公开(公告)号：US5368860A

公开(公告)日：1994-11-29

申请号：US798149

申请日：1991-11-26

申请人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

发明人： Masaki Sunami ,  Koji Maruyama ,  Mitsuhiko Hori ,  Shoichi Tokuda ,  Kenichiro Saito ,  Ikuo Kishi

IPC分类号： A61K9/70 ,  A61K31/165 ,  A61K31/245 ,  A61K31/46 ,  A61K31/47 ,  A61K45/00 ,  A61P23/02 ,  A61P25/02 ,  A61P25/04 ,  A61F13/02

CPC分类号： A61K9/7061 ,  A61K31/165

摘要： A preparation for transdermal drug administration comprising a flexible backing layer and a pressure-sensitive adhesive layer containing a local anesthetic in a proportion of 40-65 weight %. Since the ratio of the amount of the undissolved local anesthetic (Ac) to that of the dissolved local anesthetic (As), Ac/As, in the pressure-sensitive adhesive layer is determined to be in the range of 0.1-1.8, the preparation for transdermal drug administration of the present invention is superior in self-adhesiveness and leaves no adhesive material upon removal from the skin. In addition, burst-like release of the undissolved drug from the pressure-sensitive adhesive layer immediately after application to the skin permits rapid appearance of the anesthetic effect, which enables wide clinical application of the preparations of the present invention.

摘要翻译： 用于经皮给药的制剂包括柔性背衬层和含有40-65重量％比例的局部麻醉剂的压敏粘合剂层。 由于粘合剂层中未溶解的局部麻醉剂（Ac）与溶解的局部麻醉剂（As）Ac / As的比例确定为0.1-1.8，所以制剂 对于本发明的透皮给药，自身粘合性优异，从皮肤上除去时没有粘合剂。 此外，在施用于皮肤之后立即从压敏粘合剂层中爆发出的未溶解药物的释放允许快速出现麻醉效果，这使得本发明的制剂能够广泛的临床应用。

公开(公告)号：US4720542A

公开(公告)日：1988-01-19

申请号：US822961

申请日：1986-01-28

申请人： Takashi Omura ,  Yasuo Tezuka ,  Masaki Sunami

发明人： Takashi Omura ,  Yasuo Tezuka ,  Masaki Sunami

IPC分类号： C09B62/503 ,  C09B62/44 ,  D06P3/66 ,  C09B50/00 ,  C09B62/095 ,  C09B62/535 ,  D06P1/38

CPC分类号： C09B62/4407

摘要： A formazan reactive blue dye represented by a free acid of the formula, ##STR1## wherein X.sub.1 and X.sub.2 are each a hydrogen atom, a methyl, methoxy or sulfonic acid group, m and l are each an integer of 0 or 1 and n is an integer of 0 to 2, provided that the sum of m, n and l is 2 or 3. This dye is usable for dyeing cellulose fibers in a brilliant blue color with good fastness, particularly, against chlorine, light and perspiration-light, as well as good white dischargeability.

摘要翻译： 由下式游离酸代表的甲an反应性蓝色染料，其中X 1和X 2各自为氢原子，甲基，甲氧基或磺酸基，m和l各自为0 或1，n为0〜2的整数，条件是m，n和l之和为2或3。该染料可用于以良好的牢度，特别是氯，光的亮蓝色染色纤维素纤维 和汗水，以及良好的白色放电性。

公开(公告)号：US4663440A

公开(公告)日：1987-05-05

申请号：US266642

申请日：1981-05-26

申请人： Takashi Omura ,  Masaki Sunami ,  Yasuo Tezuka

发明人： Takashi Omura ,  Masaki Sunami ,  Yasuo Tezuka

IPC分类号： C09B62/513 ,  C09B43/16 ,  C09B62/44 ,  C09B62/09 ,  C09B62/533 ,  D06P1/382 ,  D06P1/384

CPC分类号： C09B62/4415

摘要： A brown reactive dye represented by a free acid of the formula, ##STR1## wherein R is a hydrogen atom or a C.sub.1 to C.sub.4 alkyl group, X is --SO.sub.2 CH.sub.2 CH.sub.2 Cl, --SO.sub.2 CH.dbd.CH.sub.2, --SO.sub.2 CH.sub.2 CH.sub.2 OSO.sub.3 H or --SO.sub.2 CH.sub.2 CH.sub.2 OPO.sub.3 H.sub.2, rings A, B and C are each a benzene or naphthalene ring which may have other substituent, m is 0 to 3 and n is 0 to 1.This dye is suitable for dyeing cellulose fibers brown to afford dyeings superior in fastnesses, acid stability, build-up property and level dyeing property.

摘要翻译： 由下式游离酸代表的褐色活性染料，其中R是氢原子或C1-C4烷基，X是-SO2CH2CH2Cl，-SO2CH = CH2，-SO2CH2CH2OSO3H或-SO2CH2CH2OPO3H2 环A，B和C各自为可以具有其它取代基的苯或萘环，m为0至3，n为0至1.该染料适用于将纤维素纤维染色为棕色，以提供优异的耐晒牢度，酸稳定性 ，建筑物和水平染色性能。

公开(公告)号：US4937326A

公开(公告)日：1990-06-26

申请号：US714361

申请日：1985-03-22

申请人： Yutaka Kayane ,  Masaki Sunami ,  Katsumasa Otake ,  Yasuo Tezuka

发明人： Yutaka Kayane ,  Masaki Sunami ,  Katsumasa Otake ,  Yasuo Tezuka

IPC分类号： C09B62/44

CPC分类号： C09B62/4413

摘要： A novel reactive monoazo dye, which can give to cellulose fiber materials a deep orange to scarlet color superior in build-up property and chlorine fastness, represented by a free acid of the formula, ##STR1## wherein D is a phenyl group substituted with 1 to 3 substitutes selected from methyl, ethyl, methoxy, ethoxy, halogen, acetylamino, propionylamino, benzoylamino, succinylamino, maleinylamino, nitro, suflonic acid and carboxyl groups; R.sub.1 is a hydrogen atom, or a methyl or ethyl group; R.sub.2 is an alkyl group having 1 to 4 carbon atoms which is unsubstituted or substituted with a hydroxy, cyano, alkoxy, halogen, carboxy, alkoxycarbonyl or sulfonic acid group; Z is a hydrogen atom or a sulfonic acid group; A is a phenylene residue which is unsubstituted or substituted with 1 or 2 substituents selected from methyl, ethyl, methoxy, ethoxy, chlorine, bromine and sulfonic acid groups; or a naphthylene residue which is unsubstituted or substituted with one sulfonic acid group; and X is --SO.sub.2 CH.dbd.CH.sub.2 or --SO.sub.2 CH.sub.2 CH.sub.2 Y in which Y is a group which is splittable by alkalis.

摘要翻译： 一种新型的反应性单偶氮染料，其可以赋予纤维素纤维材料深层橙色至具有优异的聚集性能和耐氯牢度的猩红色，由下式的游离酸代表：其中D是被1个 至3个选自甲基，乙基，甲氧基，乙氧基，卤素，乙酰氨基，丙酰氨基，苯甲酰基氨基，琥珀酰氨基，马来酰氨基，硝基，磺酰基和羧基的取代基。 R1是氢原子，或甲基或乙基; R2是未取代的或被羟基，氰基，烷氧基，卤素，羧基，烷氧基羰基或磺酸基团取代的具有1至4个碳原子的烷基; Z是氢原子或磺酸基; A是未取代的或被1或2个选自甲基，乙基，甲氧基，乙氧基，氯，溴和磺酸基的取代基取代的亚苯基; 或未被取代或被一个磺酸基团取代的亚萘基残基; X为-SO 2 CH = CH 2或-SO 2 CH 2 CH 2 Y，其中Y为可被碱分解的基团。

公开(公告)号：US20080305169A1

公开(公告)日：2008-12-11

申请号：US11753247

申请日：2007-05-24

申请人： Kazuki Miki ,  Fuyuki Arimoto ,  Masaki Sunami

发明人： Kazuki Miki ,  Fuyuki Arimoto ,  Masaki Sunami

IPC分类号： A61K9/36 ,  A61K31/538 ,  A61K31/5415 ,  A61K31/55 ,  A61K31/498 ,  A61K31/553 ,  A61K9/28

CPC分类号： C07D209/08 ,  A61K9/2018 ,  A61K9/2077 ,  C07D215/08 ,  C07D223/16 ,  C07D241/42 ,  C07D243/12 ,  C07D265/36 ,  C07D265/38 ,  C07D267/14 ,  C07D279/16 ,  C07D413/06 ,  C07D498/04

摘要： [Problems] The present invention provides pharmaceutical composition which is effective for the prophylaxis or treatment of pathology showing involvement of uric acid (hyperuricemia, gouty tophus, acute gout arthritis, chronic gout arthritis, gouty kidney, urolithiasis, renal function disorder, coronary arterial disease, ischemic heart disease and the like) and the like, and is superior in the time-course stability and dissolution property (disintegration property). [Solving Means] The pharmaceutical composition of the present invention is a pharmaceutical composition comprising a nitrogen-containing fused ring compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable additives, wherein the nitrogen-containing fused ring compound or a pharmaceutically acceptable salt thereof is not in contact with a basic additive: wherein each symbol is as described in the specification.

摘要翻译： [问题]本发明提供了有效预防或治疗尿酸（高尿酸血症，痛风性痛，急性痛风性关节炎，慢性痛风性关节炎，痛风肾，尿路结石，肾功能障碍，冠状动脉疾病 ，缺血性心脏病等）等，并且时间稳定性和溶解性（崩解性）优异。 [解决方案]本发明的药物组合物是包含由下式[1]表示的含氮稠环化合物或其药学上可接受的盐和一种或多种药学上可接受的添加剂的药物组合物， 含有稠环化合物或其药学上可接受的盐不与碱性添加剂接触：其中每个符号如说明书中所述。

公开(公告)号：US20060153913A1

公开(公告)日：2006-07-13

申请号：US11256201

申请日：2005-10-24

申请人： Shogo Yamane ,  Hirofumi Yamane ,  Masaki Sunami

发明人： Shogo Yamane ,  Hirofumi Yamane ,  Masaki Sunami

IPC分类号： A61K31/47 ,  A61K31/454 ,  A61K9/20

CPC分类号： A61K9/2027 ,  A61K9/0056 ,  A61K9/143 ,  A61K9/146 ,  A61K9/1635 ,  A61K9/1652 ,  A61K9/2009 ,  A61K9/2054 ,  A61K31/225 ,  A61K31/454 ,  A61K31/47

摘要： The present invention relates to a solid formulation with improved solubility and maintained stability including a chemical substance poorly soluble in water as a pharmaceutically active ingredient formulated in an improved manner. More specifically, the present invention relates to a solid formulation having improved water-solubility which comprises a chemical substance poorly soluble in water as a pharmaceutically active ingredient, a water-soluble polymer substance and an inorganic porous substance, characterized in that (1) the chemical substance poorly soluble in water forms a solid dispersion together with the water-soluble polymer substance, (2) the water-soluble polymer substance forming the solid dispersion is in the form of fine pieces, and (3) the water-soluble polymer substance is in the form of fine pieces is maintained to be adsorbed on and/or adhered to the surface of the inorganic porous substance. The solid formulation can be produced by stirring and mixing a solution obtained by dissolving a chemical substance poorly soluble in water as a pharmaceutically active ingredient and a water-soluble polymer substance in an organic solvent with an inorganic porous substance and then granulating and drying the mixture.

摘要翻译： 本发明涉及具有改善的溶解性和保持稳定性的固体制剂，包括以改进的方式配制的药物活性成分不溶于水的化学物质。 更具体地说，本发明涉及具有改善的水溶性的固体制剂，其包含难溶于水作为药物活性成分的化学物质，水溶性聚合物物质和无机多孔物质，其特征在于（1） 难溶于水的化学物质与水溶性聚合物物质一起形成固体分散体，（2）形成固体分散体的水溶性聚合物物质为细片，（3）水溶性聚合物物质 以细片的形式被保持吸附在无机多孔物质表面上和/或附着于无机多孔物质的表面上。 固体制剂可以通过将通过将难溶于水的化学物质作为药物活性成分和水溶性聚合物物质溶解在有机溶剂中而获得的溶液与无机多孔物质混合，然后将混合物制粒和干燥来制备 。

公开(公告)号：US4341699A

公开(公告)日：1982-07-27

申请号：US166194

申请日：1980-07-07

申请人： Yasuo Tezuka ,  Masaki Sunami ,  Takashi Omura ,  Yutaka Kayane

发明人： Yasuo Tezuka ,  Masaki Sunami ,  Takashi Omura ,  Yutaka Kayane

IPC分类号： C09B62/44 ,  C07C107/08 ,  C09B62/085 ,  C09B62/51

CPC分类号： C09B62/4413

摘要： A dye represented by a free acid of the formula, ##STR1## wherein A is ##STR2## in which Z is --CH.sub.2 CH.sub.2 OSO.sub.3 H or --CH.dbd.CH.sub.2. This dye is usable for dyeing cellulose fibers in brilliant red color with good fastness, particularly, too chlorine, light and perspiration-light and possesses level dyeing properties.

摘要翻译： 由下式游离酸代表的染料，其中A是Z，其中Z是-CH 2 CH 2 OSO 3 H或-CH = CH 2。 该染料可用于染色具有良好牢度的亮红色纤维素纤维，特别是氯，轻和排汗光，并具有良好的染色性能。

公开(公告)号：US5830497A

公开(公告)日：1998-11-03

申请号：US655007

申请日：1996-05-29

申请人： Akihito Yamanaka ,  Takashi Kinoshita ,  Masaki Sunami

发明人： Akihito Yamanaka ,  Takashi Kinoshita ,  Masaki Sunami

IPC分类号： A61K9/70 ,  A61L15/44 ,  A61L15/58 ,  A61F13/02 ,  A61K9/14

CPC分类号： A61K9/7053 ,  A61K9/7023 ,  A61K9/7061 ,  A61L15/44 ,  A61L15/58 ,  A61L2300/204 ,  A61L2300/21 ,  A61L2300/40 ,  Y10S514/818 ,  Y10S514/821 ,  Y10S514/906 ,  Y10S514/929

摘要： Medicated plasters composed of a flexible support and a pressure-sensitive adhesive layer laminated thereon, in which said pressure-sensitive adhesive layer has an exposed surface with pH of 7 or higher and contains one of the following three components: i) a basic physiologically active agent and an acidic substance, ii) a salt of a basic physiologically active agent and a basic substance, and iii) a basic physiologically active agent and a salt of a basic physiologically active agent.

摘要翻译： 由柔性支持体和层压在其上的压敏粘合剂层组成的药膏，其中所述压敏粘合剂层具有pH为7或更高的暴露表面，并且包含以下三种组分之一：i）基本的生理活性 药剂和酸性物质，ii）碱性生理活性剂和碱性物质的盐，和iii）碱性生理活性剂和碱性生理活性剂的盐。

公开(公告)号：US4412948A

公开(公告)日：1983-11-01

申请号：US164243

申请日：1980-06-30

申请人： Takashi Omura ,  Yasuo Tezuka ,  Masaki Sunami

发明人： Takashi Omura ,  Yasuo Tezuka ,  Masaki Sunami

IPC分类号： C09B62/513 ,  C09B62/44 ,  D06P3/66 ,  C09B31/047

CPC分类号： C09B62/4415

摘要： A bisazo reactive dye represented by a free acid of the formula, ##STR1## wherein X.sub.1 and X.sub.2 are each a hydrogen atom, a methyl or methoxy group, a chlorine atom, or a carboxylic acid or sulfonic acid group, Y is a hydrogen atom, a methyl or sulfonic acid group, Z is --CH.sub.2 CH.sub.2 OSO.sub.3 H, --CH.sub.2 CH.sub.2 OPO.sub.3 H.sub.2, --CH.sub.2 CH.sub.2 Cl or --CH.dbd.CH.sub.2, and Z.sub.1, Z.sub.2 and Z.sub.3 are each a hydrogen or chlorine atom, a methyl, methoxy, sulfonic acid or carboxylic acid group. This dye is usable for dyeing cellulose fibers in a deep blue color with good fastnesses, particularly, chlorine, light and perspiration-light fastnesses, a high acid stability, good white dischargeability as well as level dyeing properties.

摘要翻译： 由下式的游离酸代表的双唑反应性染料，其中X 1和X 2各自为氢原子，甲基或甲氧基，氯原子或羧酸或磺酸基团， Y是氢原子，甲基或磺酸基，Z是-CH2CH2OSO3H，-CH2CH2OPO3H2，-CH2CH2Cl或-CH = CH2，Z1，Z2和Z3各自是氢或氯原子，甲基，甲氧基，磺酸 或羧酸基团。 该染料可用于染色具有良好坚牢度的深蓝色的纤维素纤维，特别是氯，轻，耐汗牢度，高酸稳定性，良好的白色放电性以及均匀的染色性能。

公开(公告)号：US4384868A

公开(公告)日：1983-05-24

申请号：US356345

申请日：1982-03-09

申请人： Masaki Sunami ,  Takemi Tokieda ,  Sadaharu Abeta

发明人： Masaki Sunami ,  Takemi Tokieda ,  Sadaharu Abeta

IPC分类号： C09B67/22 ,  C09B67/24 ,  D06P1/38 ,  C09B62/00

CPC分类号： C09B67/0051 ,  C09B67/0072 ,  Y10S534/01 ,  Y10S8/918

摘要： A reactive dye composition containing a dye mixture comprising 60 to 97 wt. % of C.I. Reactive Orange 16 and 40 to 3 wt. % of C.I. Reactive Orange 7, and 5 to 100 parts by weight per 100 parts by weight of said dye mixture of a naphthalenesulfonic acid/formaldehyde condensate having a sulfonation degree of 100 to 200%, which is very readily soluble in water and an aqueous alkaline solution and useful for dyeing cellulose fibers with a high color yield.

摘要翻译： 含有染料混合物的活性染料组合物包含60-97重量％ ％的C.I. 活性橙16和40至3重量％ ％的C.I. 活性橙7和5至100重量份，相对于100重量份所述磺酸/甲醛缩合物的染料混合物，其磺化度为100至200％，其非常容易溶于水和碱性水溶液， 可用于以高产率染色纤维素纤维。