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    DETECTION OF MUTATIONS, IN PARTICULAR DELETIONS OR INSERTIONS
    3.
    发明申请
    DETECTION OF MUTATIONS, IN PARTICULAR DELETIONS OR INSERTIONS 审中-公开
    检测突变，特别是删除或插入

    公开(公告)号：US20130302798A1

    公开(公告)日：2013-11-14

    申请号：US13808600

    申请日：2011-07-04

    申请人： Martin Schuler ,  Frank Breitenbuecher ,  Sandra Hoffarth ,  Sarah-Luise Boeck

    发明人： Martin Schuler ,  Frank Breitenbuecher ,  Sandra Hoffarth ,  Sarah-Luise Boeck

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q1/6827 ,  C12Q1/6858 ,  C12Q2600/156 ,  C12Q2537/163 ,  C12Q2531/107 ,  C12Q2527/107 ,  C12Q2565/101

    摘要： A method for detecting at least one gene modification, such as a mutation in a gene, such as a gene that codes for a protein associated with at least one of a tumor and a cancer. The method includes providing a detectable hybridization probe (sensor probe) which interacts with/binds to a gene not having a gene modification (wild type gene) and with a gene having a gene modification (mutation gene). The detectable hybridization probe (sensor probe) has at least one of a higher specificity, a higher binding affinity and a higher selectivity for the gene not having a gene modification (wild type gene) compared to the gene having a gene modification (mutation gene). At least one gene modification is detected with the detectable hybridization probe (sensor probe).

    摘要翻译： 用于检测至少一种基因修饰的方法，例如基因中的突变，例如编码与至少一种肿瘤和癌症相关的蛋白质的基因。 该方法包括提供与不具有基因修饰基因（野生型基因）和具有基因修饰基因（突变基因）相互作用/结合的可检测杂交探针（传感器探针）。 与具有基因修饰的基因（突变基因）相比，可检测杂交探针（传感器探针）具有更高的特异性，更高的结合亲和力和对不具有基因修饰的基因（野生型基因）的较高选择性， 。 用可检测的杂交探针（传感器探针）检测至少一个基因修饰。

    Rock drilling in great depths by thermal fragmentation using highly exothermic reactions evolving in the environment of a water-based drilling fluid
    5.
    发明授权
    Rock drilling in great depths by thermal fragmentation using highly exothermic reactions evolving in the environment of a water-based drilling fluid 有权
    通过在水基钻井液的环境中演化的高放热反应，通过热分解进行深度钻探

    公开(公告)号：US08967293B2

    公开(公告)日：2015-03-03

    申请号：US13141349

    申请日：2009-12-22

    申请人： Philipp Rudolf Von Rohr ,  Tobias Rothenfluh ,  Martin Schuler

    发明人： Philipp Rudolf Von Rohr ,  Tobias Rothenfluh ,  Martin Schuler

    IPC分类号： E21B7/14

    CPC分类号： E21B7/14

    摘要： A method and a device to thermally fragment rock for excavation of vertical and directional boreholes in rock formations, preferentially hard rock, using highly exothermic reactions. Exothermic reactions are initiated directly in the pressurized, aqueous environment of a water-based drilling fluid preferably above the critical pressure of water (221 bar). After reaction onset temperatures within the reaction zone exceed the critical temperature for water (374° C.) providing supercritical conditions, which favor the stabilization of the reaction, e.g. a supercritical hydrothermal flame. Since reactions can be run directly in a water-based drilling fluid, the method proposed here allows high density drilling action as in conventional rotary drilling. A part from the hot reaction zone of the proposed reaction can be brought directly to the rock surface in case of hard polycrystalline rock, where high temperatures are required.

    摘要翻译： 使用高度放热反应，岩石中的垂直和定向钻孔的岩石热分解方法和装置，优选硬岩。 放热反应直接在水基钻井液的加压水溶液环境中引发，优选高于水的临界压力（221巴）。 在反应区域内的反应起始温度超过提供超临界条件的水（374℃）的临界温度，这有利于反应的稳定，例如， 超临界水热火焰。 由于反应可以直接在水基钻井液中运行，所以这里提出的方法允许高密度钻井作用，如在常规旋转钻井中。 在需要高温的硬质多晶岩的情况下，所提出的反应的热反应区的一部分可以直接带到岩石表面。

    ROCK DRILLING IN GREAT DEPTHS BY THERMAL FRAGMENTATION USING HIGHLY EXOTHERMIC REACTIONS EVOLVING IN THE ENVIRONMENT OF A WATER-BASED DRILLING FLUID
    6.
    发明申请
    ROCK DRILLING IN GREAT DEPTHS BY THERMAL FRAGMENTATION USING HIGHLY EXOTHERMIC REACTIONS EVOLVING IN THE ENVIRONMENT OF A WATER-BASED DRILLING FLUID 有权
    通过在水基钻井液的环境中发展的高度热灭反应的热裂解，在大量深度钻探

    公开(公告)号：US20110303460A1

    公开(公告)日：2011-12-15

    申请号：US13141349

    申请日：2009-12-22

    申请人： Philipp Rudolf Von Rohr ,  Tobias Rothenfluh ,  Martin Schuler

    发明人： Philipp Rudolf Von Rohr ,  Tobias Rothenfluh ,  Martin Schuler

    IPC分类号： E21B7/14

    CPC分类号： E21B7/14

    摘要： A method and a device to thermally fragment rock for excavation of vertical and directional boreholes in rock formations, preferentially hard rock, using highly exothermic reactions. Exothermic reactions are initiated directly in the pressurized, aqueous environment of a water-based drilling fluid preferably above the critical pressure of water (221 bar). After reaction onset temperatures within the reaction zone exceed the critical temperature for water (374° C.) providing supercritical conditions, which favor the stabilization of the reaction, e.g. a supercritical hydrothermal flame. Since reactions can be run directly in a water-based drilling fluid, the method proposed here allows high density drilling action as in conventional rotary drilling. A part from the hot reaction zone of the proposed reaction can be brought directly to the rock surface in case of hard polycrystalline rock, where high temperatures are required.

    摘要翻译： 使用高度放热反应，岩石中的垂直和定向钻孔的岩石热分解方法和装置，优选硬岩。 放热反应直接在水基钻井液的加压水溶液环境中引发，优选高于水的临界压力（221巴）。 在反应区域内的反应起始温度超过提供超临界条件的水（374℃）的临界温度，这有利于反应的稳定，例如， 超临界水热火焰。 由于反应可以直接在水基钻井液中运行，所以这里提出的方法允许高密度钻井作用，如在常规旋转钻井中。 在需要高温的硬质多晶岩的情况下，所提出的反应的热反应区的一部分可以直接带到岩石表面。

    Sensitization of Drug-Resistant Lung Caners to Protein Kinase Inhibitors
    7.
    发明申请
    Sensitization of Drug-Resistant Lung Caners to Protein Kinase Inhibitors 审中-公开
    耐药肺癌致敏蛋白激酶抑制剂

    公开(公告)号：US20080214521A1

    公开(公告)日：2008-09-04

    申请号：US11997915

    申请日：2006-08-07

    申请人： Martin Schuler

    发明人： Martin Schuler

    IPC分类号： A61K31/553 ,  A61P35/00

    CPC分类号： A61K31/553

    摘要： The present invention relates to a method of treating non-small cell lung cancer with FLT-3 kinase inhibitor such as PKC412. The invention also relates to a pharmaceutical combination of a FLT-3 kinase inhibitor and an activator of permeabilization of the mitochondrial outer membrane, such as an activator of BAK. It also relates to the use of a pharmaceutical combination of an activator of permeabilization of the mitochondrial outer membrane and a FLT-3 kinase inhibitor for the treatment of non-small cell lung cancer and the use of such a pharmaceutical composition for the manufacture of a medicament for the treatment of same.

    摘要翻译： 本发明涉及用FLT-3激酶抑制剂例如PKC412治疗非小细胞肺癌的方法。 本发明还涉及FLT-3激酶抑制剂和线粒体外膜的透化活化剂如BAK的活化剂的药物组合。 它还涉及使用线粒体外膜的透化活化剂和FLT-3激酶抑制剂用于治疗非小细胞肺癌的药物组合，以及这种药物组合物在制备 用于治疗的药物。

    Electrosurgical apparatus
    8.
    发明授权
    Electrosurgical apparatus 失效
    电外科手术器械

    公开(公告)号：US4271837A

    公开(公告)日：1981-06-09

    申请号：US3929

    申请日：1979-01-16

    申请人： Martin Schuler

    发明人： Martin Schuler

    IPC分类号： A61B18/12 ,  A61B17/39

    CPC分类号： A61B18/1206 ,  A61B18/12 ,  A61B2018/0066

    摘要： The present invention relates to an electrosurgical cutting device for the cutting and/or coagulation of tissue with RF current. A cutting electrode and a patient plate are connectable to the terminals of a RF generator. A control system, using a condition change arising at the cutting area during cutting as a controlled value, serves to control the RF current produced by the RF generator as a manipulated variable. The invention is characterized in that, for control of the RF-voltage of the RF generator, the control system responds to d-c voltage that arises at the cutting area during cutting with the RF current.

    摘要翻译： 本发明涉及一种用于用RF电流切割和/或凝结组织的电外科切割装置。 切割电极和患者板可连接到RF发生器的端子。 使用在切割期间在切割区域产生的条件变化作为受控值的控制系统用于控制由RF发生器产生的RF电流作为操作变量。 本发明的特征在于，为了控制RF发生器的RF电压，控制系统响应在用RF电流切割期间在切割区域产生的d-c电压。