-
公开(公告)号：US20110312025A1
公开(公告)日：2011-12-22
申请号：US13127618
申请日：2009-11-09
摘要： The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.
摘要翻译： 本发明通过在含有核黄素生物合成基因（rib操纵子）的操纵子中进行修饰，特别是在对应的上游的前导序列（rib前导序列）中的修饰来提供核黄素（本文中也称为维生素B2）的改进的生物技术生产 核黄素生物合成基因（rib操纵子）。 此外，本发明涉及携带所述修饰序列的遗传工程微生物，产生所述修饰序列/微生物的方法及其用于生产核黄素的用途。
-
公开(公告)号：US20080311617A1
公开(公告)日：2008-12-18
申请号：US12091279
申请日：2006-10-25
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及产生突变的转酮酶，其允许在葡萄糖上正常生长，但当被引入生产菌株中时葡萄糖酸盐的生长减少，以及编码它们的多核苷酸。
-
公开(公告)号：US20130189731A1
公开(公告)日：2013-07-25
申请号：US13558517
申请日：2012-07-26
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及允许在葡萄糖上正常生长但在引入生产菌株中时降低葡萄糖酸盐生长并且编码它们的多核苷酸的突变转酮酶的产生。
-
公开(公告)号：US09315784B2
公开(公告)日：2016-04-19
申请号：US13558517
申请日：2012-07-26
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及产生突变的转酮酶，其允许在葡萄糖上正常生长，但当被引入生产菌株中时葡萄糖酸盐的生长减少，以及编码它们的多核苷酸。
-
公开(公告)号：US08257944B2
公开(公告)日：2012-09-04
申请号：US12091279
申请日：2006-10-25
IPC分类号： C12P25/00 , C12N1/20 , C12N9/10 , C07D491/00
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，它还涉及允许葡萄糖正常生长但在引入生产菌株中时减少葡萄糖酸盐生长并且编码它们的多核苷酸的突变转酮酶的产生。
-
-
-
-
搜索结果
5 条记录 (耗时 0.021 秒)