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公开(公告)号：US5779676A
公开(公告)日：1998-07-14
申请号：US606090
申请日：1996-02-23
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/152 , A61M31/002 , A61M5/158 , A61M2005/14513 , A61M2005/1581 , A61M2205/197 , A61M2209/045 , A61M5/14248
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane, which in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a novel, conformable ullage made of yieldable materials which uniquely conform to the shape of the elastomeric membrane as the membrane returns to its less distended configuration. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely a rigid ullage construction. Additionally, in one form of the invention, the apparatus includes a novel fill assembly for controllably filling the reservoirs of the device in the field.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该装置具有薄型，层压或分层结构，其具有可膨胀膜形式的储存能量源，其与设备的底部协作限定一个或多个流体储存器，每个流体储存器具有流体入口和流体 出口。 该装置还包括一种由可屈服材料制成的新颖的，顺应性的缺损，当薄膜返回到其较不膨胀的构型时，其可以唯一地符合弹性体膜的形状。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服仅体现在刚性结构构造的装置中遇到的材料选择的限制。 此外，在本发明的一种形式中，该装置包括一个新颖的填充组件，用于在现场可控地填充装置的储存器。
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公开(公告)号：US5716343A
公开(公告)日：1998-02-10
申请号：US540914
申请日：1995-10-11
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/14248 , A61M5/1409 , A61M5/1413 , A61M5/152 , A61M2005/1581 , A61M2205/197 , A61M5/1407 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate construction having a stored energy source in the form of a distendable membrane, which in cooperation with the base of the apparatus defines one or more fluid reservoirs each having a fluid inlet and a fluid outlet. The apparatus further includes a novel, conformable ullage made of formable materials. The conformable ullage uniquely conforms to the shape of elastomeric membrane as the membrane returns to its less distend configuration and in so doing can move between a central chamber and a toroidal chamber formed in the cover of the apparatus. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely rigid ullage construction. Additionally, the infusion cannula of the apparatus is connected to the base in a novel manner which permits expeditious subdermal delivery to the patient via a cannula which extends generally perpendicularly relative to the base.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该设备是具有低膨胀层压结构，其具有可膨胀膜形式的储存能量源，其与设备的底部配合限定一个或多个流体储存器，每个流体储存器具有流体入口和流体出口。 该装置还包括由可成形材料制成的新颖的，一致的缺口。 当膜返回到较小的膨胀构型时，适形的空隙与弹性体膜的形状完全一致，并且这样做可以在中心室和形成在装置的盖中的环形室之间移动。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服在体现仅仅刚性结构的装置中遇到的材料选择的限制。 此外，装置的输液插管以新颖的方式连接到基部，其允许通过相对于基部大致垂直延伸的套管快速皮下递送给患者。
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公开(公告)号：US5921962A
公开(公告)日：1999-07-13
申请号：US991122
申请日：1997-12-16
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/158 , A61M31/002 , A61M5/152 , A61M2005/14513 , A61M2005/1581 , A61M2205/197 , A61M2209/045 , A61M5/14248 , Y10S128/12
摘要： A fluid delivery device for infusing medicinal fluids having a self-contained stored energy membrane for expelling fluids at a precisely controlled rate. The device is of a compact, low profile, laminate construction so that it can conveniently be used for the fluids, such as insulin and the like, into an ambulatory patient at controlled rates over extended periods of time. Included within the device are various fluid flow control elements including a unique hydraulic fluid rate control system for ultra low flow delivery. Also included is a highly novel flow indictor for providing a positive indication of fluid flow from the device and for indicating at any given time the amount of fluid remaining in the device.
摘要翻译： 一种流体输送装置，用于输注具有独立储存能量膜的药液，以精确控制的速率排出流体。 该装置具有紧凑，薄型的层压结构，使得其可以方便地用于诸如胰岛素等的流体，并且在长时间段内以受控的速率进入流动患者。 包括在装置内的是各种流体流量控制元件，包括用于超低流量输送的独特的液压流体速率控制系统。 还包括一种高度新颖的流量指示器，用于提供来自装置的流体流动的积极指示，并且用于在任何给定时间指示剩余在装置中的流体量。
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公开(公告)号：US5735818A
公开(公告)日：1998-04-07
申请号：US541183
申请日：1995-10-11
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M5/14244
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane, which, in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a novel conformable ullage made of yieldable materials. The conformable ullage uniquely conforms to the geometry of elastomeric membrane as the membrane returns to its less distended configuration and in so doing can move between a central chamber and a toroidal chamber formed in the cover of the apparatus. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely a rigid ullage construction. Additionally, the infusion cannula of the apparatus is connected to the base in a novel manner which permits expeditious subdermal delivery to the patient via a cannula which extends generally perpendicularly relative to the base.
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公开(公告)号：US5906592A
公开(公告)日：1999-05-25
申请号：US907564
申请日：1997-08-08
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C Barber , William J. Kluck
CPC分类号： A61M5/1409 , A61M5/1413 , A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M2205/197 , A61M5/1407 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time and the method for making same. The apparatus includes one or more dispensers of a low profile, laminate or layered construction each having a stored energy source in the form of a distendable membrane or an elastomeric cellular mass, which in cooperation with the base, defined a fluid chamber having a fluid inlet and a fluid outlet. The apparatus further includes, in lieu of a rigid ullage, a high novel, conformable ullage made of yieldable materials. The conformable ullage uniquely conforms to the shape of elastomeric membrane as the membrane returns to its less distended configuration. This arrangement will satisfy even the most stringent delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying the rigid ullage construction. Additionally, with the novel ullage construction, the ullage can be located either between the base and the fluid to be delivered, or alternatively, can be located between the elastomeric membrane and the fluid to be delivered. Further, a plurality of subreservoirs can be associated with a single ullage thereby making it possible to incorporate a wide variety of delivery profiles within a single device.
摘要翻译： 一种用于在更长时间内以特定速率准确地将流体注入患者体内的装置及其制造方法。 该设备包括一个或多个低分布，层压或分层结构的分配器，每个分配器具有可膨胀膜或弹性体泡沫体形式的储存能源，其与基底配合，限定了具有流体入口 和流体出口。 该装置还包括代替刚性缺损的由可屈服材料制成的高度新颖的，适合的缺口。 随着膜返回到较少膨胀的构型，适形的填充与弹性膜的形状完全一致。 这种布置将满足最严格的交货公差要求，并且将优雅地克服在体现刚性空间结构的装置中遇到的材料选择的限制。 另外，随着新颖的空白结构，空白可以位于基底和要输送的流体之间，或者可以位于弹性膜和要输送的流体之间。 此外，多个子储存器可以与单个空白相关联，从而使得可以在单个装置内并入多种递送曲线。
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公开(公告)号：US5776103A
公开(公告)日：1998-07-07
申请号：US541184
申请日：1995-10-11
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/158 , A61M31/002 , A61M5/152 , A61M2005/14513 , A61M2005/1581 , A61M2205/197 , A61M2209/045 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane, which, in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a novel, conformable ullage made of yieldable materials which uniquely conforms to the shape of the elastomeric membrane as the membrane returns to its less distended configuration. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely a rigid ullage construction. Additionally, in one form of the invention, the infusion cannula of the apparatus is connected to the base of the apparatus in a novel manner which permits expeditious subdermal delivery of liquid medicaments to the patient via a cannula which extends generally perpendicularly from the base.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该装置具有薄型，层压或分层结构，其具有可膨胀膜形式的储存能量源，其与装置的底部协作限定一个或多个流体储存器，每个具有流体入口和 流体出口。 该装置还包括一种由可屈服材料制成的新颖的，顺应性的填充物，当薄膜返回到其较不膨胀的构型时，其完全符合弹性体膜的形状。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服仅体现在刚性结构构造的装置中遇到的材料选择的限制。 另外，在本发明的一种形式中，该设备的输液插管以新颖的方式连接到设备的底座上，该新颖方式允许液体药物通过大体上垂直于基部垂直延伸的套管迅速向皮肤递送液体药物。
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公开(公告)号：US5885250A
公开(公告)日：1999-03-23
申请号：US991930
申请日：1997-12-16
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W.. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W.. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M5/14244
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane, which, in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a novel conformable ullage made of yieldable materials. The conformable ullage uniquely conforms to the geometry of elastomeric membrane as the membrane returns to its less distended configuration and in so doing can move between a central chamber and a toroidal chamber formed in the cover of the apparatus. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely a rigid ullage construction. Additionally, the infusion cannula of the apparatus is connected to the base in a novel manner which permits expeditious subdermal delivery to the patient via a cannula which extends generally perpendicularly relative to the base.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该装置具有薄型，层压或分层结构，其具有可膨胀膜形式的储存能量源，其与装置的底部协作限定一个或多个流体储存器，每个具有流体入口和 流体出口。 该设备还包括由可屈服材料制成的新颖的顺应性空白。 当膜返回到较小的膨胀构型时，顺应性的缺损唯一地符合弹性体膜的几何形状，并且这样做可以在形成在装置的盖中的中心室和环形室之间移动。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服仅体现在刚性结构构造的装置中遇到的材料选择的限制。 此外，装置的输液插管以新颖的方式连接到基部，其允许通过相对于基部大致垂直延伸的套管快速皮下递送给患者。
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公开(公告)号：US5693018A
公开(公告)日：1997-12-02
申请号：US541030
申请日：1995-10-11
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/14248 , A61M5/152 , A61M2005/1581 , A61M5/14244 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane, which, in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a high novel, conformable ullage made of yieldable materials. The conformable ullage uniquely conforms to the shape of elastomeric membrane as the membrane returns to its less distended configuration. Additionally, the infusion cannula of the apparatus is connected to the base in a novel manner which permits expeditious subdermal delivery to the patient via a cannula which extends generally perpendicularly relative to the base. The cannula is connected to the base in a manner such that the pierceable portion of the cannula is free to move relative to the base of the device in response to movements by the patient which cause flexing of the muscle and tissue in the vicinity of the cannula.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该装置具有薄型，层压或分层结构，其具有可膨胀膜形式的储存能量源，其与装置的底部协作限定一个或多个流体储存器，每个具有流体入口和 流体出口。 该装置还包括由可屈服材料制成的高度新颖的，一致的包装。 随着膜返回到较少膨胀的构型，适形的填充与弹性膜的形状完全一致。 此外，装置的输液插管以新颖的方式连接到基部，其允许通过相对于基部大致垂直延伸的套管快速皮下递送给患者。 插管以这样的方式连接到基部，使得套管的可刺穿部分响应于患者的运动而相对于装置的基部自由移动，这导致患者的运动导致套管附近的肌肉和组织的弯曲 。
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公开(公告)号：US6068613A
公开(公告)日：2000-05-30
申请号：US991928
申请日：1997-12-16
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/14248 , A61M5/1409 , A61M5/1413 , A61M5/152 , A61M2005/1581 , A61M2205/197 , A61M5/1407 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate construction having a stored energy source in the form of a distendable membrane, which in cooperation with the base of the apparatus defines one or more fluid reservoirs each having a fluid inlet and a fluid outlet. The apparatus further includes a novel, conformable ullage made of formable materials. The conformable ullage uniquely conforms to the shape of elastomeric membrane as the membrane returns to its less distend configuration and in so doing can move between a central chamber and a toroidal chamber formed in the cover of the apparatus. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely rigid ullage construction. Additionally, the infusion cannula of the apparatus is connected to the base in a novel manner which permits expeditious subdermal delivery to the patient via a cannula which extends generally perpendicularly relative to the base.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该设备是具有低膨胀层压结构，其具有可膨胀膜形式的储存能量源，其与设备的底部配合限定一个或多个流体储存器，每个流体储存器具有流体入口和流体出口。 该装置还包括由可成形材料制成的新颖的，一致的缺口。 当膜返回到较小的膨胀构型时，适形的空隙与弹性体膜的形状完全一致，并且这样做可以在中心室和形成在装置的盖中的环形室之间移动。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服在体现仅仅刚性结构的装置中遇到的材料选择的限制。 此外，装置的输液插管以新颖的方式连接到基部，其允许通过相对于基部大致垂直延伸的套管快速皮下递送给患者。
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公开(公告)号：US5925017A
公开(公告)日：1999-07-20
申请号：US991121
申请日：1997-12-16
申请人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
发明人： Marshall S. Kriesel , Farhad Kazemzadeh , Matthew B. Kriesel , William W. Feng , Steve C. Barber , William J. Kluck
CPC分类号： A61M5/158 , A61M31/002 , A61M5/152 , A61M2005/14513 , A61M2005/1581 , A61M2205/197 , A61M2209/045 , A61M5/14248 , Y10S128/12
摘要： An apparatus for accurately infusing fluids into a patient at specific rates over an extended period of time. The apparatus is of a low profile, laminate or layered construction having a stored energy source in the form of a distendable membrane which, in cooperation with the base of the apparatus, defines one or more fluid reservoirs, each having a fluid inlet and a fluid outlet. The apparatus further includes, a novel, conformable ullage made of yieldable materials which uniquely conforms to the shape of the elastomeric membrane as the membrane returns to its less distended configuration. This arrangement will satisfy even the most stringent medicament delivery tolerance requirements and will elegantly overcome the limitations of materials selection encountered in devices embodying solely a rigid ullage construction. Additionally, in one form of the invention, the infusion cannula of the apparatus is connected to the base of the apparatus in a novel manner which permits expeditious subdermal delivery of liquid medicaments to the patient via a cannula which extends generally perpendicularly from the base.
摘要翻译： 一种用于在较长时间内以特定速率准确地将流体输入患者体内的装置。 该装置具有薄型，层压或分层结构，其具有可膨胀膜形式的储存能量源，其与装置的底部协作限定一个或多个流体储存器，每个具有流体入口和流体 出口。 该装置还包括一种由可屈服材料制成的新颖的，顺应性的填充物，当薄膜返回到其较不膨胀的构型时，其完全符合弹性体膜的形状。 这种布置将满足甚至最严格的药物输送公差要求，并且将优雅地克服仅体现在刚性结构构造的装置中遇到的材料选择的限制。 另外，在本发明的一种形式中，该设备的输液插管以新颖的方式连接到设备的底座上，该新颖方式允许液体药物通过大体上垂直于基部垂直延伸的套管迅速向皮肤递送液体药物。
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