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    Method and apparatus for detection of nervous system disorders
    5.
    发明授权
    Method and apparatus for detection of nervous system disorders 有权
    用于检测神经系统疾病的方法和装置

    公开(公告)号：US07979130B2

    公开(公告)日：2011-07-12

    申请号：US11677360

    申请日：2007-02-21

    申请人： David L Carlson ,  Eric J Panken ,  Touby A Drew ,  Jonathan C Werder

    发明人： David L Carlson ,  Eric J Panken ,  Touby A Drew ,  Jonathan C Werder

    IPC分类号： A61N1/36

    CPC分类号： A61B5/02405 ,  A61B5/0456 ,  A61B5/0476 ,  A61B5/0482 ,  A61B5/4094 ,  A61B5/7221 ,  A61B5/7275 ,  A61N1/36082 ,  A61N2/006 ,  G06F19/00 ,  G06K9/00543

    摘要： Systems and methods for detecting and/or treating nervous system disorders, such as seizures. Certain embodiments of the invention relate generally to implantable medical devices (IMDs) adapted to detect and treat nervous system disorders in patients with an IMD. Certain embodiments of the invention include detection of seizures based upon comparisons of long-term and short-term representations of physiological signals. Further embodiments of the invention include preparing for the delivery of therapy by warming up therapy delivery components prior to the expected delivery of therapy.

    摘要翻译： 用于检测和/或治疗神经系统疾病例如癫痫发作的系统和方法。 本发明的某些实施方案一般涉及适于检测和治疗患有IMD的患者的神经系统疾病的可植入医疗装置（IMD）。 本发明的某些实施方案包括基于生理信号的长期和短期表示的比较来检测癫痫发作。 本发明的其它实施方案包括通过在治疗的预期递送之前预热治疗递送成分来准备递送治疗。

    Controlling therapy based on sleep quality
    6.
    发明授权
    Controlling therapy based on sleep quality 有权
    基于睡眠质量控制治疗

    公开(公告)号：US07881798B2

    公开(公告)日：2011-02-01

    申请号：US11691430

    申请日：2007-03-26

    申请人： Keith A. Miesel ,  Kenneth T. Heruth ,  Jonathan C. Werder ,  Steve R. LaPorte ,  Nina M. Graves

    发明人： Keith A. Miesel ,  Kenneth T. Heruth ,  Jonathan C. Werder ,  Steve R. LaPorte ,  Nina M. Graves

    IPC分类号： A61N1/18

    CPC分类号： A61N1/36082

    摘要： A medical device, such as an implantable medical device (IMD), determines values for one or more metrics that indicate the quality of a patient's sleep, and controls delivery of a therapy based on the sleep quality metric values. For example, the medical device may compare a sleep quality metric value with one or more threshold values, and adjust the therapy based on the comparison. In some embodiments, the medical device adjusts the intensity of therapy based on the comparison, e.g., increases the therapy intensity when the comparison indicates that the patient's sleep quality is poor. In some embodiments, the medical device automatically selects one of a plurality of therapy parameter set available for use in delivering therapy based on a comparison sleep quality metric values associated with respective therapy parameter sets within the plurality of available therapy parameter sets.

    摘要翻译： 诸如可植入医疗装置（IMD）的医疗设备确定指示患者睡眠质量的一个或多个指标的值，并且基于睡眠质量量度值控制治疗的递送。 例如，医疗设备可以将睡眠质量度量值与一个或多个阈值进行比较，并且基于比较来调整治疗。 在一些实施例中，医疗装置基于比较来调整治疗的强度，例如当比较表明患者的睡眠质量差时，增加治疗强度。 在一些实施例中，医疗设备基于与多个可用治疗参数组内的各个治疗参数组相关联的比较睡眠质量量度值，自动选择可用于递送治疗的多个治疗参数集中的一个。

    SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION
    7.
    发明申请
    SEIZURE DISORDER EVALUATION BASED ON INTRACRANIAL PRESSURE AND PATIENT MOTION 审中-公开
    基于内分泌压力和患者运动的癫痫病症评估

    公开(公告)号：US20100121214A1

    公开(公告)日：2010-05-13

    申请号：US12359055

    申请日：2009-01-23

    申请人： Jonathon E. Giftakis ,  Nina M. Graves ,  Jonathan C. Werder ,  Eric J. Panken ,  Timothy J. Denison ,  Keith A. Miesel ,  Michele H. Herzog

    发明人： Jonathon E. Giftakis ,  Nina M. Graves ,  Jonathan C. Werder ,  Eric J. Panken ,  Timothy J. Denison ,  Keith A. Miesel ,  Michele H. Herzog

    IPC分类号： A61B5/0476 ,  A61B5/03 ,  A61B5/11 ,  A61B5/053

    CPC分类号： A61N1/0534 ,  A61B5/031 ,  A61B5/4094 ,  A61N1/36082

    摘要： Intracranial pressure of a patient may be monitored in order to evaluate a seizure disorder. In some examples, trends in the intracranial pressure over time may be monitored, e.g., to detect changes to the patient's condition. In addition, in some examples, a seizure metric may be generated for a detected seizure based on sensed intracranial pressures. The seizure metric may indicate, for example, an average, median, or highest relative intracranial pressure value observed during a seizure, a percent change from a baseline value during the seizure, or the time for the intracranial pressure to return to a baseline state after the occurrence of a seizure. In addition to or instead of intracranial pressure, patient motion or posture may be monitored in order to assess the patient's seizure disorder. For example, a seizure type or severity may be determined based on patient motion sensed during a seizure.

    摘要翻译： 可以监测患者的颅内压，以评估癫痫发作障碍。 在一些示例中，可以监测颅内压力随时间的趋势，例如以检测患者状况的变化。 此外，在一些示例中，可以基于感测的颅内压力产生针对检测到的发作的发作量度。 癫痫发作度数可以表示例如在癫痫发作期间观察到的平均值，中位数或最高相对颅内压值，在癫痫发作期间从基线值变化的百分比，或颅内压力回到基线状态的时间 发生癫痫发作。 除了或代替颅内压之外，可以监测患者的运动或姿势以评估患者的癫痫发作障碍。 例如，可以基于在癫痫发作期间感测到的患者运动来确定癫痫发作类型或严重程度。

    Target tracking system for determining bearing of a target
    10.
    发明授权
    Target tracking system for determining bearing of a target 失效
    用于确定目标的方位的目标跟踪系统

    公开(公告)号：US5095467A

    公开(公告)日：1992-03-10

    申请号：US582571

    申请日：1990-09-14

    申请人： David P. Olson ,  Jonathan C. Werder

    发明人： David P. Olson ,  Jonathan C. Werder

    IPC分类号： G01S3/801 ,  G01S3/805

    CPC分类号： G01S3/805 ,  G01S3/801

    摘要： A passive acoustic target tracking system includes three microphones arrayed respectively at corners of an equilateral triangle for sensing acoustic energy emitted by a target, such as a heavy vehicle, and generating separate streams of analog signals representative of the acoustic energy sensed at the triangle corners. Hardware of the tracking system receives the separate streams of analog signals from the microphones and conditions and converts the separate streams of analog signals from analog to digital form and outputs the separate streams as digital signals. Software of the tracking system receives the separate streams of digital signals and provides the bearing to the target emitting the sensed acoustic energy. The software includes a minimum residual correlation algorithm and a two-state kalman filter algorithm. The minimum residual correlation algorithm receives the separate streams of digital signals, performs correlations on the separate streams from pairs of the microphones, and produces a raw azimuth signal as a result of the correlation. The two-state kalman filter algorithm receives the raw azimuth signal, performs a two-state kalman filtering of the raw azimuth signal, and produces a smooth azimuth signal constituting the bearing to the target emitting the sensed acoustic energy.

    摘要翻译： 无源声目标跟踪系统包括分别排列在等边三角形的拐角处的三个麦克风，用于感测由诸如重型车辆的目标发出的声能，并且产生代表在三角形拐角处感测到的声能的单独的模拟信号流。 跟踪系统的硬件从麦克风接收单独的模拟信号流和条件，并将单独的模拟信号流从模拟形式转换为数字形式，并将单独的流作为数字信号输出。 跟踪系统的软件接收单独的数字信号流，并向发射感测声能的目标提供支撑。 该软件包括最小残差相关算法和双状态卡尔曼滤波算法。 最小残差相关算法接收单独的数字信号流，在与麦克风对成对的单独流上执行相关性，并产生作为相关结果的原始方位信号。 双状态卡尔曼滤波算法接收原始方位信号，对原始方位信号进行双状态卡尔曼滤波，并产生构成对发射感测声能的目标的方位角的平滑方位信号。