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公开(公告)号：US20070259925A1
公开(公告)日：2007-11-08
申请号：US11778796
申请日：2007-07-17
申请人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Loeffler , Ramakanth Sarabu , Hans Peter Wessel
发明人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Loeffler , Ramakanth Sarabu , Hans Peter Wessel
IPC分类号： A61K31/426 , A61K31/40 , A61K31/4439 , A61P3/00 , A61P3/10 , C07D231/10 , C07D277/20 , C07D403/02 , C07D413/02 , C07D401/02 , C07D263/02 , C07D207/04 , A61P3/04 , A61P1/00 , A61K31/421
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及其中R 1，R 2和X如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与DPP IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量异常。
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公开(公告)号：US06861440B2
公开(公告)日：2005-03-01
申请号：US10269519
申请日：2002-10-14
申请人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
发明人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
IPC分类号： A61K20060101 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5355 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , C07D20060101 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及其中R 1，R 2和X如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与DPP IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量异常。
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公开(公告)号：US07803819B2
公开(公告)日：2010-09-28
申请号：US11778796
申请日：2007-07-17
申请人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
发明人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
IPC分类号： A61K31/44 , C07D401/04 , C07D401/14
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2和X如说明书和权利要求中所定义，及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与DPP IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量异常。
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公开(公告)号：US07314884B2
公开(公告)日：2008-01-01
申请号：US11010899
申请日：2004-12-13
申请人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
发明人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Michael Loeffler , Ramakanth Sarabu , Hans Peter Wessel
IPC分类号： A61K31/422 , C07D405/12
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及其中R 1，R 2和X如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与DPP IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量异常。
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公开(公告)号：US20050096348A1
公开(公告)日：2005-05-05
申请号：US11010899
申请日：2004-12-13
申请人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Loeffler , Ramakanth Sarabu , Hans Wessel
发明人： Markus Boehringer , Daniel Hunziker , Holger Kuehne , Bernd Loeffler , Ramakanth Sarabu , Hans Wessel
IPC分类号： A61K20060101 , A61K31/40 , A61K31/401 , A61K31/4025 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4155 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/454 , A61K31/4709 , A61K31/497 , A61K31/506 , A61K31/5355 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , C07D20060101 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04 , C07D41/02 , A61K31/426
CPC分类号： C07D277/06 , A61K9/0019 , A61K9/1623 , A61K9/2853 , A61K9/2866 , A61K9/4825 , A61K9/4858 , A61K9/4875 , C07D207/16 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： The present invention relates to compounds of formula (I) wherein R1, R2, and X are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
摘要翻译： 本发明涉及其中R 1，R 2和X如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 所述化合物可用于治疗和/或预防与DPP IV相关的疾病，例如糖尿病，特别是非胰岛素依赖性糖尿病和葡萄糖耐量异常。
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![Substituted thiazolo[5,4-d]pyrimidine urea derivatives](/abs-image/US/2011/05/24/US07947692B2/abs.jpg.150x150.jpg)
公开(公告)号：US07947692B2
公开(公告)日：2011-05-24
申请号：US11801972
申请日：2007-05-11
申请人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
发明人： John A. Brinkman , Adrian Wai-Hing Cheung , Fariborz Firooznia , Kevin Richard Guertin , Nicholas Marcopulos , Lida Qi , Jagdish Kumar Racha , Ramakanth Sarabu , Jenny Tan , Jefferson Wright Tilley
IPC分类号： C07D487/04 , C07D513/04 , A61K31/519 , A61P3/10 , A61P11/06 , A61K31/4353 , A61K31/496 , A61K31/5355 , A61K31/45
CPC分类号： C07D513/04 , C07D521/00
摘要： There are presented compounds of the formula or a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.
摘要翻译： 呈现下式的化合物或其药学上可接受的盐，它们是活性腺苷A2B受体拮抗剂，可用于治疗糖尿病，糖尿病性视网膜病变，哮喘和腹泻。
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7.发明授权公开(公告)号：US07259166B2
公开(公告)日：2007-08-21
申请号：US11402167
申请日：2006-04-10
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
IPC分类号： C07D241/20 , C07D213/75 , C07D277/46 , C07D409/12
CPC分类号： C07D213/75 , C07C275/50 , C07C2601/08 , C07D241/20 , C07D277/46 , C07D307/16 , C07D309/04 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
摘要翻译： 2,3-二取代的N-杂芳族丙酰胺，其中2-取代为取代苯基，3-位是极性环，所述丙酰胺是葡萄糖激酶活化剂，其在II型治疗中增加胰岛素分泌 糖尿病。
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公开(公告)号：US07105671B2
公开(公告)日：2006-09-12
申请号：US10421109
申请日：2003-04-23
申请人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
发明人： Wendy Lea Corbett , Joseph Samuel Grimsby , Nancy-Ellen Haynes , Robert Francis Kester , Paige Erin Mahaney , Jagdish Kumar Racha , Ramakanth Sarabu , Ka Wang
IPC分类号： C07D241/20 , C07D213/75 , C07D277/46 , C07D409/12
CPC分类号： C07D213/75 , C07C275/50 , C07C2601/08 , C07D241/20 , C07D277/46 , C07D307/16 , C07D309/04 , C07D405/12 , C07D409/12 , C07D417/12
摘要： 2,3-Di-substituted N-heteroaromatic propionamides with said substitution at the 2-position being a substituted phenyl group and at the 3-position being a polar ring, said propionamides being glucokinase activators which increase insulin secretion in the treatment of type II diabetes.
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9.发明授权&agr;-acyl- and &agr;-heteroatom-substituted benzene acetamide glucokinase activators 失效α-酰基和α-杂原子取代的苯乙酰胺葡萄糖激酶激活剂公开(公告)号：US06608218B2
公开(公告)日：2003-08-19
申请号：US10179717
申请日：2002-06-25
IPC分类号： C07D30902
CPC分类号： C07D213/75 , C07C275/50 , C07C317/46 , C07C2601/08 , C07C2601/16 , C07D277/18 , C07D277/46 , C07D309/12 , C07D417/12
摘要： Substituted benzene acetamide compounds and pharmaceutically acceptable salts thereof are useful as glucokinase activators.
摘要翻译： 取代的苯乙酰胺化合物及其药学上可接受的盐可用作葡糖激酶活化剂。
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公开(公告)号：US06384220B2
公开(公告)日：2002-05-07
申请号：US09846821
申请日：2001-05-01
IPC分类号： C07D26530
CPC分类号： C07D213/75 , C07C317/44 , C07C2601/08 , C07C2601/14 , C07D209/18 , C07D213/56 , C07D213/80 , C07D277/46 , C07D277/56 , C07D295/155 , C07D417/12
摘要： Para-aryl or heteroaryl substituted phenyl amides which are active as glucokinase activators to increase insulin secretion which makes them useful for treating type II diabetes.
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