摘要:
Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited by the generation of a HAMA response. The present invention discloses humanized 1G8 antibodies in which the majority of the mouse-derived epitopes have been removed. These humanized antibodies bind PSCA with high affinity and specificity, and have been shown to reduce human bladder tumor take in a nude mouse model. These characteristics make the humanized antibodies of the present invention attractive agents for the treatment and detection of tumors expressing PSCA.
摘要:
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.
摘要:
Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framework having maximum structural overlap with a non-human donor molecule. This technique was used to develop humanized T84.66 antibodies exhibiting in vitro binding affinity and specificity for carcinoembryonic antigen (CEA) nearly identical to that of T84.66 and the ability to specifically target tumors expressing CEA in vivo.
摘要:
An operation of drilling an earth borehole uses a drilling rig, a drill string of drill pipes having its generally upper end mechanically coupleable with and suspendable from the drilling rig, a drive string portion of the drill string, mechanically coupleable with the topmost drill pipe of said drill string, and a drive mechanism mechanically coupleable with the drive string for rotating the drive string and the drill string. A system for generating electric power in the region of the drive string includes an electric generator, which includes a rotating generator component mounted on said drive string for rotation therewith and a stationary generator component mounted on a stationary portion of the drilling rig. The rotating generator component produces electric power in the region of the drive string.
摘要:
The invention relates to pliable surgical implants manufactured of bioabsorbable (or biodegradable) polymer, copolymer, polymer alloy or composite and used for fixation of a bone block (graft) into a drillhole in a bone.
摘要:
A drilling system comprises a drillstring including a dill bit, a bottomhole assembly coupled to the drill bit, and a plurality of interconnected tubular members coupled to the bottomhole assembly. A first tubular member includes a communication link having a first annular inductive coupler element disposed in an annular recess in a first end, a second annular inductive coupler element disposed in an annular recess in a second end, and a cable coupling the first annular inductive coupler element to the second annular inductive coupler element. In addition, the drilling system comprises a first signal level determination unit disposed in the drillstring and configured to determine a level of a first signal communicated from the second inductive coupler element. Further, the drilling system comprises an axial load determination unit configured to determine an axial load at the first signal level determination unit based on the level of the first signal.
摘要:
A drilling system comprises a drillstring including a dill bit, a bottomhole assembly coupled to the drill bit, and a plurality of interconnected tubular members coupled to the bottomhole assembly. A first tubular member includes a communication link having a first annular inductive coupler element disposed in an annular recess in a first end, a second annular inductive coupler element disposed in an annular recess in a second end, and a cable coupling the first annular inductive coupler element to the second annular inductive coupler element. In addition, the drilling system comprises a first signal level determination unit disposed in the drillstring and configured to determine a level of a first signal communicated from the second inductive coupler element. Further, the drilling system comprises an axial load determination unit configured to determine an axial load at the first signal level determination unit based on the level of the first signal.
摘要:
A method for measuring and reducing the cost of complexity in producing products or providing a service by comparing selected non-value added steps in the manufacturing or service process with the number of different products or services provided, so as to provide the non-value added cost of the product or service for various selected complexities. The number of products required to be processed or held in inventory for a particular demand, or the number of different specific services required for a particular demand of the service is determined by comparing the number of different product part numbers, or service categories offered, with selected non-value added steps in the respective processes. Mathematical analyses are derived from equations of motion of process improvement including the first derivative of process velocity.