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公开(公告)号：US07252674B2
公开(公告)日：2007-08-07
申请号：US10770336
申请日：2004-02-02
申请人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Tom J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B17/32
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include an expandable polymeric balloon having a partially abrasive exterior surface. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes systems that are pulled proximally to remove portions of a lesion located in a patient's vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end. The burr may create a seal when expanded to block the ablated particulate so that an aspiration system can remove the particulate from the vasculature. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath.
摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括具有部分研磨外表面的可膨胀聚合气囊。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 另外，本发明还包括向近侧拉动以去除位于病人脉管系统中的病变部分的系统。 该系统包括具有设置在近端的磨料的消融毛刺。 当膨胀时，毛刺可以产生密封，以阻止消融的颗粒，使得吸气系统可以从脉管系统中除去颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封件。
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公开(公告)号：US06685718B1
公开(公告)日：2004-02-03
申请号：US09629771
申请日：2000-07-31
申请人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
发明人： Mark H. Wyzgala , Eric B. Hamilton , Thomas J. Hiblar , Lixiao Wang , John J. Chen , Irina Nazarova , Nancy L. Haig , Sheng-Ping Zhong
IPC分类号： A61B1732
CPC分类号： A61B17/320725 , A61B17/320758 , A61B2017/00557 , A61B2017/00867 , A61B2017/320004 , A61B2017/320733
摘要： An atherectomy burr has an operating diameter that is larger than the diameter of a catheter in which the burr is routed. The burr may include a polymeric balloon that is coated with an abrasive and that expands when the burr is rotated. When the burr is rotated, the polymeric tube expands by centrifugal force. The maximum expansion of the burr is controlled by an expansion mechanism. Various mechanisms are disclosed for controlling the maximum diameter of the burr thus preventing the burr from over expanding. In addition, the present invention includes a system for preventing the loose ablated particulate from reembolizing in the distal vasculature. The system includes an ablation burr that has abrasive disposed on the proximal end that is pulled back toward the guide catheter to ablate the lesion. The burr creates a seal when expanded to block the ablated particulate so that the aspiration system can remove the particulate from the patient vessel or stent. Alternatively, the burr system may include a self expanding seal that is deployed out of the aspiration sheath so that a slight vacuum can remove the large loose particulate form, the patient's vessel or stent.
摘要翻译： 粥样斑块切除术毛刺的操作直径大于其中布置毛刺的导管的直径。 毛刺可以包括涂覆有磨料的聚合物气球，并且当毛刺旋转时膨胀。 当毛刺旋转时，聚合物管通过离心力膨胀。 毛刺的最大膨胀由膨胀机构控制。 公开了用于控制毛刺的最大直径的各种机构，从而防止毛刺过度膨胀。 此外，本发明还包括一种用于防止松散的消融颗粒在远端脉管系统中再栓塞的系统。 该系统包括消融毛刺，其具有设置在近端上的磨料，其被拉回导向导管以烧蚀病变。 当膨胀时，毛刺产生密封以阻挡消融的颗粒，使得吸气系统可以从患者的血管或支架中移除颗粒。 或者，毛刺系统可以包括从抽吸鞘部署出来的自膨胀密封，使得轻微的真空可以从患者的血管或支架中移除大的松散颗粒。
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公开(公告)号：US08620406B2
公开(公告)日：2013-12-31
申请号：US10763690
申请日：2004-01-23
申请人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译： 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。
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公开(公告)号：US20050165301A1
公开(公告)日：2005-07-28
申请号：US10763690
申请日：2004-01-23
申请人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott Smith , Steven Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译： 描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。 在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。 导电路径能够连接到电流源。 医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。
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公开(公告)号：US08435285B2
公开(公告)日：2013-05-07
申请号：US10962567
申请日：2004-10-13
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0076 , A61F2220/0008 , A61F2220/0041 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2250/0067 , A61L31/129 , A61L31/146 , B05D1/002
摘要： An endoprosthesis comprising a stent, a cover fully covering the stent wherein the cover has variable porosity in the radial direction; and an adhesion layer connecting the stent to the cover. Another aspect of the invention is a method of implanting an endoprosthesis which includes a stent, providing a cover with variable porosity in the radial direction, connecting the stent to the cover with an adhesion layer to form a covered stent, and implanting the covered stent within a body lumen of a patient.
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公开(公告)号：US07792568B2
公开(公告)日：2010-09-07
申请号：US10390202
申请日：2003-03-17
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61B90/39 , A61B2090/3933 , A61B2090/3954 , A61M25/00 , A61M25/0009 , A61M25/0127 , A61M2025/1079
摘要： A medical device includes a body, a member in the body, and a contrast agent in the member. The device can be visible by magnetic resonance imaging.
摘要翻译： 医疗装置包括主体，身体中的构件和构件中的造影剂。 该装置可以通过磁共振成像可见。
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公开(公告)号：US20070020307A1
公开(公告)日：2007-01-25
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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8.发明授权
公开(公告)号：US5869127A
公开(公告)日：1999-02-09
申请号：US877825
申请日：1997-06-18
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/10 , A61L31/16 , C03C17/32 , C08J7/04 , C08L33/02 , C08L75/00 , C08L75/04 , C09D201/00 , B05D3/10 , A61L33/00 , B05D3/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L31/10 , A61L2300/208 , A61L2300/21 , A61L2300/236 , A61L2300/25 , A61L2300/42 , A61L2300/608 , A61L2300/61 , Y10S623/92
摘要： Disclosed is a method of enhancing the biocompatibility of a substrate by providing the substrate with a continuous bio-active surface coating. This method includes applying to the substrate a first coating which includes an aqueous dispersion or emulsion of a polymer containing an organic acid functional group and an excess of a polyfunctional cross-linking agent which is reactive with the organic acid groups of the polymer. A continuous bio-active surface coating is then formed over the dried first coating by applying thereover a bio-active agent containing an organic acid functional group or metal salt thereof. The first and second coatings are then dried to covalently bond the organic acid functional groups of the bio-active agent to the polymer through the excess unreacted polyfunctional cross-linking agent.
摘要翻译： 公开了通过向基材提供连续的生物活性表面涂层来提高基底的生物相容性的方法。 该方法包括向基材施加第一涂层，该涂层包括含有有机酸官能团的聚合物的水性分散体或乳液，以及过量的与聚合物的有机酸基团反应的多官能交联剂。 然后通过在其上施加含有有机酸官能团或其金属盐的生物活性剂，在干燥的第一涂层上形成连续的生物活性表面涂层。 然后干燥第一和第二涂层，以通过过量的未反应的多官能交联剂将生物活性剂的有机酸官能团与聚合物共价键合。
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公开(公告)号：US08722074B2
公开(公告)日：2014-05-13
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
IPC分类号： A61F2/02
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译： 本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。 本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。 辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。
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10.发明授权公开(公告)号：US07483732B2
公开(公告)日：2009-01-27
申请号：US10826960
申请日：2004-04-15
CPC分类号： G01R33/285
摘要： Medical devices incorporate therein imaging materials having selected MRI detectable nuclei to provide useful magnetic resonance images of the medical devices and proximate body tissue. Also, a method generates MRI images of such a medical device, and involves performing first and second MRI processes on a body portion including at least a portion of the medical device to obtain, respectively, first and second image data. The first MRI process is adapted to detect MRI detectable nuclei present in the proximate body tissue, and the second MRI process is adapted to detect the selected MRI detectable nuclei contained in the device's imaging material. The selected MRI detectable nuclei incorporated in the imaging material is not the same nuclei that the first MRI process is adapted to detect. The second image data are combined with the first image data to produce image data for the medical device and the proximate body tissue.
摘要翻译： 医疗装置包括具有选定的MRI可检测核的成像材料，以提供医疗装置和邻近身体组织的有用的磁共振图像。 此外，一种方法产生这种医疗装置的MRI图像，并且涉及在包括医疗装置的至少一部分的主体部分上执行第一和第二MRI处理，以分别获得第一和第二图像数据。 第一MRI过程适于检测存在于邻近身体组织中的MRI可检测核，并且第二MRI过程适于检测包含在装置的成像材料中的所选择的MRI可检测核。 在成像材料中并入的所选择的MRI检测核并不是第一个MRI过程适用于检测的核。 第二图像数据与第一图像数据组合以产生用于医疗装置和邻近身体组织的图像数据。
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