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179 条记录 (耗时 0.047 秒)

    C-glycosides and preparation of thereof as antidiabetic agents
    10.
    发明授权
    C-glycosides and preparation of thereof as antidiabetic agents 有权
    C-糖苷及其作为抗糖尿病药的制剂

    公开(公告)号：US06627611B2

    公开(公告)日：2003-09-30

    申请号：US09766600

    申请日：2001-01-23

    申请人： Hiroshi Tomiyama ,  Yoshinori Kobayashi ,  Atsushi Noda ,  Akira Tomiyama ,  Tsuyoshi Tomiyama

    发明人： Hiroshi Tomiyama ,  Yoshinori Kobayashi ,  Atsushi Noda ,  Akira Tomiyama ,  Tsuyoshi Tomiyama

    IPC分类号： A61K3170

    CPC分类号： C07D405/10 ,  C07D309/10 ,  C07D407/10 ,  C07D407/14 ,  C07D409/10

    摘要： C-glycoside derivatives are disclosed, which are represented by the following formula (I) and its pharmaceutical acceptable salt, and which are useful for the treatment and/or prevention of diabetes and hypoglycemia. wherein: with the provisos that R1 is H, OH, lower alkyl, O-lower alkyl or R2 is H, —COO-lower alkyl, R5 is —CH2OH, —CH2OCO2-lower alkyl, —CH2OSO3H, —COOH or —COONa; wherein: A is (with the provisos that X is oxygen atom, nitrogen atom or sulfur atom R3 is lower alkyl when m=0, and is lower alkyl, —OH or —O-lower alkyl when m=1, . . . means saturated or unsaturated carbon bond; m is 0 or 1; n is 0, 1 or 2; above mentioned-lower alkyl means C1-C5.) or a pharmaceutical acceptable salt.

    摘要翻译： 公开了由下式（I）表示的C-糖苷衍生物及其药学上可接受的盐，其可用于治疗和/或预防糖尿病和低血糖。其中：条件是R 1是H，OH， 低级烷基，O-低级烷基或R 2为H，-COO-低级烷基，R 5为-CH 2 OH，-CH 2 OCO 2 - 低级烷基，-CH 2 OSO 3 H，-COOH或-COONa;其中：A为（条件是X为氧原子 当m = 0时，氮原子或硫原子R 3为低级烷基，m = 1时为低级烷基，-OH或-O-低级烷基，表示饱和或不饱和碳键; m为0或1; n为 0,1或2;上述低级烷基手段C1-C5）或药学上可接受的盐。