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    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
    1.
    发明申请
    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies 有权
    用于特异性检测人源性病原性朊病毒的抗体以及使用这些抗体进行的检测方法

    公开(公告)号：US20070231843A1

    公开(公告)日：2007-10-04

    申请号：US11711020

    申请日：2007-02-27

    申请人： Martin Vey ,  Wiegand Lang ,  Albrecht Groener ,  Anne Bellon

    发明人： Martin Vey ,  Wiegand Lang ,  Albrecht Groener ,  Anne Bellon

    IPC分类号： C07K16/18 ,  C07K14/00 ,  G01N33/53

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N2800/2828

    摘要： This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an epitope characteristic of a human prion protein which is not found in the prion proteins of other species. In some embodiments, the antibodies are not cross-reactive with cow, Syrian Gold hamster, mouse, or rat prions. The application also includes a conformation-dependent immunoassay method for detecting pathogenic prions in a sample containing a prion (PrP) protein. The PrP protein may be present in a first conformation and a second conformation, such as PrPc and PrPSc in which the two conformations have different binding affinity for the antibody used to detect them.

    摘要翻译： 本申请包括用于特异性检测人源性朊病毒的抗体的描述和用于检测病原性朊病毒的方法。 在一些实施方案中，抗体结合人朊蛋白的表位特征，其在其他物种的朊病毒蛋白中未发现。 在一些实施方案中，抗体不与牛，叙利亚金仓鼠，小鼠或大鼠朊病毒交叉反应。 该应用还包括用于检测含有朊病毒（PrP）蛋白质的样品中病原性朊病毒的构象依赖性免疫测定方法。 PrP蛋白可以以第一构象和第二构象存在，例如PrP和PrP Sc Sc，其中两种构象对于用于以下的抗体具有不同的结合亲和力 检测他们

    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
    2.
    发明授权
    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies 有权
    用于特异性检测人源性病原性朊病毒的抗体以及使用这些抗体进行的检测方法

    公开(公告)号：US07202021B2

    公开(公告)日：2007-04-10

    申请号：US10273282

    申请日：2002-10-18

    申请人： Martin Vey ,  Weigand Lang ,  Albrecht Groener ,  Anne Bellon

    发明人： Martin Vey ,  Weigand Lang ,  Albrecht Groener ,  Anne Bellon

    IPC分类号： C12N5/12 ,  C12Q1/70 ,  C07K16/00 ,  C07H21/04 ,  C12N15/63

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N2800/2828

    摘要： This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an epitope characteristic for a human prion protein which is not found in the prion proteins of other species. In some embodiments, the antibodies are not cross-reactive with cow, Syrian Gold hamster, mouse, or rat prions. The application also includes a conformation-dependent immunoassay method for detecting pathogenic prions in a sample containing a prion (PrP) protein. The PrP protein may be present in a first conformation and a second conformation, such as PrPC and PrPSc in which the two conformations have different binding affinity for the antibody used to detect them.

    摘要翻译： 本申请包括用于特异性检测人源性朊病毒的抗体的描述和用于检测病原性朊病毒的方法。 在一些实施方案中，抗体结合在其他物种的朊病毒蛋白中未发现的人朊蛋白的表位特征。 在一些实施方案中，抗体不与牛，叙利亚金仓鼠，小鼠或大鼠朊病毒交叉反应。 该应用还包括用于检测含有朊病毒（PrP）蛋白质的样品中病原性朊病毒的构象依赖性免疫测定方法。 PrP蛋白可以以第一构象和第二构象存在，例如PrP和C pS Sc，其中两种构象对于用于以下的抗体具有不同的结合亲和力 检测他们

    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies
    3.
    发明授权
    Antibodies for specifically detecting pathogenic prions of human origin, and detection methods carried out using these antibodies 有权
    用于特异性检测人源性病原性朊病毒的抗体以及使用这些抗体进行的检测方法

    公开(公告)号：US07863006B2

    公开(公告)日：2011-01-04

    申请号：US11711020

    申请日：2007-02-27

    申请人： Martin Vey ,  Wiegang Lang ,  Albrecht Groener ,  Anne Bellon

    发明人： Martin Vey ,  Wiegang Lang ,  Albrecht Groener ,  Anne Bellon

    IPC分类号： G01N33/53 ,  G01N33/542 ,  G01N1/30 ,  G01N33/48 ,  C12P21/08 ,  C07K16/00

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  G01N2800/2828

    摘要： This application includes description of antibodies for specifically detecting prions of human origin and methods for detecting pathogenic prions. In some embodiments, the antibodies bind to an epitope characteristic of a human prion protein which is not found in the prion proteins of other species. In some embodiments, the antibodies are not cross-reactive with cow, Syrian Gold hamster, mouse, or rat prions. The application also includes a conformation-dependent immunoassay method for detecting pathogenic prions in a sample containing a prion (PrP) protein. The PrP protein may be present in a first conformation and a second conformation, such as PrPc and PrPSc in which the two conformations have different binding affinity for the antibody used to detect them.

    摘要翻译： 本申请包括用于特异性检测人源性朊病毒的抗体的描述和用于检测病原性朊病毒的方法。 在一些实施方案中，抗体结合人朊蛋白的表位特征，其在其他物种的朊病毒蛋白中未发现。 在一些实施方案中，抗体不与牛，叙利亚金仓鼠，小鼠或大鼠朊病毒交叉反应。 该应用还包括用于检测含有朊病毒（PrP）蛋白质的样品中病原性朊病毒的构象依赖性免疫测定方法。 PrP蛋白可以以第一构象和第二构象存在，例如PrPc和PrPSc，其中两种构象对于用于检测它们的抗体具有不同的结合亲和力。

    METHOD FOR THE DETERMINATION OF BOTULINUM NEUROTOXIN BIOLOGICAL ACTIVITY
    6.
    发明申请
    METHOD FOR THE DETERMINATION OF BOTULINUM NEUROTOXIN BIOLOGICAL ACTIVITY 有权
    测定嗜碱性粒细胞生物活性的方法

    公开(公告)号：US20140004541A1

    公开(公告)日：2014-01-02

    申请号：US14004259

    申请日：2012-03-09

    申请人： Klaus Fink ,  Martin Vey

    发明人： Klaus Fink ,  Martin Vey

    IPC分类号： C12Q1/37 ,  C12N9/64

    CPC分类号： C12N9/6472 ,  C12N9/6475 ,  C12Q1/37 ,  C12Y304/22055 ,  C12Y304/22056 ,  C12Y304/22059 ,  C12Y304/2206 ,  C12Y304/22061 ,  C12Y304/22062 ,  C12Y304/22063 ,  G01N33/5014 ,  G01N2333/33 ,  G01N2510/00

    摘要： The present invention relates to means and methods for determining neurotoxin activity. Specifically, it relates to a polypeptide having caspase activity comprising a large subunit and a small subunit wherein the caspase further comprises a neurotoxin cleavage site which upon cleavage activates the caspase activity. Also encompassed are polynucleotides encoding the polypeptides as well as vectors or host cells comprising the polynucleotides. The present invention further relates to a method for determining neurotoxin activity in a sample based on the polypeptide of the invention as well as the use of the polypeptide for determining neurotoxin activity in a sample, in general.

    摘要翻译： 本发明涉及测定神经毒素活性的方法和方法。 具体地说，本发明涉及一种具有半胱天冬酶活性的多肽，其包含大亚基和小亚基，其中半胱天冬酶还包含神经毒素切割位点，其在切割时激活半胱天冬酶活性。 还包括编码多肽的多核苷酸以及包含多核苷酸的载体或宿主细胞。 本发明还涉及基于本发明的多肽测定样品中的神经毒素活性的方法，以及通常用于测定样品中的神经毒素活性的多肽的用途。