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    Diagnostic Transcript and Splice Patterns of HPV16 in Different Cervical Lesions
    3.
    发明申请
    Diagnostic Transcript and Splice Patterns of HPV16 in Different Cervical Lesions 有权
    HPV16在不同宫颈病变中的诊断睾丸和融合模式

    公开(公告)号：US20120040334A1

    公开(公告)日：2012-02-16

    申请号：US13128201

    申请日：2009-11-09

    申请人： Markus Schmitt ,  Lutz Gissmann ,  Michael Pawlita

    发明人： Markus Schmitt ,  Lutz Gissmann ,  Michael Pawlita

    IPC分类号： C12Q1/70 ,  C12M1/34

    CPC分类号： C12Q1/708 ,  C12Q2545/113

    摘要： The present invention relates to a method for differentiating in a subject with HPV16 between (i) a severe form of HPV16 infection and (ii) a mild form of HPV16 infection based on determining the amount of a first gene product and a second gene product in a sample of a subject and calculating a ratio of the amount of said first gene product and the amount of said second gene product. Further envisaged by the present invention is a composition comprising an oligonucleotide mixture. Also envisaged by the present invention are a kit and a device adapted to carry out the method of the present invention.

    摘要翻译： 本发明涉及一种用于在（i）严重形式的HPV16感染和（ii）轻度形式的HPV16感染之间的HPV16差异化的方法，其基于确定第一基因产物和第二基因产物的量 计算受试者的样品并计算所述第一基因产物的量与所述第二基因产物的量的比率。 本发明进一步设想的是包含寡核苷酸混合物的组合物。 本发明还设想了适用于实施本发明方法的试剂盒和装置。

    ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM
    5.
    发明申请
    ENHANCED PRODUCTION OF PAPILLOMAVIRUS-LIKE PARTICLES WITH A MODIFIED BACULOVIRUS EXPRESSION SYSTEM 审中-公开
    用改良的巴氏杆菌表达系统增强具有类似芽胞杆菌的颗粒的生产

    公开(公告)号：US20120115207A1

    公开(公告)日：2012-05-10

    申请号：US13257248

    申请日：2010-03-30

    申请人： Tilo Senger ,  Martin Muller ,  Lutz Gissmann

    发明人： Tilo Senger ,  Martin Muller ,  Lutz Gissmann

    IPC分类号： C12N7/02 ,  C12N15/85 ,  C12N5/10

    CPC分类号： C12N15/86 ,  A61K39/00 ,  A61K2039/5258 ,  C12N7/00 ,  C12N2710/14143 ,  C12N2710/20023

    摘要： The present invention is concerned with the provision of a method for manufacturing papillomavirus like particles (PV-VLP), comprising the steps of a) culturing a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises at least one polynucleotide encoding a PV L1 polypeptide, and b) obtaining VLPs from the host cell. Also proposed is a host cell lacking protease activity and comprising an expression vector, wherein said expression vector comprises a polynucleotide encoding at least one PV L1 polypeptide. Furthermore, a method for the manufacture of a pharmaceutical composition for the treatment or prevention of PV-related disease comprising the steps of manufacturing PV-VLPs and the further step of formulating the VLPs as a pharmaceutical composition is proposed as well as an expression vector comprising at least one polynucleotide encoding a PV L1 polypeptide but lacking a functional gene for a v-cath protease.

    摘要翻译： 本发明涉及制备乳头瘤病毒样颗粒（PV-VLP）的方法，其包括以下步骤：a）培养缺乏蛋白酶活性的宿主细胞并包含表达载体，其中所述表达载体包含至少一种多核苷酸 编码PV L1多肽，和b）从宿主细胞获得VLP。 还提出了缺乏蛋白酶活性并包含表达载体的宿主细胞，其中所述表达载体包含编码至少一种PV L1多肽的多核苷酸。 此外，提出了制备用于治疗或预防PV相关疾病的药物组合物的方法，其包括制备PV-VLP的步骤和配制作为药物组合物的VLP的进一步步骤以及包含 编码PV L1多肽的至少一种多核苷酸，但缺乏v-cath蛋白酶的功能基因。

    Production and applications for polyvalent vaccines against diseases caused by papilloma viruses
    7.
    发明授权
    Production and applications for polyvalent vaccines against diseases caused by papilloma viruses 失效
    针对乳头瘤病毒引起的疾病的多价疫苗的生产和应用

    公开(公告)号：US07354714B2

    公开(公告)日：2008-04-08

    申请号：US10778936

    申请日：2004-02-13

    申请人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

    发明人： Lutz Gissmann ,  Kai Pohlmeyer ,  Martin Müller

    IPC分类号： C12Q1/68

    CPC分类号： C07K16/084 ,  A61K39/12 ,  C12N2710/20034

    摘要： A vaccine against disease caused by papilloma viruses is described in certain embodiments, as well as certain vectors, obtainable by the following methods: (a) one or more expression vectors that contain the DNA code for a structural protein of papilloma viruses or a fragment thereof are injected into mammals, whereby in at least some of the expression vectors randomly generated heterologous sequences are inserted into the DNA code (b) serums are obtained from the mammals and these are tested for the presence of antibodies against particles of various papilloma virus types, and (c) using the serums tested, the structural protein gene clones are identified that code for a polyvalent vaccine, and (d) the vaccine is produced from them. Procedures for producing a vaccine is also described, together with its use for vaccination against diseases caused by papilloma viruses.

    摘要翻译： 在某些实施方案中描述了针对由乳头瘤病毒引起的疾病的疫苗，以及可通过以下方法获得的某些载体：（a）含有乳头状瘤病毒或其片段的结构蛋白的DNA编码的一种或多种表达载体 注射到哺乳动物中，由此在至少一些表达载体中随机产生的异源序列插入到DNA代码（b）中，从哺乳动物获得血清，并测试这些血清是否存在针对各种乳头状瘤病毒类型的颗粒的抗体， 和（c）使用测试的血清，鉴定编码多价疫苗的结构蛋白质基因克隆，和（d）从它们产生疫苗。 还描述了生产疫苗的程序，以及其用于针对由乳头瘤病毒引起的疾病的疫苗接种的用途。

    Seroreactive epitopes on proteins of human papillomavirus (HPV) 18
    8.
    发明授权
    Seroreactive epitopes on proteins of human papillomavirus (HPV) 18 失效
    人乳头状瘤病毒（HPV）蛋白质上的血清反应性表位18

    公开(公告)号：US06322794B1

    公开(公告)日：2001-11-27

    申请号：US08164768

    申请日：1993-12-10

    申请人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

    发明人： Conrad Bleul ,  Lutz Gissmann ,  Martin Müller

    IPC分类号： A61K3912

    CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2710/20022

    摘要： The invention relates to seroreactive epitopes on proteins of human papillomavirus HPV18. In addition, the invention relates to peptides which have amino-acid sequences which coincide in whole or in part with the sequences of the seroreactive epitopes, and to vaccines which contain such peptides.

    摘要翻译： 本发明涉及人乳头状瘤病毒HPV18蛋白质上的血清反应性表位。此外，本发明涉及具有全部或部分与血清反应性表位的序列重合的氨基酸序列的肽以及含有这些肽的疫苗。

    Antibodies specific for seroreactive regions on HPV 16 protein E1
    9.
    发明授权
    Antibodies specific for seroreactive regions on HPV 16 protein E1 失效
    针对HPV16蛋白E1上的血清反应性区域特异的抗体

    公开(公告)号：US06723317B2

    公开(公告)日：2004-04-20

    申请号：US10340783

    申请日：2003-01-13

    申请人： Martin Müller ,  Lutz Gissmann

    发明人： Martin Müller ,  Lutz Gissmann

    IPC分类号： A61K39395

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/084 ,  C12N2710/20022

    摘要： The invention relates to seroreactive regions on proteins E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.

    摘要翻译： 本发明涉及人乳头状瘤病毒（HPV）16的蛋白质E1和E2上的血清反应性区域。本申请还涉及含有含有血清反应性区域的肽的疫苗。 本发明同样包含用于诊断目的的组合物，其含有具有血清反应性区域的肽。

    Seroreactive regions on HPV 16-proteins E1 and E2
    10.
    发明授权
    Seroreactive regions on HPV 16-proteins E1 and E2 失效
    HPV16蛋白E1和E2上的血清活性区

    公开(公告)号：US06221577B1

    公开(公告)日：2001-04-24

    申请号：US08468337

    申请日：1995-06-06

    申请人： Martin Müller ,  Lutz Gissmann

    发明人： Martin Müller ,  Lutz Gissmann

    IPC分类号： C12Q170

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  C07K14/005 ,  C07K16/084 ,  C12N2710/20022

    摘要： The invention relates to seroreactive regions on protein E1 and E2 of human papillomavirus (HPV) 16. The application also relates to a vaccine which contains such peptides which contain the seroreactive regions. The invention likewise embraces compositions for diagnostic purposes which contain peptides with the seroreactive regions.

    摘要翻译： 本发明涉及人乳头瘤病毒（HPV）16蛋白E1和E2上的血清反应性区域。本申请还涉及含有含有血清反应性区域的肽的疫苗。 本发明同样包含用于诊断目的的组合物，其含有具有血清反应性区域的肽。