公开(公告)号：US20130287706A1

公开(公告)日：2013-10-31

申请号：US13991523

申请日：2011-12-05

Applicant: Marshall A. Hayward ,  Timo Schmidt

Inventor： Marshall A. Hayward ,  Timo Schmidt

IPC: A61K9/46

CPC classification number: A61K9/0007 ,  A61K31/663

Abstract: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

Abstract translation: 稳定的泡腾片，颗粒或粉末组合物，其不含有与起泡有机酸组分反应的赋形剂，其包含有效量的双膦酸盐骨吸收抑制剂，起泡有机酸组分，起泡基质组分; 其中所述组合物不含多元醇粘合剂和压片润滑剂; 干燥失重为0.25％（m / m）以下; 在5-20℃之间放置在3至8个液体盎司的水中时，其完全崩解时间不超过180秒; 并且所述二膦酸盐作为微粉化颗粒掺入或通过喷雾干燥并在2分钟内完全溶解在水中而不搅拌。

公开(公告)号：US09592195B2

公开(公告)日：2017-03-14

申请号：US13991523

申请日：2011-12-05

Applicant: Marshall A. Hayward ,  Timo Schmidt

Inventor： Marshall A. Hayward ,  Timo Schmidt

IPC: A61K9/46 ,  A61K31/683 ,  A61K31/663

CPC classification number: A61K9/0007 ,  A61K31/663

Abstract: A stable effervescent tablet, granule or powder composition free from excipients that may react with an effervescing organic acid component, comprising, an effective amount of a bisphosphonate bone resorption inhibitor, an effervescing organic acid component, an effervescing base component; wherein said composition is free of polyol binders and tableting lubricants; has a loss on drying of 0.25% (m/m) or less; has a complete disintegration time of no more than 180 seconds when placed in 3 to 8 fluid ounces of water at between 5-20° C.; and said bisphosphonate is incorporated as a micronized particle or by spray drying and is completely solubdised in water within 2 minutes without stirring.

Abstract translation: 稳定的起泡片，颗粒或粉末组合物，其不含可能与起泡有机酸组分反应的赋形剂，其包含有效量的双膦酸盐骨吸收抑制剂，起泡有机酸组分，起泡基质组分; 其中所述组合物不含多元醇粘合剂和压片润滑剂; 干燥失重为0.25％（m / m）以下; 在5-20℃之间放置在3至8个液体盎司的水中时，其完全崩解时间不超过180秒; 并且所述二膦酸盐作为微粉化颗粒掺入或通过喷雾干燥并在2分钟内完全溶解在水中而不搅拌。

公开(公告)号：US5811107A

公开(公告)日：1998-09-22

申请号：US437478

申请日：1995-05-09

Applicant: Balgopal Gangadharan ,  Marshall A. Hayward

Inventor： Balgopal Gangadharan ,  Marshall A. Hayward

IPC: A61K31/78 ,  A61K31/79

CPC classification number: A61K8/8176 ,  A61K8/0212 ,  A61K8/731 ,  A61K8/8164 ,  A61K8/8182 ,  A61K8/86 ,  A61Q19/00 ,  A61Q19/10 ,  A61K2800/28 ,  Y10S514/844 ,  Y10S514/845 ,  Y10S514/846 ,  Y10S514/847 ,  Y10S514/848

Abstract: This invention relates to a polymer-based cleanser for superficial and deep cleansing of skin.

Abstract translation: 本发明涉及一种用于表皮和深层清洁皮肤的基于聚合物的清洁剂。

公开(公告)号：US4916241A

公开(公告)日：1990-04-10

申请号：US205147

申请日：1988-06-06

Applicant: Marshall A. Hayward ,  Joseph P. Sabatucci ,  Ivo L. Jirkovsky ,  Yvon Lefebvre

Inventor： Marshall A. Hayward ,  Joseph P. Sabatucci ,  Ivo L. Jirkovsky ,  Yvon Lefebvre

IPC: C07D307/60 ,  C07D407/06

CPC classification number: C07D407/06 ,  C07D307/60

Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.

Abstract translation: 本发明涉及4-取代-5-羟基-2（5H） - 呋喃酮，其制备方法涉及含有所述4-取代-5-羟基-2（5H） - 呋喃酮的药物组合物，以及使用 所述4-取代-5-羟基-2（5H） - 呋喃酮用于改变包括人在内的宿主动物的骨产生和骨吸收之间的平衡。

公开(公告)号：US5643582A

公开(公告)日：1997-07-01

申请号：US307679

申请日：1994-09-22

Applicant: Balgopal Gangadharan ,  Marshall A. Hayward ,  Denise Lynne Ward

Inventor： Balgopal Gangadharan ,  Marshall A. Hayward ,  Denise Lynne Ward

IPC: A61K9/107 ,  A61K8/00 ,  A61K8/06 ,  A61K8/11 ,  A61K8/31 ,  A61K8/34 ,  A61K8/37 ,  A61K8/72 ,  A61K8/73 ,  A61K8/81 ,  A61K8/92 ,  A61K8/97 ,  A61K9/00 ,  A61K47/38 ,  A61Q11/00 ,  A61Q19/00 ,  A61K7/48

CPC classification number: A61Q19/00 ,  A61K8/11 ,  A61K9/0034 ,  A61K9/006 ,  A61K2800/412 ,  Y10S514/938

Abstract: This invention is a long acting moisturizer particularly suited for moisturizing the epithelia.

Abstract translation: PCT No.PCT / US93 / 02975第 371日期1994年9月22日 102（e）1994年9月22日PCT 1993年3月25日PCT公布。 公开号WO93 / 19733 日期：1993年10月14日本发明是特别适用于保湿上皮的长效保湿剂。

公开(公告)号：US4677132A

公开(公告)日：1987-06-30

申请号：US839013

申请日：1986-03-12

Applicant: Marshall A. Hayward

Inventor： Marshall A. Hayward

IPC: A61K31/405

CPC classification number: A61K31/405

Abstract: A method for modifying the balance between bone production and bone resorption in a host animal by administration of etodolac to inhibit bone resorption.

Abstract translation: 通过施用依托度酸来改变宿主动物的骨产生和骨吸收之间的平衡以抑制骨吸收的方法。

公开(公告)号：US5026725A

公开(公告)日：1991-06-25

申请号：US463091

申请日：1990-02-23

Applicant: Marshall A. Hayward ,  Joseph P. Sabatucci ,  Ivo L. Jirkovsky ,  Yvon Lefebvre

Inventor： Marshall A. Hayward ,  Joseph P. Sabatucci ,  Ivo L. Jirkovsky ,  Yvon Lefebvre

IPC: C07D307/60 ,  C07D407/06

CPC classification number: C07D407/06 ,  C07D307/60

Abstract: This invention relates to 4-substituted-5-hydroxy-2(5H)-furanones, to the process for their preparation, to pharmaceutical compositions containing said 4-substituted-5-hydroxy-2(5H)-furanones and to the use of said 4-substituted-5-hydroxy-2(5H)-furanones for modifying the balance between bone production and bone resorption in a host animal, including man.

Abstract translation: 本发明涉及4-取代-5-羟基-2（5H） - 呋喃酮，其制备方法涉及含有所述4-取代-5-羟基-2（5H） - 呋喃酮的药物组合物，以及使用 所述4-取代-5-羟基-2（5H） - 呋喃酮用于改变包括人在内的宿主动物的骨产生和骨吸收之间的平衡。