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公开(公告)号：US5989815A
公开(公告)日：1999-11-23
申请号：US848251
申请日：1997-04-29
摘要： The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
摘要翻译： 本发明涉及人类癌症中多重肿瘤抑制因子（MTS）基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及MTS基因中的种系突变及其在诊断黑素瘤，白血病，星形细胞瘤，成胶质细胞瘤，淋巴瘤，胶质瘤，霍奇金淋巴瘤，CLL和胰腺，乳腺，甲状腺，卵巢癌， 子宫，睾丸，肾，胃和直肠。 本发明还涉及在MTS基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 最后，本发明涉及用于癌症治疗的药物的筛选。
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公开(公告)号：US5624819A
公开(公告)日：1997-04-29
申请号：US474177
申请日：1995-06-07
IPC分类号： G01N33/574 , C07H21/00 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/82 , C07K16/18 , C07K16/28 , C07K16/32 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/11 , C12N15/12 , C12N15/28 , C12N15/63 , C12N15/79 , C12N15/85 , C12P21/00 , C12P21/02 , C12P21/06 , C12Q20060101 , C12Q1/68 , G01N20060101 , G01N33/53 , G01N33/566
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/156 , C12Q2600/172
摘要： The present invention relates to somatic mutations in the Multiple Tumor Suppressor (MTS) gene in human cancers and their use in the diagnosis and prognosis of human cancer. The invention further relates to germ line mutations in the MTS gene and their use in the diagnosis of predisposition to melanoma, leukemia, astrocytoma, glioblastoma, lymphoma, glioma, Hodgkin's lymphoma, CLL, and cancers of the pancreas, breast, thyroid, ovary, uterus, testis, kidney, stomach and rectum. The invention also relates to the therapy of human cancers which have a mutation in the MTS gene, including gene therapy, protein replacement therapy and protein mimetics. Finally, the invention relates to the screening of drugs for cancer therapy.
摘要翻译： 本发明涉及人类癌症中多重肿瘤抑制因子（MTS）基因的体细胞突变及其在人类癌症诊断和预后中的应用。 本发明还涉及MTS基因中的种系突变及其在诊断黑素瘤，白血病，星形细胞瘤，成胶质细胞瘤，淋巴瘤，胶质瘤，霍奇金淋巴瘤，CLL和胰腺，乳腺，甲状腺，卵巢癌， 子宫，睾丸，肾，胃和直肠。 本发明还涉及在MTS基因中具有突变的人类癌症的治疗，包括基因治疗，蛋白质替代疗法和蛋白质模拟物。 最后，本发明涉及用于癌症治疗的药物的筛选。
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