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公开(公告)号：US20080311617A1
公开(公告)日：2008-12-18
申请号：US12091279
申请日：2006-10-25
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及产生突变的转酮酶，其允许在葡萄糖上正常生长，但当被引入生产菌株中时葡萄糖酸盐的生长减少，以及编码它们的多核苷酸。
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公开(公告)号：US20110312025A1
公开(公告)日：2011-12-22
申请号：US13127618
申请日：2009-11-09
摘要： The present invention provides an improved biotechnological production of riboflavin (also referred herein as vitamin B2) through modification in the operon containing the riboflavin biosynthetic genes (rib operon), in particular modifications of/in the leader sequences (rib leader) upstream of the corresponding riboflavin biosynthetic genes (rib operon). Furthermore, the present invention relates to genetically engineered microorganisms carrying said modified sequences, processes to generate said modified sequences/microorganisms and the use thereof for production of riboflavin.
摘要翻译： 本发明通过在含有核黄素生物合成基因（rib操纵子）的操纵子中进行修饰，特别是在对应的上游的前导序列（rib前导序列）中的修饰来提供核黄素（本文中也称为维生素B2）的改进的生物技术生产 核黄素生物合成基因（rib操纵子）。 此外，本发明涉及携带所述修饰序列的遗传工程微生物，产生所述修饰序列/微生物的方法及其用于生产核黄素的用途。
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公开(公告)号：US20130189731A1
公开(公告)日：2013-07-25
申请号：US13558517
申请日：2012-07-26
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及允许在葡萄糖上正常生长但在引入生产菌株中时降低葡萄糖酸盐生长并且编码它们的多核苷酸的突变转酮酶的产生。
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公开(公告)号：US09315784B2
公开(公告)日：2016-04-19
申请号：US13558517
申请日：2012-07-26
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，还涉及产生突变的转酮酶，其允许在葡萄糖上正常生长，但当被引入生产菌株中时葡萄糖酸盐的生长减少，以及编码它们的多核苷酸。
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公开(公告)号：US08257944B2
公开(公告)日：2012-09-04
申请号：US12091279
申请日：2006-10-25
IPC分类号： C12P25/00 , C12N1/20 , C12N9/10 , C07D491/00
CPC分类号： C12N9/1022 , C12P17/12 , C12P25/00
摘要： The present invention relates to a improved process for the biotechnological production of compounds for which ribose-5-phosphate, ribulose-5-phosphate or xylulose-5-phosphate is biosynthetic precursor like riboflavin (vitamin B2), FAD, FMN, pyridoxal phosphate (vitamin B6), guanosine, GMP, adenosine, AMP. The invention further pertains to the generation of the organism producing those compounds. It furthermore relates to the generation of mutated transketolases that allow normal growth on glucose but reduced growth on gluconate when introduced into the production strains and to polynucleotides encoding them.
摘要翻译： 本发明涉及核糖-5-磷酸，核酮糖-5-磷酸或木酮糖-5-磷酸是生物合成前体如核黄素（维生素B2），FAD，FMN，吡哆醛磷酸酯（ 维生素B6），鸟苷，GMP，腺苷，AMP。 本发明还涉及产生这些化合物的生物体的产生。 此外，它还涉及允许葡萄糖正常生长但在引入生产菌株中时减少葡萄糖酸盐生长并且编码它们的多核苷酸的突变转酮酶的产生。
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6.发明授权Method for removing the hard material coating applied on a hard metal workpiece and a holding device for at least one workpiece 有权用于去除施加在硬金属工件上的硬质材料涂层和用于至少一个工件的保持装置的方法公开(公告)号：US06627064B1
公开(公告)日：2003-09-30
申请号：US09693906
申请日：2000-10-23
申请人： Michael Hans
发明人： Michael Hans
IPC分类号： C25F500
摘要： A hard material layer deposited on a hard metal work piece is removed by electrolytic passivation in which a maximum current density equal to at least 0.01 A/cm2 is generated on the work piece at the beginning of the layer removal process. The hard material layer rapidly flakes off without causing substantial damage to the hard metal material located underneath.
摘要翻译： 通过电解钝化去除沉积在硬金属工件上的硬质材料层，其中在层去除过程开始时，在工件上产生等于至少0.01A / cm 2的最大电流密度。 硬质材料层快速剥落而不会对位于下方的硬质金属材料造成实质性损坏。
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7.发明申请METHOD OF MOUNTING AND REGISTERING A PRINTING PLATE ON A PLATE CYLINDER OF A MULTI-COLOR OFFSET PRINTING PRESS 有权在多色偏移印刷机的板式气缸上安装和注册印刷板的方法公开(公告)号：US20140238257A1
公开(公告)日：2014-08-28
申请号：US14127143
申请日：2012-07-02
IPC分类号： B41F27/00
CPC分类号： B41F27/005 , B41F7/025 , B41F27/1231 , B41P2227/42
摘要： A method of mounting and adjusting a printing plate on a plate cylinder of a multicolor offset printing press is described. The printing plate is clamped between front and rear clamping bars, the rear clamping bar being movable under the application of a tensioning force and occupying, upon clamping of the trailing end of the printing plate, a tension-release position. Tensioning of the printing plate is carried out by initially applying a nominal tensioning force to the rear clamping bar. A print register of the tensioned printing plate is then measured and compared to a target print register to determine a corrected tensioning position of the rear clamping bar corresponding to the target print register. The tension of the printing plate is thereafter released. The correct tensioning position is set as new reference position of the rear clamping bar before or after tensioning again the printing plate.
摘要翻译： 描述了一种在多色胶版印刷机的印版滚筒上安装和调整印版的方法。 印版被夹在前夹紧杆和后夹紧杆之间，后夹紧杆可在施加张紧力的作用下移动，并且在夹持印版的尾端时占据张力释放位置。 通过首先对后夹紧杆施加标称张力来进行印版的张紧。 然后测量张紧印版的打印寄存器，并将其与目标打印寄存器进行比较，以确定与目标打印寄存器对应的后夹紧条的校正张紧位置。 此后印版的张力被释放。 正确的张紧位置在再次张紧印版之前或之后设定为后夹紧杆的新基准位置。
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公开(公告)号：US06471837B1
公开(公告)日：2002-10-29
申请号：US09537293
申请日：2000-03-29
申请人： Michael Hans , Martin Zaech
发明人： Michael Hans , Martin Zaech
IPC分类号： C23C1434
CPC分类号： C23C14/505 , B01J3/03 , C23C14/566 , C23C14/568
摘要： A vacuum coating installation has at least a central distribution station which can be evacuated and has a transport arrangement driven in a controlled manner essentially along a plane, for the material to be treated. One operating station for the distribution station as well as at least two processing stations for the material to be treated are provided. The three or more stations communicate by way of operating openings with the distribution station, through which openings the material to be treated can be transported from one station into the other by the transport arrangement for the material to be treated. The material to be treated is formed by individual workpiece holders of the installation, each having a plurality of workpiece supports. On at least one of the processing stations, a drive and a driving connection, which can be established and released in a controlled manner, between the drive and the workpiece supports of a workpiece holder introduced in the processing station is provided for ensuring a three-dimensional workpiece processing in the processing station.
摘要翻译： 真空镀膜装置至少具有一个中央分配站，该中心分配站可被排空，并且具有以受控方式驱动的输送装置，基本上沿平面驱动待处理材料。 提供了用于配送站的一个操作站以及用于待处理材料的至少两个处理站。 三个或更多个站通过与分配站的操作开口进行通信，通过该开口，待处理材料可以通过待处理材料的输送装置从一个站传送到另一个站。 待处理的材料由安装的各个工件保持器形成，每个具有多个工件支撑件。 在至少一个处理站中，提供可以以受控的方式建立和释放的驱动和驱动连接在驱动器和引入到处理站中的工件保持件的工件支撑件之间， 在加工站的三维工件加工。
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9.发明授权Method of mounting and registering a printing plate on a plate cylinder of a multi-color offset printing press 有权在多色胶版印刷机的印版滚筒上安装和对准印版的方法公开(公告)号：US08943967B2
公开(公告)日：2015-02-03
申请号：US14127143
申请日：2012-07-02
CPC分类号： B41F27/005 , B41F7/025 , B41F27/1231 , B41P2227/42
摘要： A method of mounting and adjusting a printing plate on a plate cylinder of a multicolor offset printing press is described. The printing plate is clamped between front and rear clamping bars, the rear clamping bar being movable under the application of a tensioning force and occupying, upon clamping of the trailing end of the printing plate, a tension-release position. Tensioning of the printing plate is carried out by initially applying a nominal tensioning force to the rear clamping bar. A print register of the tensioned printing plate is then measured and compared to a target print register to determine a corrected tensioning position of the rear clamping bar corresponding to the target print register. The tension of the printing plate is thereafter released. The correct tensioning position is set as new reference position of the rear clamping bar before or after tensioning again the printing plate.
摘要翻译： 描述了一种在多色胶版印刷机的印版滚筒上安装和调整印版的方法。 印版被夹在前夹紧杆和后夹紧杆之间，后夹紧杆可在施加张紧力的作用下移动，并且在夹持印版的尾端时占据张力释放位置。 通过首先对后夹紧杆施加标称张力来进行印版的张紧。 然后测量张紧印版的打印寄存器，并将其与目标打印寄存器进行比较，以确定与目标打印寄存器对应的后夹紧条的校正张紧位置。 此后印版的张力被释放。 正确的张紧位置在再次张紧印版之前或之后设定为后夹紧杆的新基准位置。
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