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公开(公告)号:US09359605B2
公开(公告)日:2016-06-07
申请号:US14004416
申请日:2012-03-12
IPC分类号: A61K48/00 , C07H21/02 , C07H21/04 , C12N15/113 , A61K31/7088 , A61K31/7105 , A61K31/7115
CPC分类号: C12N15/1135 , A61K31/198 , A61K31/282 , A61K31/502 , A61K31/513 , A61K31/7088 , A61K31/7105 , A61K31/7115 , A61K31/713 , A61K33/24 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/341 , C12N2310/346 , C12N2320/31 , C12Y201/01045 , C12N2310/3521 , C12N2310/3525 , A61K2300/00
摘要: Methods of treating cancer using antisense oligonucleotides directed against DNA double-strand break repair proteins such as BRCA2 or RAD51 are provided. The antisense oligonucleotides can be used alone, in tandem or in combination with other cancer therapies, in particular with therapies that lead to DNA damage, inhibition of DNA repair or inhibition of DNA synthesis, such as radiation, platinum drugs, alkylating agents, PARP inhibitors, or inhibitors of thymidylate synthase.
摘要翻译: 提供了使用针对DNA双链断裂修复蛋白(例如BRCA2或RAD51)的反义寡核苷酸治疗癌症的方法。 反义寡核苷酸可以单独使用或与其他癌症治疗组合使用,特别是与导致DNA损伤,DNA修复抑制或DNA合成抑制的疗法,如放射线剂,铂药物,烷化剂,PARP抑制剂 ,或胸苷酸合酶抑制剂。
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公开(公告)号:US09781776B2
公开(公告)日:2017-10-03
申请号:US14739783
申请日:2015-06-15
申请人: Mark Vincent , Mark Palmer
发明人: Mark Vincent , Mark Palmer
CPC分类号: H05B6/367 , B22D35/04 , C21B7/14 , C21D1/10 , F27D1/0006 , F27D3/145 , F27D11/02 , F27D99/0006 , F27D2099/0015 , H05B6/18 , Y02P10/253
摘要: Disclosed is a heating system for molten metal handling devices, examples of which are troughs, launders and other vessels. The heating system may include a refractory containment body, heater assembly, a containment shell and a thermal inducing interface between the heater assemblies and the containment shell and/or refractory body.
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公开(公告)号:US09248497B2
公开(公告)日:2016-02-02
申请号:US14006457
申请日:2012-06-18
申请人: Mark Vincent
发明人: Mark Vincent
CPC分类号: B22D35/04 , B22D41/01 , B22D41/02 , F27D1/0006 , F27D3/145
摘要: A metal transfer device (1) includes a cast trough body (2) for receiving liquid metal, a heater (4) for heating the trough body, and a filler layer (6) between the trough body and the heater. The filler layer (6) comprises a cast refractory material having a high thermal conductivity.
摘要翻译: 金属转移装置(1)包括用于接收液体金属的浇注槽体(2),用于加热槽体的加热器(4)和在槽体和加热器之间的填充层(6)。 填料层(6)包括具有高导热性的铸造耐火材料。
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公开(公告)号:US20100308288A1
公开(公告)日:2010-12-09
申请号:US12682229
申请日:2008-10-06
申请人: Mark Vincent
发明人: Mark Vincent
IPC分类号: B66F3/00
CPC分类号: C22B9/023 , C22B21/066 , F16B23/0084 , F16B25/103 , F16B2037/007 , Y02P10/234
摘要: An extraction device is provided for use when extracting a ceramic foam filter, as used for example in the production and processing of aluminium. The extraction device includes an anchor device (3) suitable for driving into the filter, said anchor device (3) having an anchor body (5) with a leading end and a trailing end, a screw thread (13) for engagement with the filter and a substantially pointed part (7) at the leading end for piercing a surface of the filter.
摘要翻译: 提取提取装置用于提取陶瓷泡沫过滤器时,例如用于生产和加工铝。 提取装置包括适于驱动到过滤器中的锚定装置(3),所述锚固装置(3)具有带有前端和后端的锚固体(5),用于与过滤器接合的螺纹(13) 以及在前端的基本上尖的部分(7),用于刺穿过滤器的表面。
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公开(公告)号:US20100109210A1
公开(公告)日:2010-05-06
申请号:US12290735
申请日:2008-11-03
申请人: Mark Vincent
发明人: Mark Vincent
IPC分类号: B22D41/02
摘要: A molten metal handling device comprising an outer shell defined by a bottom and two side walls, an insulating layer partially filling the outer shell and a thermally conductive castable refractory body for carrying molten metal, the refractory body being within the insulating layer. The device further includes at least one heating element positioned in the insulating layer, adjacent to the refractory body,. The refractory body is preferably fabricated from a castable alumina or castable silicon carbide material.
摘要翻译: 一种熔融金属处理装置,包括由底部和两个侧壁限定的外壳,部分填充外壳的绝缘层和用于承载熔融金属的导热浇注耐火体,所述耐火体位于所述绝缘层内。 该装置还包括位于绝缘层中的至少一个加热元件,邻近耐火材料体。 耐火体优选由可浇铸的氧化铝或可浇铸的碳化硅材料制成。
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公开(公告)号:US20050077661A1
公开(公告)日:2005-04-14
申请号:US10944340
申请日:2004-09-17
申请人: Mark Vincent
发明人: Mark Vincent
摘要: A casting ladle has a body (2) with a base (3) and walls (4, 6, 8) made of a laminated composite ceramic material that includes multiple layers of a woven fiber reinforcing fabric embedded in a ceramic matrix. A rigid support element (20) for attaching the ladle to a handling device is embedded within the composite ceramic material. In a preferred form, the reinforcing fabric is made of woven glass and the matrix material includes calcium silicate and silica.
摘要翻译: 铸造钢包具有带有基部(3)的主体(2)和由层压复合陶瓷材料制成的壁(4,6,8),其包括嵌入陶瓷基体中的多层织造纤维增强织物。 用于将钢包连接到处理装置的刚性支撑元件(20)嵌入在复合陶瓷材料内。 在优选形式中,增强织物由机织玻璃制成,并且基质材料包括硅酸钙和二氧化硅。
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公开(公告)号:US09095896B2
公开(公告)日:2015-08-04
申请号:US12290735
申请日:2008-11-03
申请人: Mark Vincent
发明人: Mark Vincent
摘要: A molten metal handling device comprising an outer shell defined by a bottom and two side walls, an insulating layer partially filling the outer shell and a thermally conductive castable refractory body for carrying molten metal, the refractory body being within the insulating layer. The device further includes at least one heating element positioned in the insulating layer, adjacent to the refractory body. The refractory body is preferably fabricated from a castable alumina or castable silicon carbide material.
摘要翻译: 一种熔融金属处理装置,包括由底部和两个侧壁限定的外壳,部分填充外壳的绝缘层和用于承载熔融金属的导热浇注耐火体,所述耐火体位于所述绝缘层内。 该装置还包括位于绝缘层中的至少一个加热元件,邻近耐火材料体。 耐火体优选由可浇铸的氧化铝或可浇铸的碳化硅材料制成。
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公开(公告)号:US20140008399A1
公开(公告)日:2014-01-09
申请号:US14006457
申请日:2012-06-18
申请人: Mark Vincent
发明人: Mark Vincent
IPC分类号: B22D35/04
CPC分类号: B22D35/04 , B22D41/01 , B22D41/02 , F27D1/0006 , F27D3/145
摘要: A metal transfer device (1) includes a cast trough body (2) for receiving liquid metal, a heater (4) for heating the trough body, and a filler layer (6) between the trough body and the heater. The filler layer (6) comprises a cast refractory material having a high thermal conductivity.
摘要翻译: 金属转移装置(1)包括用于接收液体金属的浇注槽体(2),用于加热槽体的加热器(4)和在槽体和加热器之间的填充层(6)。 填料层(6)包括具有高导热性的铸造耐火材料。
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公开(公告)号:US07731502B2
公开(公告)日:2010-06-08
申请号:US12409114
申请日:2009-03-23
申请人: Dave Cummings , Michael O'Reilly , Neal Pugh , Mark Vincent
发明人: Dave Cummings , Michael O'Reilly , Neal Pugh , Mark Vincent
IPC分类号: H01R33/00
CPC分类号: H01R13/745 , H01R13/5213
摘要: An electrical connector including a first connector portion and a second connector portion. First and second covers are pivotally attached to the body about a common axis for covering the first and second connector portion.
摘要翻译: 一种电连接器,包括第一连接器部分和第二连接器部分。 第一和第二盖围绕公共轴枢转地附接到主体以覆盖第一和第二连接器部分。
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公开(公告)号:US20090181555A1
公开(公告)日:2009-07-16
申请号:US12409114
申请日:2009-03-23
申请人: Dave Cummings , Michael O'Reilly , Neal Pugh , Mark Vincent
发明人: Dave Cummings , Michael O'Reilly , Neal Pugh , Mark Vincent
IPC分类号: H01R33/00
CPC分类号: H01R13/745 , H01R13/5213
摘要: An electrical connector including a first connector portion and a second connector portion. First and second covers are pivotally attached to the body about a common axis for covering the first and second connector portion.
摘要翻译: 一种电连接器,包括第一连接器部分和第二连接器部分。 第一和第二盖围绕公共轴枢转地附接到主体以覆盖第一和第二连接器部分。
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