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    Correction of deadtime effects in mass spectrometry
    1.
    发明授权
    Correction of deadtime effects in mass spectrometry 有权
    修正质谱中的死时效应

    公开(公告)号：US08106350B2

    公开(公告)日：2012-01-31

    申请号：US11816643

    申请日：2006-02-22

    申请人： Martin Green ,  Jason Lee Wildgoose ,  Marc V. Gorenstein

    发明人： Martin Green ,  Jason Lee Wildgoose ,  Marc V. Gorenstein

    IPC分类号： H01J49/26

    CPC分类号： H01J49/025 ,  H01J49/0036 ,  H01J49/40

    摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.

    摘要翻译： 公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数 记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。

    MASS SPECTROMETER
    2.
    发明申请
    MASS SPECTROMETER 有权
    质谱仪

    公开(公告)号：US20090057547A1

    公开(公告)日：2009-03-05

    申请号：US11816643

    申请日：2006-02-22

    申请人： Martin Green ,  Jason Lee Wildgoose ,  Marc V. Gorenstein

    发明人： Martin Green ,  Jason Lee Wildgoose ,  Marc V. Gorenstein

    IPC分类号： B01D59/44 ,  H01J49/40

    CPC分类号： H01J49/025 ,  H01J49/0036 ,  H01J49/40

    摘要： A method of mass spectrometry is disclosed wherein distortions in a mass spectrum are corrected for by determining or estimating the number of ions Qi which arrived in an ith time bin, wherein: Formula (I) and wherein qi is the actual total number of ion arrival events recorded in the ith time bin and x is an integer corresponding to the number of time bins which correspond with an estimated deadtime period.

    摘要翻译： 公开了一种质谱法，其中通过确定或估计到达第i个时间仓的离子数Qi来校正质谱中的失真，其中：式（I），其中qi是离子到达的实际总数 记录在第i个时间段中的事件和x是对应于与估计的死时间周期相对应的时间段数的整数。

    Method of using data binning in the analysis of chromatography/spectrometry data
    6.
    发明授权
    Method of using data binning in the analysis of chromatography/spectrometry data 有权
    在色谱/光谱数据分析中使用数据合并的方法

    公开(公告)号：US07418352B2

    公开(公告)日：2008-08-26

    申请号：US11480254

    申请日：2006-06-30

    申请人： Robert Stephen Plumb ,  Chris Lee Stumpf ,  Marc V. Gorenstein

    发明人： Robert Stephen Plumb ,  Chris Lee Stumpf ,  Marc V. Gorenstein

    IPC分类号： G06F19/00 ,  G06F11/30 ,  H01J49/00

    CPC分类号： H01J49/0036 ,  G01N30/8675 ,  G06F19/24

    摘要： Disclosed herein is a method of analyzing three-dimensional data obtained from a chromatography/spectrometry process, in particular an LC/MS process using a two-dimensional multi-variant statistical analysis. The LC portion permits separation of analytes within a sample. The information obtained from such a procedure typically depends on retention time (Rt). As the analytes progress through the system, they enter the MS region of the LC/MS system. There they are ionized and a mass detector then detects these ionized species. The information procured from this procedure is generally reported as intensity for a corresponding m/z value. Therefore, an LC/MS system provides at least three pieces of information. Principle component analysis (PCA) is a robust method of multi-variant analysis of this type of data between different samples. However, typically, PCA analysis is performed using only two-dimensional data. Therefore, it is expected that at least one parameter of data obtained from a LC/MS operation is lost, however, the methods disclosed herein preserves all three mathematical dimensions.

    摘要翻译： 本文公开了一种分析从色谱/光谱测定方法获得的三维数据的方法，特别是使用二维多变量统计分析的LC / MS方法。 LC部分允许分离样品内的分析物。 从这种方法获得的信息通常取决于保留时间（R t t T t）。 当分析物通过系统进入时，它们进入LC / MS系统的MS区域。 在那里它们被离子化，质量检测器然后检测这些电离物质。 从该程序获得的信息通常被报告为对应的m / z值的强度。 因此，LC / MS系统提供至少三条信息。 原理分量分析（PCA）是对不同样本之间的这种类型的数据进行多变量分析的有力方法。 然而，通常，仅使用二维数据来执行PCA分析。 因此，期望从LC / MS操作获得的数据的至少一个参数丢失，然而，本文公开的方法保留所有三个数学维度。

    Method and devices for chromatographic pattern analysis employing chromatographic variability characterization
    7.
    发明授权
    Method and devices for chromatographic pattern analysis employing chromatographic variability characterization 失效
    使用色谱变异性表征的色谱图案分析的方法和装置

    公开(公告)号：US5969228A

    公开(公告)日：1999-10-19

    申请号：US936168

    申请日：1997-09-23

    申请人： Marc V. Gorenstein

    发明人： Marc V. Gorenstein

    IPC分类号： G01N30/86 ,  G01N30/88 ,  B01D15/08

    CPC分类号： G01N30/8665 ,  G01N30/8624 ,  G01N30/88 ,  G01N2030/8804 ,  G01N2030/8809 ,  G01N30/8641

    摘要： Method and devices for performing chromatographic pattern analysis determine chromatographic variability due to a plurality of sources without requiring identification or characterization of peaks or other chromatographic features, receives data indicative of a standard chromatogram and a first sample chromatogram generated from a first mixture by a High Pressure Liquid Chromatography (HPLC) device and data indicative of a plurality of additional sample chromatograms generated by the HPLC device from a plurality of different mixtures. The method and devices generate from the standard chromatogram, a plurality of sets of chromatographic variability data, each set being indicative of a different effect of the chromatographic variability of the HPLC. The standard chromatogram is modified as a function of the variability data, and a residual value, indicative of a difference between the modified standard chromatograms and the first sample chromatogram is generated. Residual values are generated for the additional sample chromatograms and are used to determine differences between the corresponding mixtures and the first mixture.

    摘要翻译： 用于进行色谱图分析的方法和装置由于多个来源而确定色谱变异性，而不需要鉴定或表征峰或其他色谱特征，接收指示标准色谱图的数据和通过高压产生的第一混合物的第一样品色谱图 液相色谱（HPLC）装置和指示由HPLC装置从多种不同混合物产生的多个附加样品色谱图的数据。 该方法和装置从标准色谱图产生多组色谱变异性数据，每组都表示HPLC的色谱变异性的不同影响。 标准色谱被修改为变异性数据的函数，并且生成表示修改的标准色谱图与第一样品色谱图之间的差异的残留值。 为附加样品色谱图生成残留值，并用于确定相应混合物和第一混合物之间的差异。

    Method and apparatus for determining the boundaries of a detector response profile and for controlling processes
    10.
    发明授权
    Method and apparatus for determining the boundaries of a detector response profile and for controlling processes 有权
    用于确定检测器响应曲线的边界并用于控制过程的方法和装置

    公开(公告)号：US06694265B2

    公开(公告)日：2004-02-17

    申请号：US09949199

    申请日：2001-09-07

    申请人： Marc V. Gorenstein

    发明人： Marc V. Gorenstein

    IPC分类号： G06F1900

    CPC分类号： G01N30/8624 ,  G01N30/82 ,  G01N30/8603 ,  G01N30/861 ,  G01N30/8627 ,  G01N30/8631 ,  G01N30/8634 ,  G01N30/8641

    摘要： An improved method and apparatus for identifying peaks and for determining the boundaries of those peaks, and boundaries of multiple peaks and shoulders within chromatograms. The method and apparatus effects real time identification and determination of the boundaries of these peaks for the purpose of fraction collection. The method and apparatus determines the boundary of a peak within a detector response profile that comprises data points plotted graphically on an X and Y-axis wherein the X-axis represents a first variable and the Y-axis represents a second variable, each variable having a value. The plot at each of the data points has a slope. Data points having a slope which deviates from a consistent value define a peak, and data points having a slope with a consistent value define a baseline.

    摘要翻译： 一种改进的方法和装置，用于鉴定峰和确定这些峰的边界，以及色谱图内多个峰和肩的边界。 该方法和装置实现了这些峰的边界的实时鉴定和确定，用于分馏收集。 所述方法和装置确定检测器响应曲线内的峰值的边界，其包括在X和Y轴上以图形方式绘制的数据点，其中X轴表示第一变量，Y轴表示第二变量，每个变量具有 一个值。 每个数据点的曲线都有一个斜率。 具有偏离一致值的斜率的数据点定义峰值，具有一致值的斜率的数据点定义基线。