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    Preparation for transdermal drug administration
    1.
    发明授权
    Preparation for transdermal drug administration 失效
    透皮给药制剂

    公开(公告)号：US5368860A

    公开(公告)日：1994-11-29

    申请号：US798149

    申请日：1991-11-26

    申请人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    发明人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

    IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/245 ,  A61K31/46 ,  A61K31/47 ,  A61K45/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  A61F13/02

    CPC分类号： A61K9/7061 ,  A61K31/165

    摘要： A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.

    摘要翻译： 用于经皮给药的制剂包括柔性背衬层和含有40-65重量％比例的局部麻醉剂的压敏粘合剂层。 由于粘合剂层中未溶解的局部麻醉剂（Ac）与溶解的局部麻醉剂（As）Ac / As的比例确定为0.1-1.8，所以制剂 对于本发明的透皮给药，自身粘合性优异，从皮肤上除去时没有粘合剂。 此外，在施用于皮肤之后立即从压敏粘合剂层中爆发出的未溶解药物的释放允许快速出现麻醉效果，这使得本发明的制剂能够广泛的临床应用。

    Anti-cancer activity potentiator
    2.
    发明授权
    Anti-cancer activity potentiator 失效
    抗癌活性增强剂

    公开(公告)号：US5182267A

    公开(公告)日：1993-01-26

    申请号：US626302

    申请日：1990-12-12

    申请人： Osamu Ogawa ,  Ikuo Kishi ,  Yoshiyuki Tahara ,  Masanori Sugita

    发明人： Osamu Ogawa ,  Ikuo Kishi ,  Yoshiyuki Tahara ,  Masanori Sugita

    IPC分类号： A61K9/107 ,  A61K31/135

    CPC分类号： A61K9/1075 ,  A61K31/135

    摘要： A pharmaceutical oil-in-water type microemulsion having an action of potentiating the activities of anti-cancer agents, said micro-emulsion comprisesfine particles of a vegetable oil or a triglyceride of a medium-chain fatty acid having 8 to 12 carbon atoms containing 0.1 to 10% (w/v) of N-solanesyl-N,N'-bis(3,4-dimethoxybenzyl)ethylenediamine malate of formula (I) below, ##STR1## an aqueous medium, and 0.05 to 25% (w/v) of a physiologically acceptable phospholipid for dispersing said fine particles in said aqueous medium.

    摘要翻译： 具有增强抗癌剂活性的作用的药用油包水型微乳液，所述微乳液包含具有8至12个碳原子的中链脂肪酸的植物油或甘油三酸酯的细颗粒，其含有 0.1至10％（w / v）下式（I）的N-茄酰基-N，N'-双（3,4-二甲氧基苄基）乙二胺苹果酸盐，水性介质，和 用于将所述细颗粒分散在所述水性介质中的生理学上可接受的磷脂的0.05至25％（w / v）。