公开(公告)号：US06685718B1

公开(公告)日：2004-02-03

申请号：US09629771

申请日：2000-07-31

申请人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Thomas J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

发明人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Thomas J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

IPC分类号： A61B1732

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 当毛刺旋转时，聚合物管通过离心力膨胀。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。 该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。 当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。

公开(公告)号：US07252674B2

公开(公告)日：2007-08-07

申请号：US10770336

申请日：2004-02-02

申请人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Tom J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

发明人： Mark H. Wyzgala ,  Eric B. Hamilton ,  Tom J. Hiblar ,  Lixiao Wang ,  John J. Chen ,  Irina Nazarova ,  Nancy L. Haig ,  Sheng-Ping Zhong

IPC分类号： A61B17/32

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。 该系统包括具有设置在近端的磨料的消融毛刺。 当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。

公开(公告)号：US06096054A

公开(公告)日：2000-08-01

申请号：US178449

申请日：1998-10-23

申请人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

发明人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

IPC分类号： A61B17/00 ,  A61B17/22 ,  A61B17/32

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. Alternatively, the burr may include a polymeric tube that is coated with an abrasive and secured to the proximal end of the burr. When the burr is rotated, the polymeric tube expands by centrifugal force. Alternatively, the burr may comprise a metallic strip wound over a mandrel. When the strip is tightly coiled to the mandrel, its outer diameter decreases. The outer diameter of the burr increases as the metallic strip expands. In addition, the burr can be formed as a wire spring wound over a drive tube. The distal end of the spring is coupled to a nose cone that can move within a distal lumen in the drive tube. The maximum expansion of the burr is controlled by the distance that the nose cone can be retracted into the lumen. In addition, the present invention includes a burr having an indexable outer diameter. Various indexing mechanisms are disclosed for selectively increasing or decreasing the distance between a proximal and distal end of the burr. As the length of the burr changes, the outer diameter of a number of cutting blades is changed to allow a physician to create different sized lumens in a patient's vessel.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 或者，毛刺可以包括涂覆有研磨剂并固定到毛刺的近端的聚合物管。 当毛刺旋转时，聚合物管通过离心力膨胀。 或者，毛刺可以包括缠绕在心轴上的金属条。 当条带紧紧地卷绕到心轴上时，其外径减小。 毛边的外径随着金属条扩张而增加。 此外，毛刺可以形成为卷绕在驱动管上的线弹簧。 弹簧的远端联接到能够在驱动管内远端管腔内移动的鼻锥体。 毛刺的最大膨胀由鼻锥可以缩回到内腔的距离来控制。 此外，本发明包括具有可转位外径的毛刺。 公开了用于选择性地增加或减小毛刺的近端和远端之间的距离的各种分度机构。 随着毛刺的长度改变，许多切割刀片的外径被改变以允许医师在患者的血管中产生不同大小的腔。

公开(公告)号：US06554846B2

公开(公告)日：2003-04-29

申请号：US09967444

申请日：2001-09-28

申请人： Eric B. Hamilton ,  Tim Johnson

发明人： Eric B. Hamilton ,  Tim Johnson

IPC分类号： A61B1722

CPC分类号： A61B17/3207 ,  A61B17/22004 ,  A61B17/22012 ,  A61B17/320758 ,  A61B2017/320004

摘要： An ablative burr (100) that may be used for a medical procedure, such as an atherectomy, that does not require the user of an elongate flexible drive shaft. The burr comprises a main body (110) that is elastically connected to an abrasive shell member (130). One or more oscillatory driver(s) (150), such as a piezoelectric transducer, is disposed between the shell member and the main body to oscillate the shell with respect to the main body. Elastically compressible members (140, 142) are provided between the shell member and the main body member. The oscillatory drivers are preferably set or tuned to operate at a resonant frequency of the shell member whereby shell member amplitudes larger than the oscillatory driver amplitudes may be induced. Embodiments of longitudinally oscillatory burrs (100, 200) and rotationally oscillatory burrs (300, 400) are disclosed.

摘要翻译： 可用于诸如粥样斑块切除术的医疗程序的烧蚀毛刺（100），其不需要使用细长的柔性驱动轴。 毛刺包括弹性地连接到磨料壳构件（130）的主体（110）。 一个或多个振荡驱动器（150），例如压电换能器，被布置在壳体构件和主体之间，以相对于主体摆动壳体。 弹性可压缩构件（140,142）设置在壳构件和主体构件之间。 优选地，振荡驱动器被设置或调谐为以壳体部件的谐振频率工作，从而可以引起大于振荡驱动器振幅的壳体振幅。 公开了纵向振荡毛刺（100,200）和旋转振荡毛刺（300,400）的实施例。

公开(公告)号：US06416526B1

公开(公告)日：2002-07-09

申请号：US09589861

申请日：2000-06-08

申请人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

发明人： Mark Wyzgala ,  Donald Baumgarten ,  Lucas S. Gordon ,  Eric B. Hamilton ,  Matt Hefner ,  Tom Hiblar ,  Edward Wulfman

IPC分类号： A61B1732

CPC分类号： A61B17/320725 ,  A61B17/320758 ,  A61B2017/00557 ,  A61B2017/00867 ,  A61B2017/320004 ,  A61B2017/320733

摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. Alternatively, the burr may include a polymeric tube that is coated with an abrasive and secured to the proximal end of the burr. When the burr is rotated, the polymeric tube expands by centrifugal force. Alternatively, the burr may comprise a metallic strip wound over a mandrel. When the strip is tightly coiled to the mandrel, its outer diameter decreases. The outer diameter of the burr increases as the metallic strip expands. In addition, the burr can be formed as a wire spring wound over a drive tube. The distal end of the spring is coupled to a nose cone that can move within a distal lumen in the drive tube. The maximum expansion of the burr is controlled by the distance that the nose cone can be retracted into the lumen. In addition, the present invention includes a burr having an indexable outer diameter. Various indexing mechanisms are disclosed for selectively increasing or decreasing the distance between a proximal and distal end of the burr. As the length of the burr changes, the outer diameter of a number of cutting blades is changed to allow a physician to create different sized lumens in a patient's vessel.

摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 或者，毛刺可以包括涂覆有研磨剂并固定到毛刺的近端的聚合物管。 当毛刺旋转时，聚合物管通过离心力膨胀。 或者，毛刺可以包括缠绕在心轴上的金属条。 当条带紧紧地卷绕到心轴上时，其外径减小。 毛边的外径随着金属条扩张而增加。 此外，毛刺可以形成为卷绕在驱动管上的线弹簧。 弹簧的远端联接到能够在驱动管内远端管腔内移动的鼻锥体。 毛刺的最大膨胀由鼻锥可以缩回到内腔的距离来控制。 此外，本发明包括具有可转位外径的毛刺。 公开了用于选择性地增加或减小毛刺的近端和远端之间的距离的各种分度机构。 随着毛刺的长度改变，许多切割刀片的外径被改变以允许医师在患者的血管中产生不同大小的腔。