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公开(公告)号:US20100232573A1
公开(公告)日:2010-09-16
申请号:US12723023
申请日:2010-03-12
IPC分类号: H05G1/10
CPC分类号: A61B6/04 , A61B6/4441 , A61B6/4464 , A61B6/503 , A61B6/504 , A61B6/542 , A61B6/544 , A61B6/545 , A61B6/547
摘要: A cardiovascular x-ray diagnostic system capable of taking radiographs at different positions by moving at least one of a tabletop on which a subject is placed and a radiographic system equipped with an x-ray tube and an x-ray detector includes: an acquisition unit configured to acquire a radiography position from a position of the tabletop and a position of the radiographic system; a reference position identification unit configured to identify a reference radiography position; and a radiographic unit configured to take radiographs by changing a radiographic parameter based on a current radiography position acquired by the acquisition unit and the reference radiography position.
摘要翻译: 一种心血管x射线诊断系统,其能够通过移动放置被摄体的台面和配备有X射线管和X射线检测器的放射线照相系统中的至少一个来在不同位置拍摄X射线照片,所述X射线诊断系统包括:采集单元 被配置为从所述桌面的位置和所述放射照相系统的位置获取放射照相位置; 参考位置识别单元,被配置为识别参考放射摄影位置; 以及射线照相单元,被配置为通过基于由所述获取单元获取的当前放射摄影位置和所述参考放射摄影位置来改变射线照相参数来拍摄X射线照片。
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公开(公告)号:US07951822B2
公开(公告)日:2011-05-31
申请号:US12413894
申请日:2009-03-30
申请人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Koichi Yamazaki , Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
发明人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Koichi Yamazaki , Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
IPC分类号: A61K31/4166 , A61K31/427 , A61K31/422 , A61K31/45 , A61K31/4525 , C07D405/12 , C07D417/12 , C07D413/12 , C07D407/12
CPC分类号: C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14
摘要: The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译: 目的是提供一种新颖的LXR&bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式(1)表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。
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公开(公告)号:US07376577B1
公开(公告)日:2008-05-20
申请号:US09763942
申请日:1999-08-30
申请人: Shinya Yamadera , Nobuo Iwamura , Naofumi Kutsumi , Tadashi Kinoshita , Teruo Sakamoto , Kenji Mitsuishi , Tsutomu Kaneko , Shin Fujita , Yuichiro Watanabe
发明人: Shinya Yamadera , Nobuo Iwamura , Naofumi Kutsumi , Tadashi Kinoshita , Teruo Sakamoto , Kenji Mitsuishi , Tsutomu Kaneko , Shin Fujita , Yuichiro Watanabe
IPC分类号: G06F17/60
CPC分类号: G06Q10/06 , G06Q10/0631 , G06Q10/06393 , G06Q10/109
摘要: Apparatuses and methods for managing a process that include schedule management, quality, and process management features. Information is stored on an authorized person in charge and a conformity standard for the work to be managed. From this information, a managing method of the work to be managed from among a plurality of managing methods classified in advance is determined. Processes are determined for each management method, and a time limit determined by the authorized person in charge for each managed process. Adherence standards related to the managed processes are included, as well as records made of the process information including the performance quality of the managed process.
摘要翻译: 用于管理流程的设备和方法,包括进度管理,质量和流程管理功能。 信息存储在授权负责人和要管理的工作的合格标准中。 根据该信息,确定从预先分类的多种管理方法中要管理的工作的管理方法。 确定每个管理方法的流程,以及每个被管理流程的授权负责人确定的时间限制。 包括与管理流程相关的遵守标准,以及由过程信息(包括被管理流程的绩效质量)构成的记录。
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公开(公告)号:US08153634B2
公开(公告)日:2012-04-10
申请号:US12474799
申请日:2009-05-29
申请人: Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
发明人: Yuki Yamaguchi , Minoru Koura , Sayaka Kurobuchi , Takayuki Matsuda , Ayumu Okuda , Hisashi Sumida , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号: A61K31/4166 , A61K31/4178 , A61K31/4355 , A61K31/4439 , A61K31/497 , A61K31/501 , A61K31/506 , C07D401/02 , C07D401/06 , C07D405/14 , C07D405/02 , C07D491/048 , C07D233/72 , C07D403/02 , C07D403/06
CPC分类号: C07D233/72 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/04 , C07D405/14 , C07D491/048
摘要: [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.
摘要翻译: [目的]提供一种新型的LXR&bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式(I)表示的甲醇化合物或其盐或其溶剂化物。
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公开(公告)号:US5592846A
公开(公告)日:1997-01-14
申请号:US101860
申请日:1993-08-04
申请人: Yuichiro Watanabe , Kunio Isobe , Ikuo Yarita , Hideyuki Nikaido
发明人: Yuichiro Watanabe , Kunio Isobe , Ikuo Yarita , Hideyuki Nikaido
CPC分类号: B21B37/26 , B21B37/42 , B21B1/26 , B21B13/142 , B21B15/0085 , B21B2027/022
摘要: Herein disclosed is an endless hot rolling method using a hot strip mill substantially composed of a roughing mill and a finishing mill having a roll bender and a roll shifter to continuously roll sequentially joined different rolling materials. The method comprises the steps of: calculating a roll shift range in an axial direction for each rolling material so as to provide a desired crown; determining a rolling sequence so as to obtain a common roll shift range for each pair of neighboring rolling materials; connecting a preceding material at the tail end thereof to the head end of the succeeding material, between the roughing mill and the finishing mill; shifting the rolls during transition from the preceding material to the succeeding material so that the roll position corresponding to the joint of the two materials is within a common roll shift range for the materials; and changing the roll bending load in accordance with the roll shift pattern so as to achieve the desired crown of each material. If the width of a common roll shift range for all the materials is at least 50% of the width of the individual roll shift ranges, rolling can be continuously performed without shifting in an axial direction rolls.
摘要翻译: 本发明公开了一种使用基本由粗轧机组成的热轧带钢轧机和具有轧辊弯曲机和轧辊变速机的精轧机的循环热轧方法,以连续轧制连续不同的轧制材料。 该方法包括以下步骤:计算每个滚动材料的轴向方向的滚动移动范围,以便提供所需的凸度; 确定轧制顺序以获得每对相邻轧制材料的公共轧辊位移范围; 在粗轧机与精轧机之间将其尾端处的先前材料连接到后续材料的头端; 在从先前材料到后续材料的过渡期间移动辊,使得对应于两种材料的接合的辊位置在材料的共同的辊移范围内; 并且根据辊移模式改变辊弯曲载荷,以便实现每种材料的所需冠度。 如果所有材料的普通辊移位范围的宽度是单个辊移范围的宽度的至少50%,则可以在轴向方向辊上不进行移动的情况下连续进行轧制。
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公开(公告)号:US08551985B2
公开(公告)日:2013-10-08
申请号:US12769104
申请日:2010-04-28
申请人: Minoru Koura , Hisashi Sumida , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya , Sumiko Kurobuchi
发明人: Minoru Koura , Hisashi Sumida , Sayaka Kurobuchi , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号: A61K31/496 , A61K31/551 , C07D233/72 , C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D491/048 , C07D491/056
CPC分类号: C07D233/78 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/14 , C07D491/04
摘要: [Object]It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means]A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
摘要翻译: 本发明提供可用作动脉粥样硬化的预防和/或治疗剂的新型LXRbeta激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式(I)表示的甲醇化合物或其盐或其溶剂化物:(其中,V和W各自独立地表示N或C-R7; X和Y各自独立地表示CH 2,C = O ,SO2等; Z表示CH或N;每个R1,R2和R7独立地表示氢原子,C1-8烷基等; R3表示C1-8烷基; R4表示任选取代的C6-10芳基 或任选取代的5至11元杂环基; R 5和R 6表示氢原子等; L表示任选被氧代基等取代的C 1-8烷基链; n表示0〜 2.)
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公开(公告)号:US5218852A
公开(公告)日:1993-06-15
申请号:US830481
申请日:1992-02-04
IPC分类号: B21B13/14
CPC分类号: B21B13/147 , B21B13/142
摘要: A multi-roll cluster rolling apparatus has a pair of work rolls, and a plurality of first intermediate rolls, a plurality of second intermediate rolls and a plurality of backup rolls arranged successively in the mentioned order behind each the work roll. A roll crown presented by unidirectinally tapering one end of a roll is imparted to at least a pair of rolls, e.g., the work rolls, selected from a roll group consisting of the work rolls, first intermediate rolls and the second intermediate rolls. A roll crown approximated by at least one-pitch portion of a waveform is imparted to at least one other pair of rolls, e.g., pairs of the first intermediate rolls. A roll crown approximated by at least two-pitch portion of a waveform is imparted to at least one of the remainder pairs of rolls, e.g., selected pairs of the second intermediate rolls. The rolls of each pair having the same roll crown arranged arranged in opposite axial directions and are axially shiftably mounted on a mill housing.
摘要翻译: 多辊群滚动装置具有一对工作辊,多个第一中间辊,多个第二中间辊和多个支承辊,在工作辊的后方依次排列。 通过将辊的一端单向锥形而呈现的辊冠被赋予至少一对辊,例如选自由工作辊,第一中间辊和第二中间辊组成的辊组的辊。 通过波形的至少一节距部分近似的辊冠被赋予至少一对另一对辊,例如成对的第一中间辊。 通过波形的至少两节距部分近似的辊冠被赋予至少一个剩余的辊对,例如选定的第二中间辊对。 每对的辊具有相同的辊冠,其布置在相反的轴向方向上并且可轴向地安装在磨机壳体上。
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公开(公告)号:US08008306B2
公开(公告)日:2011-08-30
申请号:US12430397
申请日:2009-04-27
申请人: Minoru Koura , Ayumu Okuda , Takayuki Matsuda , Yuki Yamaguchi , Hisashi Sumida , Sayaka Kurobuchi , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
发明人: Minoru Koura , Ayumu Okuda , Takayuki Matsuda , Yuki Yamaguchi , Hisashi Sumida , Sayaka Kurobuchi , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya
IPC分类号: C07D215/12 , C07D215/233 , C07D241/40 , A61K31/4709 , A61K31/498
CPC分类号: C07D401/14 , C07D401/12 , C07D405/14
摘要: To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译: 提供一种新颖的LXR&bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 由以下通式(1)表示的喹啉化合物或其盐或其溶剂化物。
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公开(公告)号:US07919509B2
公开(公告)日:2011-04-05
申请号:US12394548
申请日:2009-02-27
申请人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
发明人: Ayumu Okuda , Takayuki Matsuda , Toru Miura , Hidefumi Ozawa , Ayako Tosaka , Koichi Yamazaki , Yuki Yamaguchi , Sayaka Kurobuchi , Yuichiro Watanabe , Kimiyuki Shibuya
IPC分类号: A61K31/4166 , A61K31/427 , A61K31/45 , A61K31/422 , A61K31/4525 , C07D405/12 , C07D417/12 , C07D413/12 , C07D407/12
CPC分类号: C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/12
摘要: To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.
摘要翻译: 提供一种新颖的LXR&bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式(1)表示的2-氧代色烯衍生物或其盐或其溶剂合物。
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公开(公告)号:US20100280013A1
公开(公告)日:2010-11-04
申请号:US12769104
申请日:2010-04-28
申请人: Minoru Koura , Hisashi Sumida , Sayaka Kurobuchi , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya , Sumiko Kurobuchi
发明人: Minoru Koura , Hisashi Sumida , Sayaka Kurobuchi , Takayuki Matsuda , Yuichiro Watanabe , Takashi Enomoto , Kimiyuki Shibuya , Sumiko Kurobuchi
IPC分类号: A61K31/551 , C07D401/14 , C07D403/06 , C07D407/14 , A61P3/10 , A61P25/28 , A61P3/06 , A61P29/00 , A61K31/496 , A61P7/00 , A61P9/10 , A61P17/00
CPC分类号: C07D233/78 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/04 , C07D405/14 , C07D491/04
摘要: [Object] It is to provide a novel LXRβ agonist useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate: (wherein, each V and W independently show N or C—R7; each X and Y independently show CH2, C═O, SO2, etc; Z shows CH or N; each R1, R2 and R7 independently show a hydrogen atom, C1-8 alkyl group, etc.; R3 shows C1-8 alkyl group; R4 shows an optionally substituted C6-10 aryl group or an optionally substituted 5- to 11-membered heterocyclic group; R5 and R6 show a hydrogen atom, etc.; L shows a C1-8 alkyl chain optionally substituted with an oxo group, etc.; and n shows any integer of 0 to 2.)
摘要翻译: [对象]提供一个新颖的LXR&bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化,如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式(I)表示的甲醇化合物或其盐或其溶剂化物:(其中,V和W各自独立地表示N或C-R7; X和Y各自独立地表示CH 2,C = O ,SO2等; Z表示CH或N;每个R1,R2和R7独立地表示氢原子,C1-8烷基等; R3表示C1-8烷基; R4表示任选取代的C6-10芳基 或任选取代的5至11元杂环基; R 5和R 6表示氢原子等; L表示任选被氧代基等取代的C 1-8烷基链; n表示0〜 2.)
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