公开(公告)号：US08738136B2

公开(公告)日：2014-05-27

申请号：US11837994

申请日：2007-08-13

申请人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

发明人： Mark G. Frei ,  Ivan Osorio ,  Nina M. Graves ,  Scott F. Schaffner ,  Mark T. Rise ,  Jonathon E. Giftakis ,  David L. Carlson

IPC分类号： A61N1/36

CPC分类号： A61M5/1723 ,  A61B5/04001 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/6843 ,  A61B5/721 ,  A61N1/36025 ,  A61N1/36064 ,  A61N1/36082 ,  A61N1/361

摘要： Apparatus and method detect a detection cluster that is associated with a neurological event, such as a seizure, of a nervous system disorder and update therapy parameters that are associated with a treatment therapy. The occurrence of the detection cluster is detected when the maximal ratio exceeds an intensity threshold. If the maximal ratio drops below the intensity threshold for a time interval that is less than a time threshold and subsequently rises above the intensity threshold, the subsequent time duration is considered as being associated with the detection cluster rather than being associated with a different detection cluster. Consequently, treatment of the nervous system disorder during the corresponding time period is in accordance with one detection cluster. Treatment therapy may be provided by providing electrical stimulation, drug infusion or a combination. Therapy parameters may be updated for each mth successive group of applications of the treatment therapy or for each nth detection cluster.

摘要翻译： 装置和方法检测与神经系统疾病的神经系统事件如癫痫发作相关联的检测簇，以及与治疗疗法相关联的更新治疗参数。 当最大比例超过强度阈值时，检测到簇的出现。 如果最小比率在低于时间阈值的时间间隔下降到低于强度阈值，并且随后升高到强度阈值以上，则后续持续时间被认为与检测集群相关联，而不是与不同的检测集群相关联 。 因此，在相应时间段期间治疗神经系统疾病是根据一个检测群。 可以通过提供电刺激，药物输注或组合来提供治疗治疗。 治疗参数可以针对治疗疗法或第n个检测簇的每个第m个连续的应用组进行更新。

公开(公告)号：US08579786B2

公开(公告)日：2013-11-12

申请号：US10687344

申请日：2003-10-15

申请人： Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Nina M. Graves ,  Scott F. Schaffner ,  Jonathon E. Giftakis ,  Mark T. Rise ,  Jonathan C. Werder

发明人： Ivan Osorio ,  Mark G. Frei ,  Naresh C. Bhavaraju ,  Thomas E. Peters ,  Nina M. Graves ,  Scott F. Schaffner ,  Jonathon E. Giftakis ,  Mark T. Rise ,  Jonathan C. Werder

IPC分类号： A61N2/00

CPC分类号： A61N1/08 ,  A61B5/0476 ,  A61B5/4094 ,  A61B5/7275 ,  A61N1/36025 ,  A61N1/36082 ,  A61N1/361 ,  A61N1/37217

摘要： Apparatus and method support a neurological event screening for a medical device. The medical device assists a user in determining a configuration of the medical device for delivering an effective treatment for a nervous system disorder. The medical device detects a neurological event, such as a seizure, and reports a neurological event focus location and a neurological event spread to the user. The user may use the information to provide a configuration of a therapeutic delivery unit and associated therapy parameters. Therapeutic treatment is delivered to the patient, and the medical device is provided an indication of the patient's acceptance to the treatment. The user may modify the configuration and therapy parameters in order to achieve efficacy and acceptance. Depending upon the patient's acceptance, therapy is applied in either an open loop mode or a closed loop mode. The medical device determines whether the treatment is successful in accordance with a criterion.

摘要翻译： 装置和方法支持用于医疗装置的神经事件筛查。 医疗装置帮助用户确定医疗装置的配置以递送用于神经系统障碍的有效治疗。 医疗装置检测诸如癫痫发作的神经系统事件，并向用户报告神经系统事件焦点位置和神经系统事件。 用户可以使用该信息来提供治疗递送单元的配置和相关联的治疗参数。 向患者传送治疗性治疗，并且向患者提供患者接受治疗的指示。 用户可以修改配置和治疗参数，以达到功效和验收。 根据患者的接受程度，治疗以开环模式或闭环模式应用。 医疗设备根据标准确定治疗是否成功。

公开(公告)号：US08594798B2

公开(公告)日：2013-11-26

申请号：US10687289

申请日：2003-10-15

申请人： Ivan Osorio ,  Mark G. Frei ,  Mark T. Rise ,  Scott F. Schaffner ,  Nina M. Graves

发明人： Ivan Osorio ,  Mark G. Frei ,  Mark T. Rise ,  Scott F. Schaffner ,  Nina M. Graves

IPC分类号： A61N1/08

CPC分类号： A61N1/36025 ,  A61N1/08 ,  A61N1/36082

摘要： Apparatuses and methods support multi-modal operation of a medical device system for a nervous system disorder. The medical device system comprises an implanted component and an external component and supports a first feature and a second feature that are associated with the treatment therapy. The medical device system supports both features when the implanted component and the external component are coupled. If the external component is decoupled, the implanted component continues to support the first feature. Moreover, the embodiment may support a plurality of features during a treatment interval. Another aspect of the invention allows for modularly expanding a medical device system in order to add a feature that enhances existing functionality or that provides additional functionality. In an embodiment, a module that is associated with an external component of the medical device system supports the added feature.

摘要翻译： 装置和方法支持用于神经系统障碍的医疗装置系统的多模式操作。 医疗装置系统包括植入部件和外部部件，并且支撑与治疗疗法相关联的第一特征和第二特征。 当植入部件和外部部件联接时，医疗装置系统支持两个特征。 如果外部组件解耦，则植入组件继续支持第一个特征。 此外，该实施例可以在治疗间隔期间支持多个特征。 本发明的另一方面允许模块化地扩展医疗设备系统，以便添加增强现有功能或提供附加功能的特征。 在一个实施例中，与医疗设备系统的外部部件相关联的模块支持附加的特征。