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公开(公告)号：US20070161787A1
公开(公告)日：2007-07-12
申请号：US11710434
申请日：2007-02-26
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
IPC分类号： A61K31/7052 , C07H17/00
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
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公开(公告)号：US07977466B2
公开(公告)日：2011-07-12
申请号：US12173614
申请日：2008-07-15
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
IPC分类号： A61K31/7034 , C07H7/04
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
摘要翻译： 本发明提供C-糖苷衍生物及其盐，其中B环通过-X-与A环结合，A环与葡萄糖残基直接结合，可用作Na + - 葡萄糖共转运蛋白抑制剂，尤其用于 胰岛素依赖性糖尿病（1型糖尿病）和胰岛素依赖性糖尿病（2型糖尿病）等糖尿病治疗剂和/或预防剂，以及糖尿病相关疾病如胰岛素抵抗疾病和肥胖症。
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公开(公告)号：US07772407B2
公开(公告)日：2010-08-10
申请号：US11710434
申请日：2007-02-26
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
IPC分类号： A61K31/7034 , A61K31/381 , C07H7/04 , C07D333/34 , C07D495/00
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
摘要翻译： 本发明提供C-糖苷衍生物及其盐，其中B环通过-X-与A环结合，A环与葡萄糖残基直接结合，可用作Na + - 葡萄糖共转运蛋白抑制剂，尤其用于 胰岛素依赖性糖尿病（1型糖尿病）和胰岛素依赖性糖尿病（2型糖尿病）等糖尿病治疗剂和/或预防剂，以及糖尿病相关疾病如胰岛素抵抗疾病和肥胖症。
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公开(公告)号：US07202350B2
公开(公告)日：2007-04-10
申请号：US10541615
申请日：2004-03-12
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
摘要翻译： 本发明提供C-糖苷衍生物及其盐，其中B环通过-X-与A环键合，并且A环直接键合到葡萄糖残基，并且其可用作Na + 葡萄糖共转运蛋白抑制剂，特别是用于糖尿病的治疗和/或预防剂，例如胰岛素依赖性糖尿病（1型糖尿病）和不依赖胰岛素的糖尿病（2型糖尿病），以及糖尿病相关疾病如胰岛素抵抗 疾病和肥胖。
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公开(公告)号：US20090069252A1
公开(公告)日：2009-03-12
申请号：US12173614
申请日：2008-07-15
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
IPC分类号： A61K31/7042 , C07H7/06
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
摘要翻译： 本发明提供C-糖苷衍生物及其盐，其中B环通过-X-与A环结合，A环与葡萄糖残基直接结合，可用作Na + - 葡萄糖共转运蛋白抑制剂，尤其用于 胰岛素依赖性糖尿病（1型糖尿病）和胰岛素依赖性糖尿病（2型糖尿病）等糖尿病治疗剂和/或预防剂，以及糖尿病相关疾病如胰岛素抵抗疾病和肥胖症。
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公开(公告)号：US20060122126A1
公开(公告)日：2006-06-08
申请号：US10541615
申请日：2004-03-12
申请人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
发明人： Masakazu Imamura , Takeshi Murakami , Ryota Shiraki , Kazuhiro Ikegai , Takashi Sugane , Fumiyoshi Iwasaki , Eiji Kurosaki , Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi
IPC分类号： C07H23/00 , A61K31/7052
CPC分类号： C07D495/04 , A61K31/351 , A61K31/381 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , C07D405/10 , C07D407/10 , C07D409/10 , C07D413/10 , C07D417/10
摘要： The present invention provides C-glycoside derivatives and salts thereof, wherein B ring is bonded to A ring via —X— and A ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes related diseases such as an insulin-resistant diseases and obesity.
摘要翻译： 本发明提供C-糖苷衍生物及其盐，其中B环通过-X-与A环键合，并且A环直接键合到葡萄糖残基，并且其可用作Na + 葡萄糖共转运蛋白抑制剂，特别是用于糖尿病的治疗和/或预防剂，例如胰岛素依赖性糖尿病（1型糖尿病）和不依赖胰岛素的糖尿病（2型糖尿病），以及糖尿病相关疾病如胰岛素抵抗 疾病和肥胖。
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公开(公告)号：US07169761B2
公开(公告)日：2007-01-30
申请号：US10491618
申请日：2003-08-04
申请人： Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi , Masakazu Imamura , Takeshi Murakami , Kazuhiro Ikegai , Takayuki Suzuki , Eiji Kurosaki
发明人： Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi , Masakazu Imamura , Takeshi Murakami , Kazuhiro Ikegai , Takayuki Suzuki , Eiji Kurosaki
CPC分类号： C07D309/12 , C07D309/10
摘要： The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes-related diseases such as insulin-resistant diseases and obesity.
摘要翻译： 本发明提供了薁衍生物及其盐，其中薁环直接或通过可被卤素原子取代的低级亚烷基与苯环键接，苯环与葡萄糖残基直接键合， 可用作Na + + - 葡萄糖共转运蛋白抑制剂，特别是用于糖尿病治疗和/或预防剂如胰岛素依赖性糖尿病（1型糖尿病）和胰岛素不依赖性糖尿病（2型糖尿病） ，以及糖尿病相关疾病如胰岛素抵抗疾病和肥胖症。
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公开(公告)号：US20050124555A1
公开(公告)日：2005-06-09
申请号：US10491618
申请日：2003-08-04
申请人： Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi , Masakazu Imamura , Takeshi Murakami , Kazuhiro Ikegai , Takayuki Suzuki , Eiji Kurosaki
发明人： Hiroshi Tomiyama , Atsushi Noda , Kayoko Kitta , Yoshinori Kobayashi , Masakazu Imamura , Takeshi Murakami , Kazuhiro Ikegai , Takayuki Suzuki , Eiji Kurosaki
IPC分类号： A61P3/04 , A61P3/10 , A61P43/00 , C07D309/10 , C07D309/12 , C07H15/24 , A61K31/704
CPC分类号： C07D309/12 , C07D309/10
摘要： The present invention provides an azulene derivative and a salt thereof, wherein an azulene ring is bonded to a benzene ring directly or via a lower alkylene which may be substituted with a halogen atom and the benzene ring is directly bonded to the glucose residue, and it is usable as a Na+-glucose cotransporter inhibitor, especially for a therapeutic and/or preventive agent for diabetes such as insulin-dependent diabetes (type 1 diabetes) and insulin-independent diabetes (type 2 diabetes), as well as diabetes-related diseases such as insulin-resistant diseases and obesity.
摘要翻译： 本发明提供了薁衍生物及其盐，其中薁环直接或通过可被卤素原子取代的低级亚烷基与苯环键接，苯环与葡萄糖残基直接键合， 可用作Na + + - 葡萄糖共转运蛋白抑制剂，特别是用于糖尿病治疗和/或预防剂如胰岛素依赖性糖尿病（1型糖尿病）和胰岛素不依赖性糖尿病（2型糖尿病） ，以及糖尿病相关疾病如胰岛素抵抗疾病和肥胖症。
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