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公开(公告)号：US20090170886A1
公开(公告)日：2009-07-02
申请号：US11997983
申请日：2006-07-07
申请人： Mark Laurence Boys , Michelle Marie Bruendl , Victoria Leigh Downs , Stephen Alan Fakhoury , William Glen Harter , Lain-Yen Hu , Sandra Marie Jennings , Bruce Allen Lefker , Lorna Helen Mitchell , Raj Kumar Raheja , Yvonne Dorothy Smith
发明人： Mark Laurence Boys , Michelle Marie Bruendl , Victoria Leigh Downs , Stephen Alan Fakhoury , William Glen Harter , Lain-Yen Hu , Sandra Marie Jennings , Bruce Allen Lefker , Lorna Helen Mitchell , Raj Kumar Raheja , Yvonne Dorothy Smith
IPC分类号： A61K31/435 , C07C43/20 , C07D213/02 , A61P35/00 , A61K31/08
CPC分类号： C07C255/54 , C07C2601/02 , C07D213/30 , C07D213/64 , C07D213/65 , C07D309/12 , C07D319/20
摘要： The present invention is directed to a new class of benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的苯腈和它们作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US20090105349A1
公开(公告)日：2009-04-23
申请号：US11572760
申请日：2005-08-08
申请人： Nicole Chantel Barvian , Daniel Yunlong Du , Lain-Yen Hu , Donna Michele Iula , Bruce Allen Lefker , Huangshu Lei , Raj Kumar Raheja , Yvonne Dorothy Smith
发明人： Nicole Chantel Barvian , Daniel Yunlong Du , Lain-Yen Hu , Donna Michele Iula , Bruce Allen Lefker , Huangshu Lei , Raj Kumar Raheja , Yvonne Dorothy Smith
IPC分类号： A61K31/135 , A61P5/26
CPC分类号： A61K31/275
摘要： The present invention is directed to the discovery of a new class of androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease sebum secretion and to stimulate hair growth.
摘要翻译： 本发明涉及新型雄激素受体调节剂的发现。 本发明的其它方面涉及这些化合物减少皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07670613B2
公开(公告)日：2010-03-02
申请号：US11175097
申请日：2005-07-05
申请人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
发明人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
IPC分类号： A61K9/00
CPC分类号： C07C255/54 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-环烷氧基苯并腈及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US20100048517A1
公开(公告)日：2010-02-25
申请号：US12546103
申请日：2009-11-05
申请人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
发明人： Lain-Yen Hu , Bruce A. Lefker , Daniel Y. Du , Yvonne Dorothy Smith , Huangshu Lei , William Glen Harter , Victoria Leigh Downs , Mark L. Boys , Donna Michele Iula
IPC分类号： A61K31/655 , C07C255/00
CPC分类号： C07C255/54 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention is directed to a new class of 4-cycloalkoxy benzonitriles and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-环烷氧基苯并腈及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US20090192202A1
公开(公告)日：2009-07-30
申请号：US12367887
申请日：2009-02-09
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： A61K31/165 , C07C237/20 , C07D213/57 , A61K31/44 , A61P17/00
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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公开(公告)号：US07507860B2
公开(公告)日：2009-03-24
申请号：US10599143
申请日：2005-04-01
申请人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
发明人： Lain-Yen Hu , Huangshu Lei , Daniel Y. Du , Bruce A. Lefker , Yvonne Dorothy Smith , Victor Fedij
IPC分类号： C07C211/08
CPC分类号： C07C255/54 , C07C323/41 , C07C2601/02 , C07C2602/08 , C07D209/16 , C07D213/40 , C07D285/01 , C07D307/52 , C07D307/81 , C07D311/76 , C07D317/58 , C07D333/20 , C07D471/04
摘要： The present invention is directed to a new class of 4-cyano-phenoxy-alkyl carboxyl derivatives and to their use as androgen receptor modulators. Other aspects of the invention are directed to the use of these compounds to decrease excess sebum secretions and to stimulate hair growth.
摘要翻译： 本发明涉及一类新的4-氰基 - 苯氧基 - 烷基羧基衍生物及其作为雄激素受体调节剂的用途。 本发明的其它方面涉及这些化合物用于减少过量的皮脂分泌和刺激毛发生长的用途。
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