公开(公告)号：US20130281465A1

公开(公告)日：2013-10-24

申请号：US13994043

申请日：2011-12-16

申请人： Dai Nozawa ,  Ryo Suzuki ,  Aya Futamura ,  Rie Shimono ,  Masahito Abe ,  Hiroshi Ohta ,  Yuko Araki

发明人： Dai Nozawa ,  Ryo Suzuki ,  Aya Futamura ,  Rie Shimono ,  Masahito Abe ,  Hiroshi Ohta ,  Yuko Araki

IPC分类号： C07D403/12 ,  C07D405/14 ,  A61K31/4439 ,  A61K31/506 ,  A61K31/4192 ,  C07D401/14

CPC分类号： A61K31/4192 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14

摘要： A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which is useful for the treatment or prevention of diseases such sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, pain, gastrointestinal diseases, epilepsy, inflammation, immune-related diseases, endocrine-related diseases, and hypertension, and of which the action relies on an orexin (OX) receptor antagonistic activity.

摘要翻译： 由式（IA）表示的化合物或其药学上可接受的盐，其可用于治疗或预防睡眠障碍，抑郁症，焦虑障碍，恐慌症，精神分裂症，药物依赖，阿尔茨海默氏病，帕金森病，亨廷顿舞蹈病 ，饮食失调，疼痛，胃肠道疾病，癫痫，炎症，免疫相关疾病，内分泌相关疾病和高血压，其作用依赖于食欲素（OX）受体拮抗作用。

公开(公告)号：US20140228377A1

公开(公告)日：2014-08-14

申请号：US14131090

申请日：2012-07-04

申请人： Masahito Abe ,  Aya Futamura ,  Ryo Suzuki ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

发明人： Masahito Abe ,  Aya Futamura ,  Ryo Suzuki ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

IPC分类号： C07D498/04 ,  C07D413/14

CPC分类号： C07D498/04 ,  C07D413/14

摘要： A compound represented by formula (IA) or a pharmaceutically acceptable salt thereof, which acts relying on an orexin (OX) receptor antagonistic activity and is useful for the treatment or prevention of diseases such as sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependence, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, head ache, migraine, pain, gastrointestinal diseases, epilepsy, inflammations, immune-related diseases, endocrine-related diseases and hypertension.

摘要翻译： 由式（IA）表示的化合物或其药学上可接受的盐，其依赖于食欲肽（OX）受体拮抗活性，并且可用于治疗或预防诸如睡眠障碍，抑郁症，焦虑障碍，恐慌症， 精神分裂症，药物依赖，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，饮食失调，头痛，偏头痛，疼痛，胃肠道疾病，癫痫，炎症，免疫相关疾病，内分泌相关疾病和高血压。

公开(公告)号：US20140081025A1

公开(公告)日：2014-03-20

申请号：US14115933

申请日：2012-05-08

申请人： Ryo Suzuki ,  Aya Futamura ,  Masahito Abe ,  Shuhei Kashiwa ,  Nobutaka Hattori ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

发明人： Ryo Suzuki ,  Aya Futamura ,  Masahito Abe ,  Shuhei Kashiwa ,  Nobutaka Hattori ,  Dai Nozawa ,  Hiroshi Ohta ,  Yuko Araki

IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D401/14

CPC分类号： C07D413/14 ,  C07D401/14 ,  C07D403/12 ,  C07D413/12

摘要： The compound represented by formula (IA) or a pharmaceutically acceptable salt thereof is based on orexin (OX) receptor antagonist activity, is useful in the treatment and prevention of illnesses including sleep disorder, depression, anxiety disorder, panic disorder, schizophrenia, drug dependency, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorders, pain, gastrointestinal disease, epilepsy, inflammation, immunological disease, endocrinological related disease, and hypertension.

摘要翻译： 由式（IA）表示的化合物或其药学上可接受的盐是基于食欲肽（OX）受体拮抗剂活性，可用于治疗和预防包括睡眠障碍，抑郁症，焦虑障碍，恐慌症，精神分裂症，药物依赖性 ，阿尔茨海默病，帕金森病，亨廷顿舞蹈病，进食障碍，疼痛，胃肠道疾病，癫痫，炎症，免疫疾病，内分泌相关疾病和高血压。

公开(公告)号：US08623898B2

公开(公告)日：2014-01-07

申请号：US13257258

申请日：2010-03-19

申请人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Shuji Yamamoto ,  Hiroshi Ohta ,  Yoshihisa Shirasaki ,  Kazunari Sakagami ,  Masato Hayashi ,  Tsuyoshi Shibata ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D471/04 ,  C07D405/12 ,  C07D409/12 ,  C07D405/14 ,  A01N43/64 ,  A01N43/50 ,  A61K31/41

CPC分类号： C07D471/04 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsory disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑症（广泛性焦虑障碍，恐慌症，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤和睡眠障碍：

公开(公告)号：US20130184460A1

公开(公告)日：2013-07-18

申请号：US13823574

申请日：2011-09-16

申请人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

发明人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

IPC分类号： C07D405/14 ,  C07D403/12 ,  C07D401/12

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑障碍（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤，疼痛和睡眠障碍：

公开(公告)号：US20130331571A1

公开(公告)日：2013-12-12

申请号：US14000261

申请日：2012-02-21

申请人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

发明人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

IPC分类号： C07D401/04 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

摘要翻译： 本发明涉及式[I]的新化合物或其药学上可接受的盐：本发明的化合物可用于预防或治疗诸如精神分裂症，阿尔茨海默氏病，认知障碍，痴呆，焦虑症（例如， 广泛性焦虑症，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，痉挛，震颤，疼痛，帕金森病，注意缺陷多动障碍，双相 紊乱，进食障碍或睡眠障碍，其基于甘氨酸摄取抑制作用。

公开(公告)号：US20120116095A1

公开(公告)日：2012-05-10

申请号：US13383513

申请日：2010-07-15

申请人： Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Masato Hayashi ,  Yoshihisa Shirasaki ,  Shuji Yamamoto ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

发明人： Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Masato Hayashi ,  Yoshihisa Shirasaki ,  Shuji Yamamoto ,  Youichi Shimazaki ,  Yuko Araki ,  Kumi Abe ,  Xiang-Min Sun

IPC分类号： C07D249/12 ,  C07D233/14

CPC分类号： C07D249/10

摘要： The present invention aims to provide novel compounds represented by formula [I] or pharmaceutically acceptable salts thereof: which are useful for prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, convulsion, tremor, pain, or sleep disorders, based on their inhibitory effect against glycine uptake.

摘要翻译： 本发明旨在提供由式[I]表示的新化合物或其药学上可接受的盐：其可用于预防或治疗诸如精神分裂症，阿尔茨海默病，认知障碍，痴呆，焦虑症（例如广泛性焦虑症， 基于它们对甘氨酸摄取的抑制效果，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，惊厥，震颤，疼痛或睡眠障碍。

公开(公告)号：US08729271B2

公开(公告)日：2014-05-20

申请号：US13823574

申请日：2011-09-16

申请人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

发明人： Minoru Moriya ,  Akito Yasuhara ,  Kazunari Sakagami ,  Hiroshi Ohta ,  Kumi Abe ,  Shuji Yamamoto ,  Yuko Araki ,  Hiroki Urabe ,  Xiang-Min Sun

IPC分类号： A01N43/40 ,  A61K31/44 ,  A01N43/64 ,  A61K31/41 ,  C07D213/00 ,  C07D401/00 ,  C07D419/00

CPC分类号： C07D405/14 ,  C07D233/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： The present invention aims to provide novel compounds of formula [I] or pharmaceutically acceptable salts thereof that are based on a glycine uptake inhibiting action and which are useful in the prevention or treatment of such diseases as schizophrenia, Alzheimer's disease, cognitive dysfunction, dementia, anxiety disorders (generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, posttraumatic stress disorder, specific phobia, acute stress disorder, etc.), depression, drug addiction, spasm, tremor, pain, and sleep disorder:

摘要翻译： 本发明旨在提供基于甘氨酸摄取抑制作用的新颖的式[I]化合物或其药学上可接受的盐，其可用于预防或治疗精神分裂症，阿尔茨海默病，认知功能障碍，痴呆， 焦虑障碍（广泛性焦虑症，惊恐障碍，强迫症，社会焦虑症，创伤后应激障碍，特定恐惧症，急性应激障碍等），抑郁症，药物成瘾，痉挛，震颤，疼痛和睡眠障碍：

公开(公告)号：US20110065667A1

公开(公告)日：2011-03-17

申请号：US12951964

申请日：2010-11-22

申请人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

发明人： Toshio NAKAMURA ,  Makoto Tatsuzuki ,  Dai Nozawa ,  Tomoko Tamita ,  Seiji Masuda ,  Hiroshi Ohta ,  Shuhei Kashiwa ,  Aya Fujino ,  Shigeyuki Chaki ,  Toshiharu Shimazaki

IPC分类号： A61K31/695 ,  C07D231/10 ,  C07D413/12 ,  C07D281/06 ,  C07F7/10 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/553 ,  A61P25/28 ,  A61P25/18 ,  A61P3/10 ,  A61P25/24 ,  A61P25/08 ,  A61P25/00

CPC分类号： C07D231/14 ,  C07D231/40 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D413/04 ,  C07D413/14

摘要： The present invention provides a prophylactic or therapeutic agent for dementia, Alzheimer's disease, attention-deficit hyperactivity disorder, schizophrenia, eating disorders, obesity, diabetes, hyperlipidemia, sleep disorders, narcolepsy, sleep apnea syndrome, circadian rhythm disorder, depression, allergic rhinitis or other diseases.A phenylpyrazole derivative represented by formula (1) or a pharmaceutically acceptable salt thereof: {wherein R1 and R2, which may be the same or different, each represent C1-C6 alkyl or C3-C8 cycloalkyl, or R1 and R2 are attached to each other together with their adjacent nitrogen atom to form a 4- to 7-membered saturated heterocyclic ring (wherein said saturated heterocyclic ring may be substituted with halogen or C1-C6 alkyl), n represents an integer of 0 to 2, T represents a hydrogen atom, halogen or C1-C6 alkyl, and R represents formula (I): or the like}.

公开(公告)号：US08796272B2

公开(公告)日：2014-08-05

申请号：US14000261

申请日：2012-02-21

申请人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

发明人： Minoru Moriya ,  Hiroshi Ohta ,  Shuji Yamamoto ,  Kumi Abe ,  Yuko Araki ,  Xiang-Min Sun ,  Daisuke Wakasugi

IPC分类号： A61K31/50 ,  A61K31/501

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention relates to novel compounds of formula [I] or pharmaceutically acceptable salts thereof: The compounds of the present invention are useful in the prevention or treatment of diseases such as schizophrenia, Alzheimer's disease, cognitive impairment, dementia, anxiety disorders (e.g., generalized anxiety disorder, panic disorder, obsessive-compulsive disorder, social anxiety disorder, post-traumatic stress disorder, specific phobias, acute stress disorder), depression, drug dependence, spasm, tremor, pain, Parkinson's disease, attention deficit hyperactivity disorder, bipolar disorder, eating disorder, or sleep disorders, which is based on the glycine uptake-inhibiting action.

摘要翻译： 本发明涉及式[I]的新化合物或其药学上可接受的盐：本发明的化合物可用于预防或治疗诸如精神分裂症，阿尔茨海默氏病，认知障碍，痴呆，焦虑症（例如， 广泛性焦虑症，恐慌症，强迫症，社交焦虑症，创伤后应激障碍，特异性恐惧症，急性应激障碍），抑郁症，药物依赖性，痉挛，震颤，疼痛，帕金森病，注意缺陷多动障碍，双相 紊乱，进食障碍或睡眠障碍，其基于甘氨酸摄取抑制作用。