Methods for quantitative analysis by tandem mass spectrometry
    1.
    发明申请
    Methods for quantitative analysis by tandem mass spectrometry 有权
    串联质谱定量分析方法

    公开(公告)号:US20050165560A1

    公开(公告)日:2005-07-28

    申请号:US10508068

    申请日:2003-03-14

    摘要: The present invention provides methods for high throughput analysis of analytes in complex mixtures for unresolved chromatographic peaks including specific embodiment for summing intensities for each mass transition of interest over a selected chromatographic peak (50) to generate a signal corresponding to total intensity for each transition (55, 60). The intensities are deconvoluted into intensities of individual analytes (65, 70), based on branching ratios acquired from authentic standards, and a comparison to calibration curve is performed to obtain a quantitative concentration measurement of a particular analyte in a sample.

    摘要翻译: 本发明提供了用于未分辨色谱峰的复杂混合物中分析物的高通量分析的方法,包括用于在所选择的色谱峰(50)上对每个感兴趣的质量转换求和强度的特定实施方案,以产生对应于每个转变的总强度的信号 55,60)。 基于从真实标准获得的分支比例,将强度解卷积成单个分析物(65,70)的强度,并且进行与校准曲线的比较以获得样品中特定分析物的定量浓度测量。

    Synchronous twin reciprocating piston apparatus
    2.
    发明授权
    Synchronous twin reciprocating piston apparatus 失效
    同步双向往复活塞装置

    公开(公告)号:US5693991A

    公开(公告)日:1997-12-02

    申请号:US599206

    申请日:1996-02-09

    摘要: A synchronous twin reciprocating piston apparatus includes a cylinder and a number of stator assemblies mounted in fixed relation thereto. The stator assemblies are constructed so as to generate a radial magnetic field in a number of regions near to each end of the cylinder. The apparatus also includes a pair of piston-magnet assemblies, each having a piston slidable within an end of the cylinder, and a number of compound permanent magnet systems located within the regions. Each compound permanent magnet system includes a first section magnetized in a direction radial relative to the cylinder axis and a second section, axially displaced from the first, magnetized in the opposite direction. When the stator assemblies are excited with an alternating current, the piston-magnet assemblies reciprocate axially relative to said cylinder, and synchronously with the frequency of the applied current. The pistons then generate a pulsating pressure within the cylinder.

    摘要翻译: 同步双向往复活塞装置包括一个与其固定关系安装的气缸和多个定子组件。 定子组件被构造成在靠近气缸两端的多个区域中产生径向磁场。 该装置还包括一对活塞 - 磁体组件,每个活塞 - 磁体组件都具有可在气缸的端部内滑动的活塞和位于该区域内的多个复合永磁体系统。 每个复合永磁体系统包括在相对于气缸轴线径向的方向上被磁化的第一部分和从第一部分沿相反方向被磁化的第二部分。 当定子组件被交流电激励时,活塞 - 磁体组件相对于所述气缸轴向往复运动,并与施加电流的频率同步。 活塞然后在气缸内产生脉动压力。

    Method of analyzing dicarboxylic acids
    3.
    发明授权
    Method of analyzing dicarboxylic acids 有权
    二羧酸分析方法

    公开(公告)号:US06692971B2

    公开(公告)日:2004-02-17

    申请号:US09835845

    申请日:2001-04-17

    IPC分类号: G01N2400

    摘要: A novel method for the qualitative and quantitative analysis of dicarboxylic acids in biological samples is provided. The method includes the steps of esterfying the acid component of the sample and subsequently analyzing the esterified sample using tandem mass spectroscopy using atmospheric pressure ionization techniques in the positive ion mode. The method is particularly useful in the determination of methylmalonic acid in biological samples, and thus, the diagnosis of vitamin B12 deficiency.

    摘要翻译: 提供了一种用于定性和定量分析生物样品中二羧酸的新方法。 该方法包括以下步骤:酯化样品的酸组分,然后使用串联质谱法利用正离子模式中的大气压电离技术分析酯化样品。 该方法特别适用于生物样品中甲基丙二酸的测定,从而诊断维生素B12缺乏症。

    SIP SERVER OVERLOAD DETECTION AND CONTROL
    5.
    发明申请
    SIP SERVER OVERLOAD DETECTION AND CONTROL 有权
    SIP服务器过载检测与控制

    公开(公告)号:US20100103818A1

    公开(公告)日:2010-04-29

    申请号:US12259011

    申请日:2008-10-27

    IPC分类号: H04L1/00

    摘要: The current invention is related to a system and a method for session overload protocol (SIP) server overload detection and control. The current invention proceeds by receiving SIP messages at the SIP server from a communications network; processing the received SIP messages; detecting an overload based on a trigger condition as a result of receiving and processing SIP messages; and transitioning the SIP server to an overload state and applying appropriate control actions to mitigate the detected overload.

    摘要翻译: 本发明涉及一种用于会话过载协议(SIP)服务器过载检测和控制的系统和方法。 本发明通过在SIP服务器处从通信网络接收SIP消息来进行; 处理接收到的SIP消息; 作为接收和处理SIP消息的结果,基于触发条件检测过载; 并将SIP服务器转换到过载状态,并应用适当的控制动作来减轻检测到的过载。

    Displacer assembly for Stirling cycle system
    6.
    发明授权
    Displacer assembly for Stirling cycle system 失效
    用于斯特林循环系统的位移组件

    公开(公告)号:US5907201A

    公开(公告)日:1999-05-25

    申请号:US980623

    申请日:1997-12-01

    摘要: A displacer assembly for a Stirling cycle system includes a displacer and a synchronous linear electric motor linked so as to drive the displacer. The electric motor features at least one stator assembly having first and second soft-magnetic pole pieces defining therebetween a gap. The width of the gap is oriented perpendicular to an axis of movement of the motor, and the stator assembly is constructed so as to generate a magnetic field aligned primarily parallel to the width of the gap. The motor also includes at least one compound permanent magnet system located within the gap. The compound permanent magnet system has a first section magnetized in a first direction parallel to the width of the gap and a second section axially displaced from the first section magnetized in a direction opposite to the first direction. The result of this structure is that the electric motor operates as a magnetic spring which, when no power is supplied to the motor, returns the displacer to a predefined rest position.

    摘要翻译: 用于斯特林循环系统的置换器组件包括置换器和连接以驱动置换器的同步线性电动机。 电动机具有至少一个定子组件,其具有在其间限定间隙的第一和第二软磁极片。 间隙的宽度垂直于电动机的运动轴线定向,并且定子组件被构造成产生主要与间隙的宽度平行排列的磁场。 电动机还包括位于间隙内的至少一个复合永磁体系统。 复合永磁体系具有沿平行于间隙的宽度的第一方向磁化的第一部分和从与第一方向相反的方向被磁化的第一部分轴向移位的第二部分。 这种结构的结果是,电动机作为磁性弹簧工作,当没有电力供应到电动机时,将置换器返回到预定的静止位置。

    Split sterling cryogenic cooler
    7.
    发明授权
    Split sterling cryogenic cooler 失效
    分体式低温冷却器

    公开(公告)号:US4862695A

    公开(公告)日:1989-09-05

    申请号:US116469

    申请日:1987-11-03

    申请人: Mark Kushnir

    发明人: Mark Kushnir

    IPC分类号: F02G1/043 F02G1/044 F25B9/14

    摘要: A split Stirling cryogenic cooler including a compressor located in a first unit, and, located in a second unit, an expander-displacer defining an expansion volume, a cold tip adjacent the expansion volume, a regenerator heat exchanger and a displacer, a pneumatic conduit coupled the first unit to the second unit whereby pressurized gas pulses are provided from the compressor to the displacer for driving therof in oscillatory motion and apparatus for providing controllable damping of the resonant motion of the displacer comprising pneumatic flow produced friction damping apparatus.

    摘要翻译: 一种分体式斯特林低温冷却器,包括位于第一单元中的压缩机,并且位于第二单元中,限定膨胀容积的膨胀器置换器,与膨胀容积相邻的冷尖端,再生器热交换器和置换器,气动管道 将第一单元耦合到第二单元,由此从压缩机向移位器提供加压气体脉冲以驱动振荡运动,以及用于提供包括气动产生的摩擦阻尼装置的置换器的共振运动的可控阻尼的装置。

    SIP server overload detection and control
    8.
    发明授权
    SIP server overload detection and control 有权
    SIP服务器过载检测和控制

    公开(公告)号:US07869364B2

    公开(公告)日:2011-01-11

    申请号:US12259011

    申请日:2008-10-27

    IPC分类号: G01R31/08

    摘要: The current invention is related to a system and a method for session overload protocol (SIP) server overload detection and control. The current invention proceeds by receiving SIP messages at the SIP server from a communications network; processing the received SIP messages; detecting an overload based on a trigger condition as a result of receiving and processing SIP messages; and transitioning the SIP server to an overload state and applying appropriate control actions to mitigate the detected overload.

    摘要翻译: 本发明涉及一种用于会话过载协议(SIP)服务器过载检测和控制的系统和方法。 本发明通过在SIP服务器处从通信网络接收SIP消息来进行; 处理接收到的SIP消息; 作为接收和处理SIP消息的结果,基于触发条件检测过载; 并将SIP服务器转换到过载状态,并应用适当的控制动作来减轻检测到的过载。

    Piston-cylinder assembly particularly useful in stirling cycle machines
    9.
    发明授权
    Piston-cylinder assembly particularly useful in stirling cycle machines 失效
    活塞式气缸组件特别适用于搅拌循环机

    公开(公告)号:US5195320A

    公开(公告)日:1993-03-23

    申请号:US794089

    申请日:1991-11-18

    申请人: Mark Kushnir

    发明人: Mark Kushnir

    IPC分类号: F02G1/043 F25B9/14

    摘要: A piston-cylinder assembly in which the piston includes two piston heads connected together in spaced relation by a stem and cooperable with two portions of the cylinder, dividing the cylinder into a working chamber on one side of the first piston head between it and the end wall of the cylinder, a drive chamber on the opposite side of the second piston head communicating with the drive, and an intermediate chamber between the working chamber and drive chamber. The first piston head defines a clearance seal with respect to the first portion of the cylinder, and the second portion of the cylinder guides the reciprocatory movements of the piston. The intermediate chamber includes a semi-permeable seal between the cylinder and piston, which seal is permeable by gas but impermeable by liquids, to thereby prevent the passage of liquid from the drive chamber through the intermediate chamber to the working chamber.

    摘要翻译: 一种活塞 - 气缸组件,其中活塞包括两个活塞头,两个活塞头由阀杆间隔开连接在一起,并与汽缸的两个部分配合,将汽缸分为工作室,第一活塞头的一侧和末端之间 气缸的壁,位于与驱动器连通的第二活塞头的相对侧上的驱动室,以及在工作室和驱动室之间的中间室。 第一活塞头相对于气缸的第一部分限定间隙密封,并且气缸的第二部分引导活塞的往复运动。 中间室包括在气缸和活塞之间的半透性密封件,该密封件由气体渗透但不被液体渗透,从而防止液体从驱动室通过中间室到达工作室。

    Seal compressor
    10.
    发明授权
    Seal compressor 失效
    密封压缩机

    公开(公告)号:US5046929A

    公开(公告)日:1991-09-10

    申请号:US336059

    申请日:1989-04-11

    CPC分类号: F04B39/047

    摘要: A piston-type compressor includes a cylinder having a liner sleeve in which is mounted a reciprocating piston driven by a crankshaft through a connecting rod. The piston forms a dynamic seal with the sleeve with the volume above the piston head defining a first, or compression chamber. Connected between the piston and the compressor cylinder is a flexible sealing element such as a bellows which defines a second, isolating chamber between the bellows and the dynamic seal and which further defines a third, or crankcase chamber between the bellows and the region of the compressor which includes the crankcase. The volumes in the second and third chambers are chosen so that the pressures therein are generally equal. A bypass filter assists in eliminating the pressure differential across the bellows during startup by maintaining the pressure within the intermediate and crankcase chambers substantially equal. The bellows and bypass filter cooperate to prevent contamination from the crankcase from reaching the isolating chamber or the compression chamber.

    摘要翻译: 活塞式压缩机包括具有衬套的气缸,其中安装有由曲轴通过连杆驱动的往复活塞。 活塞与套筒形成动态密封,活塞头上方的体积限定第一或压缩室。 连接在活塞和压缩机气缸之间的是柔性密封元件,例如波纹管,其在波纹管和动态密封件之间限定第二隔离室,并且还在波纹管和压缩机的区域之间限定第三或曲轴箱室 其中包括曲轴箱。 选择第二和第三室中的体积,使得其中的压力大致相等。 旁路过滤器通过保持中间和曲轴箱内部的压力基本相等而有助于消除启动过程中波纹管两端的压差。 波纹管和旁路过滤器配合,以防止曲轴箱的污染物到达隔离室或压缩室。